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| 1 | Microbial Impacts to the Near-Field Environment Geochemistry: a model for estimating microbial communities in repository drifts at Yucca Mountain 显示文摘 | Darren M J Thomas FE Joanne H | 2003 | Journal of Contaminant Hydrology2003，62，： | 1 |
| 2 | Tracking with vir- tual slides: a tool to study diagnostic error in histopathol- ogy显示文摘 | Darren T Chee H L Derek M | 2009 | Histopathology2009，55，1： | 1 |
| 3 | Outcomes following liver transplantation in intensive care unit patients显示文摘AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient survival.METHODS:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December 2010.RESULTS:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and norepinephrine.Sixteen ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to transplantation.Twenty-five ICU patients (64%) required dialysis preoperatively.At 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU patients.Patient survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU patients.When formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable analysis.These findings were consistent in multivariable analysis.Although not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (RR:4.19,P=0.033).Graft survival and patient survival were not significantly worse for patients on mechanical ventilation (RR:0.91,P=0.88 in graft loss;RR:0.69,P=0.56 in death) or patients on vasopressors (RR:1.06,P=0.93 in graft loss;RR:1.24,P=0.74 in death) immediately prior to LT.Trends toward lower graft survival and patient survival were observed for patients on dialysis immediately before LT,however these findings did not approach statistical significance (RR:1.70,P=0.43 in graft loss;RR:1.46,P=0.58 in death).CONCLUSION:Although ICU patients when compared to non-ICU patients have lower survivals,outcomes are still acceptable.Pre-transplant ventilation,hemodialysis,and vasopressors were not associated with adverse outcomes. | Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen | 2013 | World Journal of Hepatology2013，5，1： | 1 |
| 4 | A General Approach to the Galanthamine Ring System显示文摘 | Philip J P Mark D C Darren M H | 2001 | Tetrahedron Letters2001，42，11： | 1 |
| 5 | Late-onset deep prosthetic infection following mesh repair of inguinal hernia 显示文摘 | Darren M leremy P Erik H | 1998 | Am J Surg1998，176，1： | 1 |
| 6 | Fault detection for robot manipulators with parametric uncertainty: A Prediction-Error-Based Approach 显示文摘 | WARREN E D DARREN M D JOHN P H | 2000 | IEEE Transactions on Robotics and Automation2000，16，6： | 1 |
| 7 | A new class of robust control laws for tracking of robots显示文摘 | Qu Z H Darren D M Lim S Y | 1994 | The international journal of robotics research1994，13，4： | 1 |
| 8 | Late-onset deep prosthetic infection following mesh repair of inguinal hernia 显示文摘 | Darren M Jeremy P Enk H | 1998 | Am J Surg1998，176，1： | 1 |
| 9 | Late -onsetdeep prosthetic in - fection followingmesh repair of inguinalhernia显示文摘 | Darren M Jeremy P Erik H | 1998 | Am J Surg1998，176，1： | 1 |
| 10 | Consolidation of combustion- synthesized titanium diboride-based materials显示文摘 | DARREN A H MARC A M | 1995 | J Am Ceram Soc1995，78，2： | 1 |
| 11 | Consolidation of combustion- synthesized titanium diboride- based materials显示文摘 | DARREN A H MARC A M | 1995 | Journal of the American Ceramic Society1995，78，2： | 1 |
| 12 | Microwave absorption by polyaniline-carbon nanotube composites 显示文摘 | Darren A M Trisha H | 2006 | Synthetic Metals2006，，156： | 1 |
| 13 | Arthroseopie treatment of osteoehondritis disseeans of the talus显示文摘 | Siow H M Darren T K J Mitra A K | 2004 | Foot Ankle Surg2004，10，1： | 1 |
| 14 | Microwave absorptioh by polyaniline - carbon nanotube composites显示文摘 | Darren A M Trisha H | 2006 | Synthetic Metals2006，156，： | 1 |
| 15 | Late-Onset deepprosthetic infection following mesh repair of insu-hernia显示文摘 | Darren M Jeremy P Erik H | 1998 | Am J Surg1998，176，1： | 1 |
| 16 | Clinical utilities and end-user experience of pharmacogenomics:39 mo of clinical implementation experience in an Australian hospital setting显示文摘BACKGROUND Pharmacogenomics(PG)testing is under-utilised in Australia.Our research provides Australia-specific data on the perspectives of patients who have had PG testing and those of the clinicians involved in their care,with the aim to inform wider adoption of PG into routine clinical practice.AIM To investigate the frequency of actionable drug gene interactions and assess the perceived utility of PG among patients and clinicians.METHODS We conducted a retrospective audit of PG undertaken by 100 patients at an Australian public hospital genetics service from 2018 to 2021.Via electronic surveys we compared and contrasted the experience,understanding and usage of results between these patients and their clinicians.RESULTS Of 100 patients who had PG,84% were taking prescription medications,of which 67% were taking medications with actionable drug-gene interactions.Twenty-five out of 81 invited patients and 17 out of 89 invited clinicians completed the surveys.Sixty-eight percent of patients understood their PG results and 48% had medications changed following testing.Paired patient-clinician surveys showed patient-perceived utility and experience was positive,contrasting their clinicians’hesitancy on PG adoption who identified insufficient education/training,lack of clinical support,test turnaround time and cost as barriers to adoption.CONCLUSION Our dichotomous findings between the perspectives of our patient and clinician cohorts suggest the uptake of PG is likely to be driven by patients and clinicians need to be prepared to provide information and guidance to their patients. | Rosalind Moxham Andrew Tjokrowidjaja Sophie Devery Renee Smyth Alison McLean Darren M Roberts Kathy H C Wu | 2023 | World Journal of Medical Genetics2023，11，4： | 0 |
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