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2篇 您的检索式：作者名="David W. McComb"

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		题名	作者	年代	出处	被引量
	1	Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is one type of the most aggressive breast can cers with poor prog no sis.It is of great urgency to develop new therapeutics for treati ng TNBC.Based on curre nt treatment guideline and genetic informatio n of TNBC,a combi nation al therapy platform in tegrati ng chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy.In this study,we developed paclitaxel amino lipid(PAL)derived nanoparticles(NPs)to incorporate both chemotherapy drugs and P53 mRNA.The PAL P53 mRNA NPs showed superior properties compared to Abraxane? and Lipusu? used in the clinic including high paclitaxel loading capacity(24 wt.%,calculated by paclitaxel in PAL),PAL encapsulation efficiency(94.7%±6.8%)and mRNA encapsulation efficiency(88.7%±0.7%).Meanwhile,these NPs displayed synergetic cytotoxicity of paclitaxel and P53 mRNA in cultured TNBC cells.More importantly,we demonstrated in vivo anti-tumor efficacy of PAL P53 mRNA NPs in an orthotopic TNBC mouse model.Overall,these chemotherapy drugs derived mRNA NPs provide a new platform to integrate chemotherapy and personalized medicine using tumor genetic information,and therefore represent a promising approach for TNBC treatment.	Chengxiang Zhang Xinfu Zhang Weiyu Zhao Chunxi Zeng Wenqing Li Bin Li Xiao Luo Junan Li Justin Jiang Binbin Deng David W. McComb Yizhou Dong	2019	Nano Research2019，12，4：	1
	2	Co-delivery of mRNA and SPIONs through amino-ester nanomaterials显示文摘	Xiao Luo Weiyu Zhao Bin Li Xinfu Zhang Chengxiang Zhang Anna Bratas Binbin Deng David W. McComb Yizhou Dong	2018	Nano Research2018，11，10：	1

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