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| 1 | HuoguⅠformula prevents steroid-induced osteonecrosis in rats by down-regulating PPARγ expression and activating Wnt/LRP5/β-catenin signaling显示文摘OBJECTIVE: To investigate the effects of HuoguⅠformula on regulation of lipid metabolism in steroid-induced osteonecrosis of the femoral head(SONFH) rats and verify our hypothesis that HuoguⅠ formula regulates lipid metabolism by down-regulating peroxisome proliferator-activated receptor gamma(PPARγ) expression and activating Wnt signaling pathways.METHODS: Eighty-five rats were divided into four groups: control, model, Huogu 15 g/kg and Huogu30 g/kg. Six weeks later, animals were anaesthetized, femora were dissected for histopathological examination of the osteonecrotic changes and repair processes, micro computed tomography(Micro-CT)-based micro-angiography was performed to assess vascularization. Serum lipid levels were detected by haematological examination. The expressions of PPARγ, Wnt3a, low density lipoprotein receptor-related protein 5(LRP5) and β-catenin were evaluated by immunohistochemistry,Western blot and quantitative real-time polymerase chain reaction analyses.RESULTS: The incidence of osteonecrosis, ratio of empty lacuna, adipose tissue area and adipocyte perimeter in the bone marrow were dramatically lower in the Huogu Ⅰ formula treatment groups.Bymicro-CTquantification,HuoguⅠformulatreatment dose-dependently increased vessel volume,vessel surface, percentage of vessel volume and vessel thickness of the femoral heads of SONFH rats. Levels of serum lipid in Huogu 15 g/kg and Huogu 30 g/kg groups reduced significantly.HuoguⅠformula treatment could suppress the expression of PPARγ and increase the expressions of Wnt3a, LRP5 and β-catenin at both protein and mRNA levels.CONCLUSION: The results of our present study highlight the lipid-lowering potential of Huogu Ⅰformula, and provide further evidence of the involvement of the PPARγ inhibition and Wnt/LRP5/β-catenin signaling activation in the effects of HuoguⅠformula. | Yini Jiang Daobing Liu Xiangying Kong Ying Xu Weiheng Chen Na Lin | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 18 |
| 2 | Artificial Hair-Like Sensors Inspired from Nature: A Review显示文摘 | Zhiwu Han Linpeng Liu Kejun Wang Honglie Song Daobing Chen Ze Wang Shichao Niu Junqiu Zhang Luquan Ren | 2018 | Journal of Bionic Engineering2018，15，3： | 6 |
| 3 | Crack-based and Hair-like Sensors Inspired from Arthropods:A Review显示文摘Over a long period of time,arthropods evolve to have two excellent mechanical sensilla of slit sensilla and trichobothria sensilla,which construct a perfect perception system.The former mainly perceives the change of the in-the-plane force while the latter perceives that of the out-of-plane force.In recent years,these two sensilla have attracted researchers as the models for developing artificial mechanical sensors.This review mainly includes the biomechanics and biomimetic manufacturing techniques as well as their future application value.In order to better understand the advantages of biological strategies,this review describes the morphology,mechanical analysis,and information recognition of slit sensilla and trichobothria sensilla.Then this review highlights the recent development of Crack-based Sensors(CBSs)and Hair-like Sensors(HLSs)based on the analysis of biological mechanism.The manufacturing method and substrate of crack in CBS and those of hair rods in HLS are discussed respectively.Finally,the practical applications and potential value of two sensilla,such as flexible wearable electronic devices,robot sensing system,autopilot sensing and wind tunnel speed detection,are briefly discussed. | Changchao Zhang Junqiu Zhang Daobing Chen Xiancun Meng Linpeng Liu Kejun Wang Zhibin Jiao Tao Sun Dakai Wang Shichao Niu Zhiwu Han Luquan Ren | 2020 | Journal of Bionic Engineering2020，17，5： | 2 |
| 4 | Fine Structure of Scorpion Pectines for Odor Capture显示文摘 | Zhiwu Han Daobing Chen Ka Zhang Honglie Song Kejun Wang Shichao Niu Junqiu Zhang Luquan Ren | 2017 | Journal of Bionic Engineering2017，14，4： | 1 |
| 5 | Large Curvature Folding Strategies of Butterfly Proboscis显示文摘Due to its real-time control,high folding ratio,and structure self-locking,flexible large curvature self-folding devices have broad application prospects,such as foldable human implants,flexible electronics,and flexible robots.Driven by this background,flexible large curvature folding butterfly(Polyura eudamippus)proboscises were studied in this work.The folding ratio of the proboscises was about 15.The curvature of coiled proboscises ranged from about 150 m_1 to 880 m The external and internal structures of the proboscises were studied by different methods.Three main strategies for large-curvature folding of proboscises were identified:a gradual decrease in thickness,a lower elastic modulus,and(most importantly)large numbers of regular corrugated cracks arranged on the surface.These corrugated cracks can effectively accommodate the coiled strain and provide space for the large curvature folding of proboscises.Finally,a 4D printed coiled sample with corrugated cracks was fabricated to mimic the proboscises stretching process.Large-curvature folding strategies,based on these proboscises,provide insights for the biomimetic design of artificial highly folded components. | Daobing Chen Honglie Song Qingping Liu Jie Gan Yang Liu Keyu Che' Chong Wang Shifeng Wen Yan Zhou Chunze Yan Junqiu Zhang Yusheng Shi Zhiwu Han | 2020 | Journal of Bionic Engineering2020，17，6： | 1 |
| 6 | Micro/nano-scale Characterization and Fatigue Fracture Resistance of Mechanoreceptor with Crack-shaped Slit Arrays in Scorpion显示文摘The nocturnal scorpion Heterometrus petersii uses Basitarsal Compound Slit Sensilla (BCSS) as mechanoreceptor to detect mechanical signal (e.g. substrate vibration, cyclic loads caused by walking) without fatigue failure such as initiation of fatigue crack and further propagation of crack-shaped slit. The outstanding perceptive function has been discovered for over half a century. However, it is not yet clear about the microstructure, material composition and micromechanical property which are all important factors that determine the fatigue fracture resistance of the BCSS. Here, the microscopic characteristics of the BCSS were thoroughly studied. The results dicate that anti-fatigue resilin and stiff chitinous cuticle form multilayered composite as the main body of the BCSS. Meanwhile, the pre-existing slit as mechanosensory structure is covered by cuticular membrane which has different mechanical property with the epicuticle. Theoretical analysis shows that the structure-composition-property synergistic relations of composites confer on the BCSS with extreme fatigue fracture tolerance. | Kejun Wang Junqiu Zhang Yuqiang Fang Daobing Chen Linpeng Liu Zhiwu Han Luquan Ren | 2019 | Journal of Bionic Engineering2019，16，3： | 1 |
| 7 | A Numerical Study on the Propagation Mechanisms of Hydraulic Fractures in Fracture-Cavity Carbonate Reservoirs显示文摘Field data suggests that carbonate reservoirs contain abundant natural fractures and cavities.The propagation mechanisms of hydraulic fractures in fracture-cavity reservoirs are different from conventional reservoirs on account of the stress concentration surrounding cavities.In this paper,we develop a fully coupled numerical model using the extended finite element method(XFEM)to investigate the behaviors and propagation mechanisms of hydraulic fractures in fracture-cavity reservoirs.Simulation results show that a higher lateral stress coefficient can enhance the influence of the natural cavity,causing a more curved fracture path.However,lower confining stress or smaller in-situ stress difference can reduce this influence,and thus contributes to the penetration of the hydraulic fracture towards the cavity.Higher fluid viscosity and high fluid pumping rate are both able to attenuate the effect of the cavity.The frictional natural fracture connected to the cavity can significantly change the stress distribution around the cavity,thus dramatically deviates the hydraulic fracture from its original propagation direction.It is also found that the natural cavity existing between two adjacent fracturing stages will significantly influence the stress distribution between fractures and is more likely to result in irregular propagation paths compared to the case without a cavity. | Fang Shi Daobing Wang Xiaogang Chen | 2021 | Computer Modeling in Engineering & Sciences2021，，5： | 0 |
| 8 | Microstructures,Thermal and Mechanical Properties of Pure Tungsten—A Comparison Between Selective Laser Melting and Hot Rolling显示文摘A comparative study on the influence of different manufacturing methods(selective laser melting and hot rolling)on the microstructure,mechanical and thermal behaviours of tungsten(W)was presented for the first time.The results indicated that the selective laser melting(SLM)W exhibited a finer grain sizes,a lower strength ductility,hardness and thermal conductivity compared to hot-rolled W.The main reason for this result was that the laser underwent rapid heating and cooling when it was used to melt W powder with high energy density,resulting in large internal stress in the sample after manufacturing.Subsequently,the internal stress was released,leading to the generation of microcracks at the grain boundaries,thereby affecting the performance of SLM W samples.In addition,the higher fraction of high-angle grain boundaries(HAGBs)of SLM W was found to be the key factor for intrinsic brittleness.Because the HAGBs are the preferred crack paths,which could promote crack propagation and decrease fracture energy. | Chong Wang Daobing Chen Yan Zhou Zhuoming Xie Qianfeng Fang Shifeng Wen Chunze Yan | 2022 | Chinese Journal of Mechanical Engineering2022，35，3： | 0 |
| 9 | Vibrational Receptor of Scorpion(Heterometrus petersii):The Basitarsal Compound Slit Sensilla显示文摘Recently,micro-vibrational perception mechanisms of nocturnal arthropods such as scorpions and spiders are attracting increasingly more attention and research.The relevant micro-vibrational receptors are exquisite,in terms of their comprehensive performance such as sensitivity,stability,high anti-interference,and ultralow-power consumption.In this work,we find the Basitarsal Compound Slit Sensilla (BCSS) of scorpion (Heterometrus petersii) are composed of the crack-shaped slits as mechanosensory structure and can efficiently detect substrate-borne vibrational signal in complex natural environment.The study on microstructures and mechanical properties of tissue phases constituting the BCSS reveals that the strategy of tessellation is used to make crack-shaped slit amplify the tiny mechanical signal.In addition,the magnitude-frequency characteristics of electrophysiological signals caused by vibration stimulation with different frequencies indicate that the scorpion is sensitive to micro-vibrational signals at a certain frequency range.Meanwhile,the vibrational perception mechanism based on geometrical amplification and resonance is proposed to explain how scorpions detect the tiny biotic vibrational signal efficiently in noise environment.This finding not only promotes our further understanding of ultra-sensitive mechanism of the vibrational receptors,but also provides biological inspiration for the next generation of mechanosensor for a broad range of applications. | Kejun Wang Junqiu Zhang Linpeng Liu Daobing Chen Honglie Song Yinliang Wang Shichao Niu Zhiwu Han Luquan Ren | 2019 | Journal of Bionic Engineering2019，16，1： | 0 |
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