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| 1 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 2 | Evaluation of the role of P - glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells 显示文摘 | Lynn WM David AA Ellen BW | 2005 | Neuropharmacol2005，49，： | 1 |
| 3 | Soil dissipation and biological activity of metolachlor and S-metolachlor in five soils显示文摘 | Dale LS Galen B David BW | 2006 | Pest Manag Science2006，62，： | 1 |
| 4 | Interleukin 33:a switch-hitting cytokine显示文摘 | Daniel OV David BW | 2014 | Curr Opin Immunol2014，28，5： | 1 |
| 5 | DNA vaccines: ready for prime time? 显示文摘 | Michele AK David BW | 2008 | Nature Reviews Genetics2008，9，： | 1 |
| 6 | Predictors of Lamotrigine- associated rash显示文摘 | Lawrence JH David BW Richard B | 2006 | Epilepsia2006，47，2： | 1 |
| 7 | Quantifying bacterial population dynamics in compost using 16S rRNA gene probes显示文摘 | Patrick DS Anthony GH David BW | 2005 | Appl Microbiol Biotech2005，66，4： | 1 |
| 8 | Soil dissipation and biological activity of metolachlor and S-metolachlor in five soils显示文摘 | Dale LS Galen B David BW | 2006 | Pest Manag Science2006，62，： | 1 |
| 9 | Prokaryotes: Theunseen majority显示文摘 | William BW David CC William JW | 1998 | Proceedings of the National Academyof Sciences of the United States of America1998，95，12： | 1 |
| 10 | Modulating the immune response togenetic immunization显示文摘 | Adam DC Jean DB David BW | 1998 | The FASEB Journal1998，12，15： | 1 |
| 11 | Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alla L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 12 | Probing the catalytic mecha-nism of prephenate dehydratase by site-directedmutagenesis of the Escherichia coli P-protein dehydratase domain显示文摘 | Zhang S David BW Ganem B | 2000 | Biochem-istry2000，39，： | 1 |
| 13 | Expression of the neu Gene-encoded protein (p185 neu ) in human non small cell carcinomas of the lung 显示文摘 | David BW Joanne N | 1990 | Cancer Res1990，50，15： | 1 |
| 14 | Associations between retinal microvaseular abnormalities and declining renal function in the elderly population: the Cardiovascular Health Study显示文摘 | Matthew SE David BW Timothy EC | 2005 | Am J Kidney Dis2005，46，： | 1 |
| 15 | Predictors of Lam- otriginmassociated rash显示文摘 | Lawrence JH David BW Richard B etal | 2006 | Epilepsia2006，47，2： | 1 |
| 16 | Green tea extract as a cryoprotectant additive to preserve the motility and DNA integrity of human spermatozoa显示文摘Cryopreservation impairs sperm quality and functions,including motility and DNA integrity.Antioxidant additives in sperm freezing media have previously brought improvements in postthawed sperm quality.Green tea extract(GTE)is widely considered as an excellent antioxidant,and its beneficial role has been proven in other human cells.This study aims to evaluate the GTE as a potential additive in cryopreservation media of human spermatozoa.In part one,the semen of 20 normozoospermic men was used to optimize the concentration of GTE that maintains sperm motility and DNA integrity against oxidative stress,induced by hydrogen peroxide(H_(2)O_(2)).Spermatozoa were treated with GTE at different concentrations before incubation with H_(2)O_(2).In part two,the semen of 45 patients was cryopreserved with or without 1.0 ng ml^(-1)GTE.After 2 weeks,the semen was thawed,and the effect on sperm motility and DNA fragmentation was observed.Our data showed that GTE significantly protected sperm motility and DNA integrity against oxidative stress induced by H_(2)O_(2)when added at a final concentration of 1.0 ng ml^(-1).We found that the addition of 1.0 ng ml^(-1)GTE to cryopreservation media significantly increased sperm motility and DNA integrity(both P<0.05).More interestingly,patients with high sperm DNA damage benefited similarly from the GTE supplementation.However,there was no significant change in the reactive oxygen species(ROS)level.In conclusion,supplementing sperm freezing media with GTE has a significant protective effect on human sperm motility and DNA integrity,which may be of clinical interest. | Odai AM Alqawasmeh Mingpeng Zhao Carol PS Chan Maran BW Leung Ki C Chow Nikunj Agarwal Jennifer SM Mak Chi C Wang Chi P Pang Tin C Li Wai K Chu David YL Chan | 2021 | Asian Journal of Andrology2021，23，2： | 0 |
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