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| 1 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 2 | Pediatric restrictive cardiomyopathy due to a heterozygous mutation of the TNNI3 gene显示文摘Pediatric restrictive cardiomyopathy is rare and most commonly idiopathic in origin.Here,we applied a candidate gene approach and identified a missense mutation in the cardiac troponin I gene in a 12-year-old Chinese girl with restrictive cardiomyopathy.This study indicates that mutation in sarcomere protein genes may play an important role in idiopathic pediatric restrictive cardiomyopathy. | Yan Chen Shiwei Yang Jun Li Gannan Wang Yuming Qin Daowu Wang Kejiang Cao | 2014 | The Journal of Biomedical Research2014，28，1： | 3 |
| 3 | Design of readout electronics based on peak-holding circuit and multiplexer for a fast neutron spectrometer显示文摘Background Fast neutron detection is meaningful in many research fields such as space environment monitoring.A scintillating fiber array model for fast neutron detection was proposed and developed in 1980s.Aerospace applications of the model require electronics in small size.Purpose To design a dedicated electronic system to readout and process the 384-channel signals from scintillating fiber array,and to use the designed system to fabricate a neutron detector for aerospace applications.Methods With the method of nuclear recoil,fast neutron is detected by tracking recoil proton of n–p scatter in scintillating plastic fibers.Using the peak-holding circuits and multiplexers,the system size and power consumption were reduced.Results The detector fabricated with the designed system,had 34 cm×34 cm×27 cm mechanical size,20.4 kg weight,and 30.05W power consumption.Comparing to traditional waveform sampling electronics,the designed electronics was highly integrated and had a small size.The readout electronics also gave a better energy resolution of 39%in neutron detection,while the energy resolution was 43%in previous version.Conclusion In this study,a highly integrated readout electronic system was designed and verified.The detector using the system gave good performance.The designed electronics had potential development in fast neutron detection and other high energy physics detection system. | Liyang Sun Kai Zhuang Xiaoming Wang Fanjian Zeng Heng An Daowu Li Yuxiong Xue Zhiming Zhang Wei Zhou Yingjie Wang Baotong Feng Peilin Wang Xiaohui Li Jiale Cai Teng Tong Fanhui Meng Junguang Zhou Huan Huang Xuanhou Hu Xiubo Qin | 2018 | Radiation Detection Technology and Methods2018，2，1： | 1 |
| 4 | Compact MPPC-based coded aperture imaging camera for dual-particle detection显示文摘Purpose Fast neutrons and gamma-ray imaging detection is an effective way to detect and identify radioactive material in the field of nuclear security.A compact coded aperture imaging(CAI)camera was designed to be sensitive to both gamma and neutron radiation based on plastic scintillators and multi-pixel photon counters(MPPC).Methods MPPCs coupling with the 13×13 pixelated plastic scintillators one-to-one were utilized to reduce the scale of the CAI system while maintaining good positional performance.The symmetric charge division(SCD)circuit was adopted to reduce the 169 signals output from the MPPC array to 26.Each waveform was collected and processed with four Domino Ring Sampler 4(DRS4)chips and two 16-channel analog-to-digital converter(ADC)modules.As the pulse shapes of fast neutrons would be broadened after elastic scattering multiple times in the scintillators,the Anger-Logic method was applied to eliminate multiple elastic scattering events so that good pulse shape discrimination(PSD)performance can be achieved.Results The imaging and detection ability of the camerawas evaluated using the 241Am-Be(5.9×10^(5) n/s)neutron source and 137Cs(370 MBq)gammasource.The camera can be used to detect fast neutrons(0.5–10 MeV)and gammarays(0.2–2.5MeV).Furthermore,it can implement efficient neutron/gamma PSD capabilities in the mixed-field environment.The figure of merit(FOM)of the camera calculated at 400keVee energy cut is 0.93.Conclusion A compact MPPC-based CAI camera was designed to detect and discriminate fast neutrons and gamma rays.Its good PSD performance was well suited to distinguish fast neutrons from gamma rays in a dual-particle environment.The portable design makes it promising for complex monitoring scenarios in nuclear security. | Jing Guo Xiaoyu Pang Jiale Cai Daowu Li Xiaoming Wang Xuanhou Hu Yue Yu Shuangquan Liu Xiuzuo Liang Yiwen Zhang Lei Shuai Long Wei | 2021 | Radiation Detection Technology and Methods2021，5，1： | 1 |
| 5 | A real-time peak-detection approach for nuclear detection and its implementation on an FPGA显示文摘Introduction Detecting a pulse correctly is a key process in nuclear detection.Because the radiation emission is a random process,it is hard to design a suitable peak-detection approach in FPGA.The error detection will influence the final energy spectrum and flood histogram.In order to improve the result of nuclear detection,this paper proposes a novel method for nuclear signal peak-detection,which can improve both the effective counting rate and the quality of pulses in real-time.Methods The main method is to establish a normalized reference pulse regardless of waveform through the least squares method.By calculating the loss between the incoming data stream and normalized reference pulse,this algorithm retains the pulses whose loss is below the threshold.We select the threshold based on statistical methods.The algorithm is implemented on field programmable gate array(FPGA)successfully,and this process is able to work in real-time.Conclusion The result shows that the effective counting rate can improve about 19.8%and more than 99%pile-up and error pulses will be suppressed.By analyzing reserved pulses,the energy spectrum and flood histogram could be well rectified.The energy resolution increases 11%compared with traditional algorithm.Furthermore,due to this new algorithm,the low-energy threshold can be lower. | Yao Yang Daowu Li Yan Li Jipeng Zhang Tingting Hu Yan Li Long Wei | 2020 | Radiation Detection Technology and Methods2020，4，2： | 0 |
| 6 | An efficient method and system for simultaneously measuring the performance of vast scintillating materials显示文摘A method and system for automatically and simultaneously measuring the light output of multiple scintillators,or each scintillating unit of an array,were developed.Using a large area flat panel PSPMT H8500,the light output and energy resolution were obtained automatically by comparing with reference scintillators or array using an Energy Table,Look-up Table and energy spectrum data.The aim of developing an efficient performance evaluation of scintillators was achieved.Using the method,a scintillator performance testing system was set up and six LYSO crystals and a 3×3 LYSO array were measured.The results showed that the light output and energy resolution were accurately measured automatically.The deviation of repeat measurements for the same sample was not more than 2%,and the nonlinear deviation of the system was not more than 3%.The system is suitable for measuring the performance of crystals,especially where the mass measurement of crystals and arrays is required. | CHEN Yan ZHANG Zhiming LI Daowu SHUAI Lei HUANG Xianchao TANG Haohui LI Ting ZHUANG Kai WANG yingjie LIU Yantao ZHANG Yiwen CHAI Pei LIU Shuangquan ZHU Meiling WANG Baoyi WEI Long | 2012 | Nuclear Science and Techniques2012，23，3： | 0 |
| 7 | Image reconstruction for the coded aperture system in nuclear safety and security using a Monte Carlo-based system matrix显示文摘Purpose Accurate localization of radioactive materials is critical to nuclear safety and nuclear security.A coded aperture imaging system provides a visualization solution.However,the correlation method has poor reconstruction performance for sources with low counts and for extended sources.Methods In this study,a Monte Carlo optimization-based MLEM algorithm(MC-MLEM)is proposed.The system matrix was obtained by accurate Monte Carlo simulation,so the physical effects such as mask penetration that affect the imaging process were taken into account in the MLEM algorithm.In the simulation process,the normalization of the system matrix was realized by controlling the source at different position of the source plane to have the same activity and emission angle.Results The experimental results showed that compared with the correlation method,the MC-MLEM algorithm could improve the signal-to-noise ratio and angular resolution and locate the source position quickly and accurately under low count conditions.Furthermore,the MC-MLEM algorithm could reconstruct the shape of the extended source and the expected activity ratio of cold-hot sources with large activity differences.Conclusion The MC-MLEM algorithm improved the imaging results and enhanced the reconstruction performance. | Yue Yu Xiaoli Sun Zhiming Zhang Shuangquan Liu Xiuzuo Liang Daowu Li Lei Shuai Tingting Hu Long Wei | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 8 | GhWDL3 is involved in the formation and development of fiber cell morphology in upland cotton(Gossypium hirsutum L.)显示文摘Background Cotton fiber is a model tissue for studying microtubule-associated proteins(MAPs).The Xklp2(TPX2)proteins that belong to the novel MAPs member mainly participate in the formation and development of microtubule(MT).However,there is a lack of studies concerning the systematic characterization of the TPX2 genes family in cotton.Therefore,the identification and portrayal of G.hirsutum TPX2 genes can provide key targets for molecular manipula-tion in the breeding of cotton fiber improvement.Result In this study,TPX2 family genes were classified into two distinct subclasses TPXLs and MAP genes WAVE DAMP-ENED2-LIKE(WDLs)and quite conservative in quantity.GhWDL3 was significantly up-regulated in 15 days post anthe-sis fibers of ZRI-015(an upland cotton with longer and stronger fiber).GhWDL3 promotes all stem hairs to become straight when overexpressed in Arabidopsis,which may indirectly regulate cotton fiber cell morphology during fiber development.Virus induced gene silencing(VIGS)results showed that GhWDL3 inhibited fiber cell elongation at fiber development periods through regulating the expression of cell wall related genes.Conclusion These results reveal that GhWDL3 regulated cotton fiber cell elongation and provide crucial information for the further investigation in the regulatory mechanisms/networks of cotton fiber length. | CHEN Baojun TIAN Zailong FU Guoyong ZHANG Ai SUN Yaru WANG Jingjing PAN Zhaoe LI Hongge HU Daowu XIA Yingying HE Shoupu DU Xiongming | 2024 | Journal of Cotton Research2024，7，1： | 0 |
| 9 | A genome-wide association study of lateral root number for Asian cotton(Gossypium arboreum L.)显示文摘Background:The lateral root is one of the most important organs that constitute the root architecture system in plants.It can directly affect the contact area between plants and soil and plays an important role in plant structural support and nutrient absorption.Optimizing root architecture systems can greatly increase crop yields.This study was designed to identify the molecular markers and candidate genes associated with lateral root development in cotton and to evaluate correlations with yield and disease traits.Result:The number of lateral roots for 14-day old seedlings was recorded for 215 Gossypium arboreum accessions.A correlation analysis showed that the number of lateral roots positively correlates with the sympodial branch node and seed index traits,but negatively correlates with lint percentage.A Genome-wide association study(GWAS)identified 18 significant SNPs with 19 candidate genes associated with the lateral root number.Expression analysis identified three genes(FLA 12,WRKY29,and RBOHA)associated with lateral root development.Conclusion:GWAS an alysis identified key SNPs and candidate gen esfor lateral root number,a nd gen es of FLA 12,WRKY29,and RBOHA may play a pivotal role in lateral root development in Asian cotton. | HU Daowu HE Shoupu SUN Gaofei JIA Yinhua GENG Xiaoli WANG Liru PAN Zhaoe CHEN Baojun LI Hongge ZUBAIR Iqbal WANG Xiaoyang ZHAO Zibo GE Yuting PANG Baoyin DU Xiongming | 2022 | Journal of Cotton Research2022，5，2： | 0 |
| 10 | Simulation research on time resolution based on Cherenkov radiation显示文摘Purpose A faster time performance can be achieved by focusing on prompt emitted photons,such as Cherenkov photons.In this study,the time fluctuations of Cherenkov photons transmission in the three Cherenkov radiators were first simulated,and we evaluated the detector performance and discussed ways to improve the coincidence time resolution(CTR)results for the detector with the three radiators.Finally,we compared detection efficiency of Cherenkov radiation in three radiators.Methods In this work,we recorded the step-by-step information of Cherenkov photons and the electrons that produced them in the radiator,information of photons on the photon outputting surface,and the step-by-step information tracing of the par-ent charged particles(electrons)to evaluate the factors influencing the performance time of the detector based on Geant4.Specially,we usually use a photon amplitude timing in the experimental implements,and the arrival time of an event is defined as the arrival time of the first photon of the event accordingly.Results The time fluctuations of Cherenkov photons transmission in the three Cherenkov radiators with a 5 mm length were simulated as 28.5 ps for PbF,40.1 ps for PbWO_(4),and 24.7 ps for Al_(2)O_(3).After considering other factors such as quantum efficiency(QE)of 30%and transit time spread(TTS)of 10 ps from the process of practical electronics,the CTR of a pair of single-pixel detectors were 56.6 ps for PbF_(2),78.8 ps for PbWO_(4),and 46.3 ps for Al_(2)O_(3) with a thickness of 5 mm.The detection efficiency of PbF_(2) is 32.25%,PbWO_(4) of 31.91%and Al_(2)O_(3) of 8.14%in the case of 5 mm length.Conclusions The simulation results indicated that using the Cherenkov photons produced in PbF_(2),PbWO_(4),Al_(2)O_(3) for detec-tor timing can obtain good CTR results.In this study,it demonstrates that it is possible to achieve a pretty good CTR with an improved QE and a reduced TTS of the photodetector. | Xiaorou Han Long Wei Xianchao Huang Haohui Tang Yingjie Wang Wen He Daowu Li Zhiming Zhang | 2021 | Radiation Detection Technology and Methods2021，5，3： | 0 |
| 11 | Correlation analysis of stem hardness traits with fiber and yield-related traits in core collections of Gossypium hirsutum显示文摘Background:Stem hardness is one of the major influencing factors for plant architecture in upland cotton(Gossypium hirsutum L.).Evaluating hardness phenotypic traits is very important for the selection of elite lines for resistance to lodging in Gossypium hirsutum L.Cotton breeders are interested in using diverse genotypes to enhance fiber quality and high-yield.Few pieces of research for hardness and its relationship with fiber quality and yield were found.This study was designed to find the relationship of stem hardness traits with fiber quality and yield contributing traits of upland cotton.Results:Experiments were carried out to measure the bending,acupuncture,and compression properties of the stem from a collection of upland cotton genotypes,comprising 237 accessions.The results showed that the genotypic difference in stem hardness was highly significant among the genotypes,and the stem hardness traits(BL,BU,AL,AU,CL,and CU)have a positive association with fiber quality traits and yield-related traits.Statistical analyses of the results showed that in descriptive statistics result bending(BL,BU)has a maximum coefficient of variance,but fiber length and fiber strength have less coefficient of variance among the genotypes.Principal component analysis(PCA)trimmed quantitative characters into nine principal components.The first nine principal components(PC)with Eigenvalues>1 explained 86%of the variation among 237 accessions of cotton.Both 2017 and 2018,PCA results indicated that BL,BU,FL,FE,and LI contributed to their variability in PC1,and BU,AU,CU,FD,LP,and FWPB have shown their variability in PC2.Conclusion:We describe here the systematic study of the mechanism involved in the regulation of enhancing fiber quality and yield by stem bending strength,acupuncture,and compression properties of G.hirsutum. | RAZA Irum HU Daowu AHMAD Adeel LI Hongge HE Shoupu NAZIR Mian Faisal WANG Xiaoyang JIA Yinhua PAN Zhaoe ZHANG Peng YASIR Muhammad IQBAL Muhammad Shahid GENG Xiaoli WANG Liru PANG Baoyin DU Xiongming | 2021 | Journal of Cotton Research2021，4，1： | 0 |
| 12 | Design of a high-sampling-rate electronic module for array-detector positron annihilation lifetime measurements显示文摘Introduction In this study,a high-time-resolution electronic module with a high channel density and low power consumption was designed for the measurement of the multi-detector array positron annihilation lifetimes.This electronic module consisted of 32 input channels,and each channel provided a high sampling rate up to 5.12 GSPS based on a Domino Ring Sampler 4(DRS4)chip.Compared to the high-speed flash analog-digital converter(FADC),DRS4 chip has a higher channel density with an affordable lower price and power consumption.Methods The developed electronic module was also capable of real-time data analysis for directly extracting the time information of input signals at the data acquisition site,thereby significantly decreasing the data rate.The digital constant fraction discriminator(DCFD)algorithm was implemented in the field programmable gate array(FPGA)for performing the time pick-up.Results The coincidence time resolution of the electronic module was measured,and the test results revealed a value of 26 ps.A prototypical 16-pixel detector module of the multi-detector system was evaluated using this electronic module,and the coincidence time resolution of the prototypical module was 411.84 ps.Conclusions The electronic module was confirmed to satisfy the severe requirements of the multi-array-detector positron annihilation lifetime measurement system.It was also suitable for other high-time-resolution,high-channel-density,costeffective,and low-power-consumption applications. | Jiale Cai Daowu Li Yingjie Wang Zhiming Zhang Peilin Wang Haohui Tang Baoyi Wang Xingzhong Cao Fuyan Liu Long Wei | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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