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| 1 | Variations of mesoscale eddy SST fronts based on an automatic detection method in the northern South China Sea显示文摘SST fronts at the mesoscale eddy edge(ME fronts)were investigated from 2007–2017 in the northern South China Sea(NSCS)based on an automatic method using satellite sea level anomaly(SLA)and SST data.The relative probabilities between the number of anticyclonic/cyclonic ME fronts(AEF/CEF)and the number of anticyclones/cyclones reached 20%.The northeastern and southwestern parts of these anticyclones had more fronts than the northwestern and southeastern parts,although CEFs were nearly equally distributed in all directions.The number of ME fronts had remarkable seasonal variations,while the eddy kinetic energy(EKE)showed no seasonal variations.The total EKE at the ME fronts was three times of that within the MEs,and it was much stronger in AEFs than in CEFs.The interannual variability in the number of ME fronts and EKE had no significant correlation with the El Ni?o-Southern Oscillation(ENSO)index.Possible mechanisms of ME fronts were discussed,but the contributions of mesoscale eddies to SST fronts need to be quantified in future studies. | Chunhua Qiu Juan Ouyang Jiancheng Yu Huabin Mao Yongfeng Qi Jiaxue Wu Danyi Su | 2020 | Acta Oceanologica Sinica2020，39，11： | 1 |
| 2 | Interannual variability in the sea surface cooling induced by tropical cyclones in the South China Sea显示文摘Sea surface cooling induced by tropical cyclones(TCs)is an important component of air-sea interactions.Using coordinate transformation and composite analysis methods,we examined the interannual variability in TCinduced sea surface cooling(TCSSC)in the South China Sea(SCS).The frequency of surface cooling cases was over 86%and that of surface warming cases was less than 14%.The magnitude of TCSSC was defined as the absolute value of TCSSC.The maximum magnitude of TCSSC occurred on the right side of the TC track,and the mean magnitude of TCSSC decreased by 0.04℃/a from 2006 to 2018.The interannual variability in TCSSC was highly correlated with the TC translation speed and pre-TC mixed layer depth.Notably,TCSSC got enhanced in El Nino years of 2007,2010,and 2015.The El Nino types were suggested to determine the occurring periods of strong TCSSC via controlling the positions of SCS anticyclones,which brought pre-TC shallow mixed layer and caused strong TCSSC via vertical mixing process during El Nino events.To quantify how the anticyclone influences TCSSC,we need to use mixed layer heat balances model in the next study. | Juan Ouyang Chunhua Qiu Zhenhui Yi Dongxiao Wang Danyi Su Hong Liang Zihao Yang | 2021 | Acta Oceanologica Sinica2021，40，11： | 0 |
| 3 | Genomic evolution during locoregional recurrence in colorectal cancer determined by whole-exome sequencing: a retrospective observational study显示文摘Objective:The genomic landscapes of metastatic colorectal cancer(mCRC)have been extensively studied;however,the genetic mechanisms underlying the locoregional recurrence(LR)of CRC remain unclear.The objective of our study was to investigate genomic evolution during LR in CRC using high-throughput sequencing.Methods:Twenty-three CRC patients with matched primary and LR tissues were recruited from Nanfang Hospital and Zhejiang Cancer Hospital between January 2011 and December 2018.The last date of follow-up was March 2020.Tissue samples were analyzed by whole-exome sequencing and the genomic profiles were depicted by single nucleotide variation,mutational signature,copy number variation,clonal architecture,and other features.The evolutionary process was speculated with comparison of the genetic variations between primary and LR lesions.The disseminating clusters from primary to LR lesions were identified by variant allele frequency dynamics.Furthermore,the early-recurrent biomarker was explored by comparing the indel signature between early-and late-recurrent patients.The study was approved by the Institutional Review Board of Nanfang Hospital of Southern Medical University(approval No.2020010)on September 11,2020.Results:The results highlighted distinct origins of LR between patients with high microsatellite instability and microsatellite stability.LR lesions evolved independently in patients with high microsatellite instability,while LR lesions were highly clonally related to the primary lesions in patients with microsatellite stability.Late-acquired variations in LR lesions encompassed a wide range of driver genes involved in histone methylation,DNA replication,T cell activation,PDCD1 gain,and LMNA loss.Furthermore,clonal analysis of the disseminating cells identified a dominant polyclonal seeding pattern during LR.The indel signature ID4 was associated with significantly shorter disease-free survival in patients with relapsed CRC according to a public dataset.Conclusion:These findings pose a challenge for the development of new approaches targeting the interactions of multiple clones in the establishment of LR and in terms of optimizing the clinical management of susceptible patients. | Xiaoliang Lan Xiaoxiao Wu Chao Zhang Genxia Wei Bingbing Li Weihao Qiu Danyi Li Huanwen Wu Yanqing Ding Jie Yuan Zaixian Tai Zuoquan Yang Zhiyong Liang Dan Su Li Liang | 2022 | Journal of Bio-X Research2022，5，4： | 0 |
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