5篇
您的检索式：作者名="Daniel Leduc"
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| 1 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 2 | Antidiabetic Activity of Nigella sativa . Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes*显示文摘 | Ali Benhaddou-Andaloussi Louis C. Martineau Danielle Spoor Tri Vuong Charles Leduc Erik Joly Andrew Burt Bouchra Meddah Abdellatif Settaf John T. Arnason Marc Prentki Pierre S. Haddad | 2008 | Pharmaceutical Biology (-)2008，，1： | 1 |
| 3 | Preserving the authenticity of Contingent Digital Objects:The InterPARES Project显示文摘 | LeDuc Daniel | | 0，，06： | 1 |
| 4 | Antidiabetic Activity of Nigella sativa . Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes*显示文摘 | Ali Benhaddou-Andaloussi Louis C. Martineau Danielle Spoor Tri Vuong Charles Leduc Erik Joly Andrew Burt Bouchra Meddah Abdellatif Settaf John T. Arnason Marc Prentki Pierre S. Haddad | 2008 | Pharmaceutical Biology (-)2008，，1： | 1 |
| 5 | Unveiling the mysteries of the Kermadec Trench显示文摘On October 29^(th),2022,scientists from China and New Zealand left Auckland on board the R/V Tansuoyihao to use,for the first time,the full-ocean-depth human-occupied vehicle(HOV)Fendouzhe to systematically explore the Kermadec Trench.The first 1-month-long leg of the voyage was successfully completed on November 25th,2022.The HOV Fendouzhe conducted 16 dives between 5747 and 10010 m in depth,with five dives exceeding 9000 m and two dives to the Scholl Deep,the deepest point of the Kermadec Trench.On November 4th,a first dive to the Scholl Deep was conducted by a scientist(Dr.Kareen Schnabel)from New Zealand National Institute of Water&Atmospheric Research and two pilots(Ms.Yuqing Deng and Mr.Xin Yuan)from the Institute of Deep-sea Science and Engineering,who spent 6 h exploring the Scholl Deep and the adjacent western slope of the trench.This was the first time a female scientist reached the deepest point of this trench.Following a short return to Auckland for re-supply and staff changeover,the second leg of the voyage will be completed before the end of December with another 15 dives planned. | Xiaotong Peng Weijia Zhang Kareen Schnabel Daniel Leduc Hengchao Xu Hanyu Zhang Haibin Zhang Ashley Rowden | 2023 | The Innovation2023，4，1： | 0 |
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