6篇
您的检索式：作者名="David Posada"
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| 1 | Tacrolimus confers lower acute rejection rates and better renal allograft survival compared to cyclosporine显示文摘AIM To compare the impact of tacrolimus(FK) and cyclosporine(CYA) on acute rejection and graft survival and to assess the predominant causes of graft loss between patients receiving these two calcineurin inhibitors(CNIs).METHODS Retrospective review of 1835 patients who received a kidney transplant(KTX) between 1999-2012. Patients were grouped based on initial CNI utilized: 1195 in FK group, 640 in CYA group. Data on baseline characteristics, clinical outcomes, and causes of graft loss in both groups were analyzed. RESULTS Cumulative acute rejection rates were 14% in the FK vs 24% in the CYA group. Despite more marginal donor characteristics in the FK group, these patients had better graft survival rates compared to the CYA group. Three and five year graft survival rates were 88% and 84% respectively in the FK group compared to 79% and 70% respectively in the CYA group(P < 0.001). After multivariate analysis, which controlled for confounders, FK use was a strong predictor for lower acute rejectionrates [odds ratio(OR) 0.60, 95%CI: 0.45-0.79] and better renal allograft survival(OR 0.740, 95%CI: 0.58-0.94). Death with a functioning graft was the most common cause of graft loss in both groups. Common causes of death included cardiovascular disease, infections, and malignancies. Chronic allograft nephropathy was also found to be an important cause of graft loss, being more prevalent in the CYA group. CONCLUSION The use of FK-based maintenance immunosuppression therapy is associated with a significantly lower rate of acute rejection and better graft survival compared to CYA-based regimen. Individualizing immunosuppression through risk-stratified CNI choice may lead to improved outcomes across all spectra of KTX patients. | Mahmoud Kamel Manish Kadian Titte Srinivas David Taber Maria Aurora Posadas Salas | 2016 | World Journal of Transplantation2016，6，4： | 2 |
| 2 | Recombination favors the evolution of drug resistance in HIV-1 during antiretroviral therapy显示文摘 | Antonio Carvajal-Rodríguez Keith A. Crandall David Posada | 2007 | Infection Genetics and Evolution2007，，4： | 1 |
| 3 | Automated Phylogenetic Detection of Recombination Using a Genetic Algorithm显示文摘 | Sergei L Kosakovsky Pond David Posada Michael B Gravenor | 2006 | Mol Biol Evol2006，23，10： | 1 |
| 4 | Intraspecific gene genealogies: trees grafting into networks显示文摘 | David Posada Keith A. Crandall | 2000 | Trends in Ecology & Evolution2000，，1： | 1 |
| 5 | Intraspecific gene genealogies: trees grafting into networks显示文摘 | David Posada Keith A. Crandall | 2000 | Trends in Ecology & Evolution2000，，： | 1 |
| 6 | 他汀降脂治疗的药物遗传学研究显示文摘背景:胆固醇合成、吸收和转运相关基因的多态性也许会影响他汀的疗效。 | Daniel I. Chasman David Posada Lakshman Subrahmanyan 崔艳丽(译) 赵秀丽(校) | 2005 | 美国医学会杂志(中文版)2005，24，4： | 0 |
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