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您的检索式：作者名="David J.Beech"
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| 1 | 人血管内皮细胞特异性表达TMEM 16B显示文摘目的探讨人血管内皮细胞上TMEM16A、TMEM16B蛋白的表达情况,并初步探讨后者的功能。方法采用实时PCR方法检测人脐带静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)中TMEM16A、TMEM16B的基因表达情况。采用Western-Blot及免疫荧光染色方法进一步证实HUVECs中TMEM16B的表达情况。Fura-2am标记HUVECs后采用Flex-station检测细胞内钙变化情况。结果 HUVECs细胞表达TMEM16B,而未表达TMEM16A。Western-Blot及免疫荧光方法从蛋白水平证明HUVECs表达TMEM16B。在使用TMEM16B的si RNA干预HUVECs后,无论是有钙及无钙溶液,在50 n M血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)刺激下,钙浓度峰值均增大,而且峰值出现时间提前。结论人血管内皮细胞特异性表达TMEM16B,生理情况下TMEM16B对VEGF刺激引起的Ca2+的释放过程可能起着负向调节作用。 | 付兆君 刘红巾 程军 徐先荣 David J.Beech | 2015 | 空军医学杂志2015，31，3： | 1 |
| 2 | Cyclooxygenase‐2 Expression in Murine and Human Nonmelanoma Skin Cancers: Implications for Therapeutic Approaches显示文摘 | Kathy P.An MohammadAthar XiuweiTang Santosh K.Katiyar JustinRusso J.Beech MichelleAszterbaum LevyKopelovich Ervin H.Epstein HasanMukhtar David R.Bickers | 2007 | Photochemistry and Photobiology2007，，1： | 1 |
| 3 | RNA and the PIEZO force sensor显示文摘The discovery of the PIEZO force-sensing ion channels was an important advance in recent years,leading to exciting new knowledge and fields of inquiry.An interesting article published by Sugisawa et al.in Cell unexpectedly suggests PIEZO1 channels as RNA rather than force sensors in enterochromaffin cells,with important implications for microbiome response and gut motility mediated by 5-HT. | David J.Beech Laeticia Lichtenstein | 2020 | Cell Research2020，30，10： | 0 |
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