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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells显示文摘人的 pluripotent 干细胞(hPSC ) 导出 endothelial 系细胞组成有希望的来源因为在这个竞技场的治疗学的 revascularization,而是进步被临床上可伸缩的区别协议和在移植之上与宿主发行量集成的一个功能的容器网络的低效的形成的缺乏妨碍了。在绿的地方,使用一根人的胚胎的干细胞记者房间线荧光灯蛋白质表示被 endothelial 驾驶房间特定的 VE-cadherin (VEC ) 倡导者,我们为 > 屏蔽了;60 bioactive 将支持 endothelial 区别,并且发现 BMP4 和 GSK-3β 的那个政府的小分子;在有 VEGF 的一个早阶段和处理的禁止者 -- 在一个以后的阶段表明小径的槽口的 A 和抑制在六天以内导致了 hPSCs 的有效区别到 endothelial 系。这条顺序的途径产生了 >到 endothelial 房间(EC ) 的 hPSCs 的50%变换,明确地 VEC + CD31 + CD34 + CD14 − KDR 在 endothelial 系房间之中展出了更高的 angiogenic 和 clonogenic 增长潜力的高 endothelial 祖先( EP )。药品的抑制或基因槽口发信号击倒,在有 VEGF 的联合 -- 一个处理,经由 KDR + mesodermal 先锋和对成熟 EC 的 EP 的变换的封锁导致了 EP 的有效形成。当移植了进 immunocompromised 老鼠时,产生 EP 成功地与吻合在 vivo 形成了功能的毛状的容器到主人容器。在我们的协议表明电路的这 VEGF-A-Notch 的操作由 12- 导致导出 hPSC 的 EP 的快速的大规模生产到 20 褶层对当前的方法,它可以与与成熟 EC 相比形成能力的优异容器为再生 vascularization 用作一张吸引人的房间人口。 | Makoto Sahara Emil M Hansson Oliver Wemet Kathy O Lui Daniela Spater Kenneth R Chien | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Residual C-peptide secretion and endothelial function in patients with type 2 diabetes显示文摘 | Daniela M Emilia R Angela MA | 2003 | Clinical Science2003，105，1： | 1 |
| 4 | Residual C-peptide secretion and endothelial function in patients with type2 diabetes显示文摘 | Daniela M Emilia R Angela Marie A | 2003 | Clinical Science2003，105，： | 1 |
| 5 | PEComas: The past, the present and the future 显示文摘 | Guido M Maurizio P Daniela R | 2008 | Virchows Arch2008，452，： | 1 |
| 6 | Overconfidence in absolute and relative performance: the regression hypothesis and bayesian updating显示文摘 | Daniela G Hogarth R M | 2009 | Journal of Economic Psychology2009，30，5： | 1 |
| 7 | Microcystin-producing blooms a serious global public health issue显示文摘 | DANIELA R DE F ULISSES M | 2004 | Eeotoxicology and Environmental Safety2004，，59： | 1 |
| 8 | Utilization of noninvasive ventilation in acute care hospitals,a regional survey显示文摘 | Vinay M Daniela P Robert R | 2006 | Chest2006，129，： | 1 |
| 9 | Functional role of inflame matory cytokines and anti-inflammatory molecules in seizures and epilep togenesis显示文摘 | Annamaria V Daniela M Cristinal R | 2002 | Epilepsia2002，43，5： | 1 |
| 10 | Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity显示文摘 | Clóvis R N Aurea D S Chuck S F Fernando C R | | J Biol Chem0，275，27： | 1 |
| 11 | Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample 显示文摘 | Maria M Simona M Daniela D R | 2001 | Biol Proced Online2001，3，1： | 1 |
| 12 | Protective immune response against methicillin resistant Staphylococcus aureus in a murine model using a DNA vaccine approach显示文摘 | Jose P S Daniela M R Jaim S O | 2003 | Vaccine2003，21，2021： | 1 |
| 13 | Taspine : Bioactivity-guided Isolation and Molecular Ligand-target Insight of a Potent Acetylcholinesterase Inhibitor from Magnolia x Soulangiana 显示文摘 | Judith M R Daniela S Elisabeth B | 2006 | J Nat Prod2006，69，9： | 1 |
| 14 | Evaluation of mutagenic and antimutagenic activities of α- bisabolol in the SalmoneUa/micresome assay显示文摘 | Gomes-Carneiro M R Dias Daniela M M De-Oliveira A C A X | 2005 | Muta Res Gen Toxlcol Environ Mutagen2005，585，12： | 1 |
| 15 | TNF - a eliminationwith high cut - off haemofilters : a feasible clinical modality for sep-tic patients? 显示文摘 | STANISLAO M DANIELA K JENS R | 2003 | Nephrol Dial Transplant2003，18，7： | 1 |
| 16 | Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample 显示文摘 | Maria M Simona M Daniela D R | 2001 | Btol Proced Online2001，3，1： | 1 |
| 17 | Protective immune response against methicillin resistant Staphylococcus aureusin a murine model using a DNA vaccine approach显示文摘 | Jose P S Daniela M R Jaim S O | 2003 | Vaccine2003，21，2021： | 1 |
| 18 | Microcystinproducing blooms-a serious global public health issue 显示文摘 | Daniela R F Ulisses M A Sonia M E | 2004 | Ecotoxicol Environ Saf2004，59，： | 1 |
| 19 | Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis显示文摘 | Annamaria V Daniela M Cristinal R | 2002 | Epilepsia2002，43，5： | 1 |
| 20 | Residual C - peptide secre- tion and endothelial function in patients with type 2 diabetes 显示文摘 | Daniela M Emilia R Angela MA | 2003 | Clin- ical Science2003，105，1： | 1 |
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