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1篇 您的检索式：作者名="Darrell D.Mousseau"

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		题名	作者	年代	出处	被引量
	1	Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits.	Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu	2014	Neuroscience Bulletin2014，30，6：	7

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