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| 1 | XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks显示文摘 | Julie K Horton Mary Watson Donna F Stefanick Daniel T Shaughnessy Jack A Taylor Samuel H Wilson | 2008 | Cell Research2008，18，1： | 17 |
| 2 | Pyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia显示文摘AIM: To test the hypothesis that fluid resuscitation with Ringer's solution enriched with pyruvate(PR), a physiological antioxidant and energy substrate, affords protection of myocardial metabolism and electrophysiological performance superior to lactated Ringer's(LR) during hypovolemia and hindlimb ischemia-reperfusion.METHODS: Male domestic goats(25-30 kg) were exsanguinated to a mean arterial pressure of 48 ± 1 mm Hg. Right hindlimb ischemia was imposed for 90 min by applying a tourniquet and femoral crossclamp. LR or PR, infused iv, delivered 0.05 mmol/kg per minute L-lactate or pyruvate, respectively, from 30 min hindlimb ischemia until 30 min post-ischemia. Time controls(TC) underwent neither hemorrhage, hindlimb ischemia nor resuscitation. Goats were sacrificed and left ventricular myocardium biopsied at 90 min fluid resuscitation(n = 6 per group) or 3.5 h later(n = 9 LR, 10 PR, 8 TC).RESULTS: Myocardial 8-isoprostane content, phosphocreatine phosphorylation potential, creatine kinase activity, and heart rate-adjusted QT interval(QTc) vari- ability were evaluated at 90 min resuscitation and 3.5 h post-resuscitation. PR sharply lowered pro-arrhythmic QTc variability vs LR(P < 0.05); this effect persisted 3.5 h post-resuscitation. PR lowered myocardial 8-isoprostane content, a product of oxidative stress, by 39 and 37% during and 3.5 h after resuscitation, respectively, vs LR. Creatine kinase activity fell 42% post-LR vs TC(P < 0.05), but was stable post-PR(P < 0.02 vs post-LR). PR doubled phosphocreatine phosphorylation potential, a measure of ATP free energy state, vs TC and LR(P < 0.05); this energetic enhancement persisted 3.5 h post-resuscitation.CONCLUSION: By augmenting myocardial energy state and protecting creatine kinase activity, pyruvateenriched resuscitation stabilized cardiac electrical function during central hypovolemia and hindlimb ischemiareperfusion. | Hunaid A Gurji Daniel W White Besim Hoxha Jie Sun Albert H Olivencia-Yurvati Robert T Mallet | 2013 | World Journal of Critical Care Medicine2013，2，4： | 3 |
| 3 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 4 | Measurement of scenic beauty :the law of comparative judgment and scenic beauty estimation proce-dures 显示文摘 | Hulliv H B Buhyoff G J Daniel T C | 1984 | Forest Science1984，30，4： | 1 |
| 5 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 6 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 7 | Path- ogenicity and immunogenicity of a listeria monoeytogenes strain that requires D-alanine for growth 显示文摘 | ROBERT J T ARCHIE H G DANIEL A P | 1998 | Infection and Immunity1998，66，8： | 1 |
| 8 | Relating extractable soil phosphorus to phosphorus losses in runoff显示文摘 | Pote D H Daniel T C Sharpley A N etal | 1996 | Soil Sci- ence Society of America Journal1996，60，： | 1 |
| 9 | Virilixzing ovarian tumor of low malignant potential associated with antecedent tomaxifen use for breast cancer显示文摘 | Daniel VS Irene H Joachim T | 1998 | Gynecol Oncol1998，68，3： | 1 |
| 10 | Nutritional evaluation (per)of soybean protein and combinations of food proteins 显示文摘 | FRED H S ELMER E P DANIEL T | 1980 | Journal of Food Science1980，45，2： | 1 |
| 11 | Managing pine straw harvests to minimize soil and water losses 显示文摘 | Pote D H Daniel T C | 2008 | Journal of Soil and Water Conservation2008，93，1： | 1 |
| 12 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 13 | Molecular mechanisms of biocatalytic desulfurization of fossil fuels显示文摘 | Kevin A G Olga S P Gregry T M Lei X Daniel J M Charles H S | 1996 | Nature Biotechnology1996，14，12： | 1 |
| 14 | Relating Extractable Soil Phosphorus Losses in Runoff 显示文摘 | Pote D H Daniel T C Sharpley A N | 1996 | Soil Science Society of American Journal1996，60，： | 1 |
| 15 | Spatial pattern and species richness of boreonemoral forest understory and its determinants-A comparison of differently managed forests 显示文摘 | Moora M Daniell T Kalle H | 2007 | Forest Ecol Manage2007，250，： | 1 |
| 16 | The Ecological Footprint: A Non-Monetary Metric of Human Consumption Applied to North America显示文摘 | Senbel M Mc Daniel T Dowlatabadi H | 2003 | Grobal Environmental Change2003，13，： | 1 |
| 17 | Relating extractable soil phosphorus to phosphorus losses in runoff显示文摘 | Pote D H Daniel T C | 1996 | Soil Science Society of A merican Journal1996，60，： | 1 |
| 18 | Relationship between phosphorus levels in three Ultisols and phosphorus concentrations in runoff显示文摘 | Pote D H Daniel T C Nichols D J | 1999 | J Environ Qual1999，28，： | 1 |
| 19 | The shared landscape: what does aesthetics have to do with ecology? 显示文摘 | Gobster P H Nassauer J I Daniel T C | 2007 | Landscape Ecology2007，22，： | 1 |
| 20 | 显示文摘 | Elisabeth H V Daniel J T | 2006 | Organic Letters2006，8，10： | 1 |
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