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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 3 | An economic dispatch model incorporating wind power显示文摘 | John H David C Y Kalu B | 2008 | IEEE Transactions on Energy conversion2008，32，2： | 1 |
| 4 | The Efficiency of the National Elec- tricity Board in Malaysia:An Intercountry Comparison Using DEA 显示文摘 | Jamaluddin M Y David H | 1997 | Energy Economics1997，，19： | 1 |
| 5 | Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses显示文摘 | Xu Y H Gao S David K C | 2004 | Biochemical and Biophysical Research Communications2004，315，3： | 1 |
| 6 | High-pressure methane and carbon dioxide adsorption on dry and moisture-equilibrated Pennsylvanian coals显示文摘 | Krooss B M van Bergen F Gensterblum Y Siemons N Pagnier H J M David P | 2002 | Int J Coal Geol2002，51，2： | 1 |
| 7 | Bayesian network model for reliability assessment of power systems 显示文摘 | David C Y Thanh C N Peter H | 1999 | IEEE Trans on Power Systems1999，14，2： | 1 |
| 8 | Ultrastructure of vitellogenesis incestode(Moniezia expansa)(Cestoda:Cyclophllidea)显示文摘 | LI H Y GERARD P B DAVID W H | 2003 | Acta ZoologicalSinica2003，49，2： | 1 |
| 9 | Transient stability enhancement and regulation of power systems 显示文摘 | WANG Y DAVID J Hill RICHARD H Middletor | 1993 | IEEE Trans on Power Systems1993，8，2： | 1 |
| 10 | Study on frequency and predictors of dementia after ischemic stroke: The Chongqing Stroke Study显示文摘 | David H Zhou D John Y | 2004 | J Neurol2004，251，： | 1 |
| 11 | Femtosecond laser induced ablation of crystalline silicon upon double beam irradiation显示文摘 | Tae Y C David J H Costas P G | 2002 | Appl Surf Sci2002，，： | 1 |
| 12 | Direct torque control of brushless DC drives with reduced torque ripple 显示文摘 | Liu Y Zhu Z Q David H | 2005 | IEEE Transactions on Industry Applications2005，41，2： | 1 |
| 13 | Spermatogenesis,spermatogenesisand spermatozoon in the cestode(Moniezia expansa)(Cyclophllidea,Ano-plocephalidae)显示文摘 | LI H Y GERARD P B DAVID W H | 2003 | Acta Zoological Sinica2003，49，3： | 1 |
| 14 | Frequency and risk factor of vascular cognitive impairment three months after ischemic stroke in china:the Chongqing stroke study显示文摘 | David H Zhou D John Y | 2005 | Neuroepidemiology2005，24，： | 1 |
| 15 | The role of solute in grain refinement of magnesium显示文摘 | Lee Y C Dahle A K David H S | 2000 | Metallurgical and Materials Transactions A2000，31，11： | 1 |
| 16 | Design optimization of short stroke single phase tubular permanent magnet motor for refrigeration applications 显示文摘 | WANG J B DAVID H LIN Z Y | 2010 | IEEE Transactions on In- dustry Electronic2010，57，1： | 1 |
| 17 | Comparison of methods to detect biosurfactant production by diverse microorganisms显示文摘 | Noha H Y Kathleen E D David P N | 2004 | Journal of Microbiological Methods2004，56，： | 1 |
| 18 | Ontology-based assembly design and information sharing for collaborative product development 显示文摘 | KIM K Y DAVID G M YANG H | 2006 | Computer Aided Design2006，38，12： | 1 |
| 19 | An economic dispatch model incorporating wind power显示文摘 | JOHN H DAVID C Y KALU B | | 0，，02： | 1 |
| 20 | Thermophoretic deposition of aerosol particles in turbulent pipe flow显示文摘 | Romay Francisco J Takagaki Sho S David Y Pui H and Benjamin Liu Y H | 1998 | Journal of Aerosol Science1998，29，8： | 1 |
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