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| 1 | Two strategies for prevention of cytomegalovirus infections after liver transplantation显示文摘AIM: To analyze differences in patients' clinical course, we compared two regimes of either preemptive therapy or prophylaxis after liver transplantation.METHODS: This retrospective study was reviewed and approved by the institutional review board of the University of Leipzig. Cytomegalovirus(CMV) prophylaxis with valganciclovir hydrochloride for liver transplant recipients was replaced by a preemptive strategy in October 2009. We retrospectively compared liver transplant recipients 2 years before and after October 2009. During the first period, all patients received valganciclovir daily. During the second period all patients included in the analysis were treated following a preemptive strategy. Outcomes included one year survival and therapeutic intervention due to CMV viremia or infection.RESULTS: Between 2007 and 2010 n = 226 patients underwent liver transplantation in our center. n = 55 patients were D^+/R^- high risk recipients and were excluded from further analysis. A further 43 patients had to be excluded since CMV prophylaxis/preemptive strategy was not followed although there was no clinical reason for the deviation. Of the remaining 128 patients whose data were analyzed, 60 receivedprophylaxis and 68 were treated following a preemptive strategy. The difference in overall mortality was not significant, nor was it significant for one-year mortality where it was 10%(95%CI: 8%-28%, P = 0.31) higher for the preemptive group. No significant differences in blood count abnormalities or the incidence of sepsis and infections were observed other than CMV. In total, 19 patients(14.7%) received ganciclovir due to CMV viremia and/or infections. Patients who were treated according to the preemptive algorithm had a significantly higher rate risk of therapeutic intervention with ganciclovir [n = 16(23.5%) vs n = 3(4.9%), P = 0.003)].CONCLUSION: These data suggest that CMV prophylaxis is superior to a preemptive strategy in patients undergoing liver transplantation. | Philipp Simon Max Sasse Sven Laudi David Petroff Michael Bartels Udo X Kaisers Sven Bercker | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 2 | 紫杉醇诱导的胰腺癌SW1990细胞凋亡过程中转录激活因子5和Bax表达水平的变化显示文摘目的转录激活因子5(Activating transcription factor 5,ATF5)是一个新的与肿瘤细胞分化、增殖及凋亡密切相关的因子。文中检测胰腺癌SW1990细胞中ATF5的表达,并进一步研究紫杉醇(Paclitaxel,PTX)诱导的人胰腺癌SW1990细胞凋亡的水平,及其与ATF5、Bax表达水平的相关性。方法 RT-PCR检测未经药物处理的SW1990细胞中ATF5 mRNA表达水平;以不同浓度的紫杉醇(0、6.25、12.5、25、50、100、200 nmol/L)作用SW1990细胞不同时间(0、6、12、24、48 h),噻唑蓝(MTT)比色法检测细胞增殖情况;用100 nmol/L紫杉醇作用SW1990细胞不同时间(0、12、24、48 h)后,观察形态学变化并用Annexin V/7-AAD双染法,流式细胞仪检测细胞凋亡情况;采用RT-PCR检测紫杉醇作用不同时间后ATF5、Bax的mRNA表达变化。结果胰腺癌SW1990细胞中表达ATF5。紫杉醇抑制胰腺癌SW1990细胞的增殖,并在一定范围内呈剂量、时间相关性。随着紫杉醇作用时间的增加,流式细胞仪检测凋亡率显著提高。半定量RT-PCR检测结果显示:ATF5、Bax mRNA表达均明显增强,且两者之间存在相关性(r=0.916,P<0.05)。结论 ATF5在胰腺癌SW1990细胞中高表达,并且在紫杉醇诱导的细胞凋亡过程中,表达量进一步上升,其变化趋势与Bax基因相似。提示ATF5参与紫杉醇诱导的细胞凋亡,并可能与Bax的凋亡途径存在相关性。 | 胡明 钱冬萌 侯云 彭凯 李玲 宋旭霞 LIU David X 王斌 | 2010 | 医学研究生学报2010，23，11： | 3 |
| 3 | Efficacy and safety of percutaneous sacroplasty for painful osteoporotic sacral insufficiency fractures 显示文摘 | Michael E Depalma J David X | 2007 | Spine2007，32，15： | 1 |
| 4 | Enhancement of metal dispersion and selective acetylene hydrogenation catalytic properties of a supported Pd catalyst 显示文摘 | Feng J T Ma X Y David G E | 2011 | Industrial Engineering Chemical Research2011，50，4： | 1 |
| 5 | Transferred-substrate InP-based heterostructure barrier varactor diodes on quartz显示文摘 | Arscott S David T Melique X | 2000 | Microwave and Guided Wave Letters2000，10，11： | 1 |
| 6 | Growth of zinc blende MnS and MnS heterostructures by MBE using ZnS as a sulfur source显示文摘 | David L Bradford C Tang X | 2003 | J Cryst Growth2003，251，： | 1 |
| 7 | Foreign Direct Investment and Productivity Spillovers in the Chinese Manufacturing Sector 显示文摘 | LI X LIU X DAVID P | 2001 | Economic System2001，25，： | 1 |
| 8 | The relationship between therapy intensity and rehabilitative outcomes after traumatic brain injuey : a muhicenter analysis 显示文摘 | David X Cifu Jeffrey S | 2003 | Arch Phys Med Rehabil2003，84，10： | 1 |
| 9 | Reactive power optimisation with voltage stability consideration in power market显示文摘 | Lin X David A K Yu C W | 2003 | IEE Proceedings: Generation Transmission and Distribution2003，150，3： | 1 |
| 10 | FAST TCP:Motivation, archi- tecture,algorithms, performance显示文摘 | David X Wei Cheng Jin Low S H | 2006 | IEEE Trans on Networking2006，14，6： | 1 |
| 11 | A 640 × 512 CMOS image sensor with ultrawide dynamic range floating-point pixel-level ADC 显示文摘 | Yang David X D EI Gamal Abbas Fowler Boyd Tian Hui | 1999 | IEEE Journal of Solid-state Circuits1999，34，12： | 1 |
| 12 | Interdependence of oil prices and stock market indices: a copula approach显示文摘 | Kunlapath S Tatevik Z David L Wu X | 2014 | Energy Economies2014，44，4： | 1 |
| 13 | Tracking a financial Benchmark using a few assets显示文摘 | DAVID D Y ZHANG S Z ZHOU X Y | 2006 | Operations Research2006，54，2： | 1 |
| 14 | Modeling optimal grazing management for grassland eehabilitation on the typical steppe: A ease study in Taipusi Banner, Inner Mongolia, China 显示文摘 | Yang Z Zhu X David K | 2010 | The Philippine Agricultural Scientist2010，93，4： | 1 |
| 15 | Gene expression of osteoprotegerin lifand,osteoprotegefin, and receptor activator of NF - KB in giantcell tumor of bone 显示文摘 | Lin H Jiake X David JW | 2000 | American J Pathology2000，156，： | 1 |
| 16 | Precipitation variability (1956-2002) in the Dongjiang River (Zhujiang River basin, China) and associated large-scale circulation显示文摘 | David C Y Q Zhang Q Lu X X | 2011 | Quaternary International2011，244，： | 1 |
| 17 | Biofuels and synthetic fuels in the US and China: A review of Well-to-Wheel energy use and greenhouse gas emissions with the impact of land-use change显示文摘 | Yah X Y Oliver R David A | 2010 | Energy & Environ- mental Science2010，3，2： | 1 |
| 18 | Occupational lung disease in China显示文摘 | wang X R David C C | 2003 | Int J Occup Environ Health2003，9，： | 1 |
| 19 | Microwave Assisted Catalytic Reduclion of Sulfur Dioxide with Methane Over MoS2 Catalysts显示文摘 | Zhang X L David O H Colleen L | 2001 | Applied Catalysis B: Envlmnrnontal2001，33，2： | 1 |
| 20 | Synthesis of SnO2 hierarchical structures assembled from nanosheets and their lithium storage properties 显示文摘 | Wu H B Chen J S Lou (David) X W | 2011 | J Phys Chem C2011，115，24： | 1 |
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