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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Current and future predicting potential areas of Oxytenanthera abyssinica(A.Richard)using MaxEnt model under climate change in Northern Ethiopia显示文摘Introduction:Climate change will either improve,reduce,or shift its appropriate climatic habitat of a particular species,which could result in shifts from its geographical range.Predicting the potential distribution through MaxEnt modeling has been developed as an appropriate tool for assessing habitat distribution and resource conservation to protect bamboo species.Methods:Our objective is to model the current and future distribution of Oxytenanthera abyssinica(A.Richard)based on three representative concentration pathways(RCP)(RCP2.6,RCP4.5,and RCP8.5)for 2050s and 2070s using a maximum entropy model(MaxEnt)in Northern Ethiopia.For modeling procedure,77 occurrence records and 11 variables were retained to simulate the current and future distributions of Oxytenanthera abyssinica in Northern Ethiopia.To evaluate the performance of the model,the area under the receiver operating characteristic(ROC)curve(AUC)was used.Results:All of the AUCs(area under curves)were greater than 0.900,thereby placing these models in the“excellent”category.The jackknife test also showed that precipitation of the coldest quarter(Bio19)and precipitation of the warmest quarter(Bio18)contributed 66.8%and 54.7%to the model.From the area of current distribution,1367.51 km2(2.52%),7226.28 km2(13.29%),and 5377.26 km2(9.89%)of the study area were recognized as high,good,and moderate potential habitats of Oxytenanthera abyssinica in Northern Ethiopia,and the high potential area was mainly concentrated in Tanqua Abergele(0.70%),Kola Temben(0.65%),Tselemti(0.60%),and Tsegede(0.31%).Kafta Humera was also the largest good potential area,which accounts for 2.75%.Compared to the current distribution,the total area of the high potential regions and good potential regions for Oxytenanthera abyssinica under the three RCPs(RCP2.6,RCP4.5,and RCP8.5)would increase in the 2050s and 2070s.However,the total area of the least potential regions under the three RCPs(RCP2.6,RCP4.5,and RCP8.5)in 2050s and 2070s would decrease.Conclusion:This study can provide vital information for the protection,management,and sustainable use of Oxytenanthera abyssinica,the resource to address the global climate challenges. | Yikunoamlak Gebrewahid Selemawi Abrehe Esayas Meresa Gebru Eyasu Kiros Abay Gebrehiwot Gebreab Kiros Kidanemariam Gezu Adissu Gebrekidan Abreha Girmay Darcha | 2020 | Ecological Processes2020，9，1： | 4 |
| 3 | HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometrio- sis, uterine fibromas or unexplained infertility 显示文摘 | Matsuzaki S Canis M Darcha C | 2009 | Hum Reprod2009，24，12： | 1 |
| 4 | Co-operation between the AKT and ERK signaling pathways may support growth of deep endometriosis in a fibrotic microenvironment in vitro显示文摘 | Matsuzaki S Darcha C | 2015 | Hum Reprod2015，30，： | 1 |
| 5 | HOXA-10 expression in the midsecretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility 显示文摘 | MatsuzakiS Canis M Darcha C | 2009 | Hum Reprod2009，24，12： | 1 |
| 6 | Increased mast cell density in peritonealendometriosis compared with eutopic endometriumwith endometriosis 显示文摘 | MATSUZAKI S CANIS M DARCHA C | 1998 | Am J Reprod Immunol1998，40，4： | 1 |
| 7 | Cyelooxygenase-2 selective inhibitor prevents implantation of eutopie endometrium to ectopie sites in rats显示文摘 | MATSUZAKI S CANIS M DARCHA C | 2004 | Fertil Steril2004，82，6： | 1 |
| 8 | Analysis of matrix metalloproteinase-7 expression in eutopie and eetopie endometrium samples from patients with different forms of endometriosi显示文摘 | Matsuzaki S Maleysson E Darcha C | 2010 | Hum Reprod2010，25，3： | 1 |
| 9 | Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endo- metrium to ectopic sites in rats 显示文摘 | Matsuzaki S Canis M Darcha C | 2004 | Fertil Steril2004，82，6： | 1 |
| 10 | Analysis of risk factors for the removal of normal ovarian tissue during lap- aroscopic cystectomy for ovarian endometriosis 显示文摘 | Matsuzaki S Houlle C Darcha C | 2009 | Hum Reprod2009，24，6： | 1 |
| 11 | Increased mast cell density in peritoneal endometriosis compared with eutopic endometrium with endometriosis 显示文摘 | MATSAZAKI S CANIS M DARCHA C | 1998 | Am J Reprod Immunol1998，40，4： | 1 |
| 12 | Analysis of risk factors for the removal of normal ovarian tissue during laparoscopic cystectomy for o- varian endometriosis显示文摘 | Matsuzaki S Houlle C Darcha C | 2009 | Hum Reprod2009，24，6： | 1 |
| 13 | Analysis of matrix metalloproteinase- 7 expression in eutopic and ectopic en- dometrium samples from patients with different forms of en- dometriosis 显示文摘 | Matsuzaki S Maleysson E Darcha C | | Hum Reprod0，25，3： | 1 |
| 14 | Human ovarian tissue from cortex surrounding benign cysts: a model to study ovarian tissue cryopreservation显示文摘 | Schubert B Canis M Darcha C | 2005 | Hum Reprod2005，20，7： | 1 |
| 15 | Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats显示文摘 | Matsuzaki S Canis M Darcha C | 2004 | Fertil Steril2004，82，： | 1 |
| 16 | Impaired Down-Regulation of E-Cadherin and β-Catenin Protein Expression in Endometrial Epithelial Cells in the Mid-Secretory Endometrium of Infertile Patients with Endometriosis显示文摘 | Sachiko Matsuzaki Claude Darcha Elodie Maleysson Michel Canis Gérard Mage | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，7： | 1 |
| 17 | Analysis of risk factors for the removal of normal ovarian tissue during laparoscopic cystectomy for ovarian endometriosis显示文摘 | Matsuzaki S Houlle C Darcha C | | 0，，： | 1 |
| 18 | HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility 显示文摘 | Matsuzaki S Canis M Darcha C | 2009 | Hum Reprod2009，24，12： | 1 |
| 19 | Trophoblastic gestational disease: a placental site trophoblastic tumor and an epithelioid trophoblastic tumor 显示文摘 | Bouchet-Mishellany F Ledoux-Pilon A Darcha C | 2004 | Ann Pathol2004，24，2： | 1 |
| 20 | Analysis of matrix metaHopro- teinase-7 expression in eutopic and ectopic endometrium samples from patients with different forms of endometriosis 显示文摘 | Matsuzaki S Maleysson E Darcha C | 2010 | Hum Reprod2010，25，3： | 1 |
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