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您的检索式：作者名="Daniel del Castillo"
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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Inspiratory Muscle Training in Patients With COPD显示文摘 | Hildegard Sánchez Riera Teodoro Montemayor Rubio Francisco Ortega Ruiz Pilar Cejudo Ramos Daniel Del Castillo Otero Teresa Elias Hernandez Jose Castillo Gomez | 2001 | Chest2001，，3： | 1 |
| 3 | Gastric volvulus after sleeve gastrectomy for morbid obesity显示文摘 | Daniel Del Castillo Déjardin Fàtima Sabench Pereferrer Mercè Hernàndez Gonzàlez Santiago Blanco Blasco Arantxa Cabrera Vilanova | 2012 | Surgery2012，，： | 1 |
| 4 | Pregnancy-related psychopathology:A comparison between pre-COVID-19 and COVID-19–related social restriction periods显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic impacted in a still undefined way pregnant women’s mental health.There are reports of mood and affect changes in the general population and the suggestion that similar changes occur also in the pregnant population.The greater vulnerability of women during the COVID-19 restriction period may translate into a greater risk for mental disorders in the gestational period.We hypothesised that pregnant women in the prepandemic period would have less psychopathology and more psychological support than pregnant women during the pandemic restriction period.AIM To compare pregnant women for anxiety,prenatal depression,psychopathology,and social support before and after the awareness of the pandemic.METHODSWe administered to women willing to participate in their 2nd-3rd trimesters of pregnancy theEdinburgh Postnatal Depression Scale(EPDS),the State-Trait Anxiety Inventory Form Y(STAI-Y),and the Symptom CheckList-90-Revised(SCL-90R);we further collected sociodemographicvariables and explored women’s social support.The comparison was cross-sectional.The firstsample was termed nonCOVID-19 because data were gathered before the COVID-19 outbreak(January 2020-February 2020)was declared,and the second sample termed COVID-19 becauseparticipants were already subjected to the COVID-19-related restrictive measures(January 2021-February 2021).Since normal distribution was not met(Shapiro-Wilk test applied),we appliednonparametric Mann-Whitney’s U-test to compare psychometric tests.Ethical standards were met.RESULTSThe nonCOVID-19 group reported higher support from partners only,while the COVID-19 groupreported multiple support(χ^(2)=9.7181;P=0.021);the nonCOVID-19 group scored higher than theCOVID-19 group only on state anxiety among psychometric scales[STAI-Y1,nonCOVID-19median=39(95%CI:39.19-51.10)vs COVID-19 median=32(95%CI:30.83-38.90);Mann-Whitney’sU=117.5,P=0.00596].Other measures did not differ meaningfully between the two groups.Scoreson the EPDS,the state and trait subscales of the STAI-Y,and most SCL-90R subscales intercorrelatedwith one another.The anxiety component of the EPDS,EPDS-3A,correlated poorlywith other measures,while it was the Global Symptom Index of the SCL-90-R that correlated moststrongly with most measures.Our results are at odds with most literature and do not confirmincreased depression and anxiety rates in pregnant women during the pandemic.CONCLUSIONThe ability of pregnant women to deal with novel generalised threats involves mobilization ofinner resources.Increasing sources of social support may have produced anxiolysis in the COVID-19 sample. | Daniela Chieffo Carla Avallone Annamaria Serio Georgios Demetrios Kotzalidis Marta Balocchi Ilaria De Luca Daniele Hirsch Angela Gonsalez del Castillo Pierluigi Lanzotti Giuseppe Marano Lucio Rinaldi Antonio Lanzone Eugenio Mercuri Marianna Mazza Gabriele Sani | 2022 | World Journal of Clinical Cases2022，10，19： | 0 |
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