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| 1 | Mesenteric ischemia:Pathogenesis and challengingdiagnostic and therapeutic modalities显示文摘Mesenteric ischemia(MI) is an uncommon medical condition with high mortality rates. ΜΙ includes inadequate blood supply, inflammatory injury and eventually necrosis of the bowel wall. The disease can be divided into acute and chronic MI(CMI), with the first being subdivided into four categories. Therefore, acute MI(AMI) can occur as a result of arterial embolism, arterial thrombosis, mesenteric venous thrombosis and nonocclusive causes. Bowel damage is in proportion to the mesenteric blood flow decrease and may vary from minimum lesions, due to reversible ischemia, to transmural injury, with subsequent necrosis and perforation. CMI is associated to diffuse atherosclerotic disease in more than 95% of cases, with all major mesenteric arteries presenting stenosis or occlusion. Because of a lack of specific signs or due to its sometime quiet presentation, this condition is frequently diagnosed only at an advanced stage. Computed tomography(CT) imaging and CT angiography contribute to differential diagnosis and management of AMI. Angiography is also the criterion standard for CMI, with mesenteric duplex ultrasonography and magnetic resonance angiography also being of great importance. Therapeutic approach of MI includes both medical and surgical treatment. Surgical procedures include restoration of the blood flow with arteriotomy, endarterectomy or anterograde bypass, while resection of necrotic bowel is always implemented. The aim of this review was to evaluate the results of surgical treatment for MI and to present the recent literature in order to provide an update on the current concepts of surgical management of the disease. Mesh words selected include MI, diagnostic approach and therapeutic management. | Aikaterini Mastoraki Sotiria Mastoraki Evgenia Tziava Stavroula Touloumi Nikolaos Krinos Nikolaos Danias Andreas Lazaris Nikolaos Arkadopoulos | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 23 |
| 2 | Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies显示文摘Lung cancer is currently the leading cause of cancer death in Western nations.Non-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological type.Despite the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful treatment.Recent studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these drugs.This article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior. | Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António MF Araújo | 2011 | World Journal of Clinical Oncology2011，2，11： | 16 |
| 3 | Steroid hyperglycemia: Prevalence, early detection and therapeutic recommendations: A narrative review显示文摘Steroids are drugs that have been used extensively in a variety of conditions. Although widely prescribed for their anti-inflammatory and immunosuppressive properties, glucocorticoids have several side effects, being hyperglycemia one of the most common and representative. In the present review, we discuss the main epidemiologic characteristics associated with steroid use, with emphasis on the identification of high risk populations. Additionally we present the pathophysiology of corticosteroid induced hyperglycemia as well as the pharmacokinetics and pharmacodynamics associated with steroid use. We propose a treatment strategy based on previous reports and the understanding of the mechanism of action of both, the different types of glucocorticoids and the treatment options, in both the ambulatory and the hospital setting. Finally, we present some of the recent scientific advances as well as some options for future use of glucocorticoids. | Héctor Eloy Tamez-Pérez Dania Lizet Quintanilla-Flores René Rodríguez-Gutiérrez José Gerardo González-González Alejandra Lorena Tamez-Pena | 2015 | World Journal of Diabetes2015，6，8： | 12 |
| 4 | Health-related quality of life outcomes after cholecystectomy显示文摘Gallbladder diseases are very common in developed countries. Complicated gallstone disease represents the most frequent of biliary disorders for which surgery is regularly advocated. As regards, cholecystectomy represents a common abdominal surgical intervention; it can be performed as either an elective intervention or emergency surgery, in the case of gangrene, perforation, peritonitis or sepsis. Nowadays, the laparoscopic approach is preferred over open laparotomy. Globally, numerous cholecystectomies are performed daily; however, little evidence exists regarding assessment of post-surgical quality of life (QOL) following these interventions. To assess post-cholecystectomy QOL, in fact, documentation of high quality care has been subject to extended discussions, and the use of patientreported outcome satisfaction for quality improvement has been advocated for several years. However, there has been little research published regarding QOL out-comes following cholecystectomy; in addition, much of the current literature lacks systematic data on patientcentered outcomes. Then, although several tools have been used to measure QOL after cholecystectomy, diffi culty remains in selecting meaningful parameters in order to obtain reproducible data to reflect postoperative QOL. The aim of this study was to review the impact of surgery for gallbladder diseases on QOL. This review includes Medline searches of current literature on QOL following cholecystectomy. Most studies demonstrated that symptomatic patients profi ted more from surgery than patients receiving an elective intervention. Thus, the gain in QOL depends on the general conditions before surgery, and patients without symptoms profi t less or may even have a reduction in QOL. | Amedeo Carraro Dania El Mazloum Florian Bihl | 2011 | World Journal of Gastroenterology2011，17，45： | 5 |
| 5 | Human papillomavirus and gastrointestinal cancer: A review显示文摘Human papillomavirus(HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common,and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic,but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri,penis,vulva,vagina,anus and oropharynx,including the base of the tongue and the tonsils. However,studies of the aetiological role of HPV in colorectal and esophageal malignancies have conflicting results. The aim of this review was to organize recent evidence and issues about the association between HPV infection and gastrointestinal tumours with a focus on esophageal,colorectal and anal cancers. The ultimate goal was to highlight possible implications for prognosis and prevention. | Dania Bucchi Fabrizio Stracci Nicola Buonora Giuseppe Masanotti | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 6 | Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis显示文摘Metastatic disease from cutaneous melanoma can af-fect all organs of the body, and varies in its biological behavior and clinical presentation. We present the case of a 58-year-old man who arrived at our clinic with acute abdominal pain, which, after investigation, was diagnosed as acute cholecystitis. The patient under-went laparotomy and cholecystectomy. Two years ago, he underwent surgical removal of a primary cutaneous melanoma on his right upper back. Pathological exami-nation revealed the presence of malignant melanoma with a metastatic lesion of the gallbladder. | Spiridon Vernadakis Georgios Rallis Nikolaos Danias Costas Serafi midis Evangelos Christodoulou Michail Troullinakis Nikolaos Legakis Georgios Peros | 2009 | World Journal of Gastroenterology2009，15，27： | 3 |
| 7 | Fetal DNA detection in maternal plasma throughout gestation显示文摘 | Silvia Galbiati Maddalena Smid Dania Gambini Augusto Ferrari Gabriella Restagno Elsa Viora Mario Campogrande Simona Bastonero Marco Pagliano Stefano Calza Maurizio Ferrari Laura Cremonesi | 2005 | Human Genetics (-)2005，，2： | 2 |
| 8 | Combined assessment of myocardial perfusion and left ventricular function with exercise technetium-99m sestamibi gated single-photon emission computed tomography can differentiate between ischemic and nonischemic dilated cardiomyopathy显示文摘 | Danias PG Ahlberg AW Clark BA | 1998 | Am J Cardiol1998，82，： | 1 |
| 9 | Comparison of aortic elasticity determined by cardiovascular magnetic resonance imagingin obese versus lean adults显示文摘 | Danias PG Tritos NA Stuber M | 2003 | Am J Cardiol2003，91，2： | 1 |
| 10 | Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model显示文摘 | Mittag TW Danias J Pohorenec G | 2000 | Invest Ophthalmol Vis Sci2000，41，： | 1 |
| 11 | Method for the noninvasive measurement of intraocular pressure in mice 显示文摘 | Danias J Kontiola AI Filippopoulos T | 2003 | Invest Ophthalmol Vis Sic2003，44，： | 1 |
| 12 | Combined assess- ment of myocardial perfusion and left ventricular function with ex- ercise technetium-99m sestamibi gated single-photon emission com- puted tomography can differentiate between ischemic and noniseh- emic dilated cardiomyopathy显示文摘 | Danias PG Ahlberg AW Clark BA 3rd | 1998 | Am J Cardiol1998，82，10： | 1 |
| 13 | Analysis of sediment transport modeling using computational fluid dynamics(CFD) for aquaculture raceways显示文摘 | Dania L Huggins Raul H Piedrahita Tom Rumsey | 2004 | Aquacultural Engineering2004，31，34： | 1 |
| 14 | Reproductive performance after selective tubal catheterization显示文摘 | Dania Al-Jaroudi Milton J. Herba Togas Tulandi | 2005 | The Journal of Minimally Invasive Gynecology2005，，2： | 1 |
| 15 | Coronary magnetic resonance angiography for the detection of coronary stenoses显示文摘 | Kim WY Danias PG Stuber M | 2001 | N Engl J Med2001，315，26： | 1 |
| 16 | Electrocardiogram-gated single-photon emission computed tomography versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction:a meta-analysis显示文摘 | Ioannidis JP Trikalinos TA Danias PG | 2002 | J Am Coll Cardiol2002，39，12： | 1 |
| 17 | Fatal cardiacarrest due to an unusual fibroma of the pulmonary valve显示文摘 | Kiaffas MG Danias PG Kaklamanis L | 2009 | Pediatr Cardiol2009，30，： | 1 |
| 18 | Coronary Magnetic Resonance Angiography for the Deteetion of Coronary Stenoses显示文摘 | Kim WY Danias PG Stuber M | 2001 | N Engl J Med2001，345，26： | 1 |
| 19 | Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia显示文摘 | Dania A. Shah Raouf A. Khalil | 2015 | Biochemical Pharmacology2015，，： | 1 |
| 20 | Likelihood of spontaneous conversion of atrial fibrillation to sinus rhythm显示文摘 | Danias PG Callfield TA Weigner NJ | 1998 | JACC1998，31，3： | 1 |
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