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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 3 | RNA polymerase Ⅲ transcribes human microRNAs显示文摘 | Lanier W Davidson B L | 2006 | Nat Struct Mol Biol2006，13，12： | 1 |
| 4 | Microbial biomass as a source of ni-trogen for cereal 显示文摘 | Lthbridge G Davidson M S | 1983 | Soil Biology and Biochemistry1983，15，： | 1 |
| 5 | Nitrogen leac- hing in Berrndagrass turf显示文摘 | Synder G H Burt E O Davidson J M | 1981 | Turfgrass Society1981，107，： | 1 |
| 6 | A chirp scaling approach for processing squint mode SAR data 显示文摘 | Davidson G W Cumming I G Ito M R | 1996 | IEEE Trans on Aerospace and Electronic Systems1996，32，1： | 1 |
| 7 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Turpie A G Lassen M R Davidson B L | 2009 | Lancet2009，373，9676： | 1 |
| 8 | Diagnosis and treatment of familial hypercholesterolaemia 显示文摘 | Hovingh G K Davidson M H Kastelein J J P | 2013 | European heart journal2013，34，13： | 1 |
| 9 | Advances in fluorescent protein technology显示文摘 | Shaner N C Patterson G H Davidson M W | 2007 | J Cell Sci2007，120，24： | 1 |
| 10 | Wavelet packet division multiplexing and wavelet packet design under timing error effects显示文摘 | Won G K M Wu J Davidson N N | 1997 | IEEE Trans Signal Processing1997，45，12： | 1 |
| 11 | Training effects in mice after long-term voluntary exercise显示文摘 | DAVIDSON S R BURNETT M LAURIE H G | 2006 | Med Sci Sports Exe2006，38，2： | 1 |
| 12 | Immunomodulatory activities of small host defense peptides显示文摘 | Bowdish D M Davidson D J Scott M G | 2005 | Antimicrob Agents Chemother2005，49，： | 1 |
| 13 | Missing sinks, feedbacks,and understanding the role of terrestrial ecosystems in the global carbon balance显示文摘 | Houghton R A Davidson E A Woodwell G M | 1998 | Global Biogeochemical Cycles1998，，12： | 1 |
| 14 | Surface roughness prediction of flow-formed AA6061 alloy by design of experiment 显示文摘 | Davidson M J Balasubramanianb K Tagore G R N | 2008 | Journal of Materials Processing Technolo- gy2008，202，123： | 1 |
| 15 | A Chirp Scaling Approach for Processing Squint Mode SAR Data显示文摘 | Davidson G W Cumming I G Ito M R | 1996 | IEEE Trans on AES1996，32，1： | 1 |
| 16 | Missing Sinks, Feedbacks and Understanding the Role of Terrestrial Ecosystems in the Global Carbon Balance 显示文摘 | Houghton R A E A Davidson and G M Woodwell | 1998 | Global Biogeochem Cycles1998，，12： | 1 |
| 17 | Sol-gel derived coatings on glass显示文摘 | D R Uhlmann T Suratwala K Davidson J M Bouton G Teowee | 1997 | Journal of Noncrystalline Solids1997，218，： | 1 |
| 18 | A Chirp Scaling Approach for Processing Squint Mode SAR Data显示文摘 | Davidson G W Cumming I G Ito M R | 1996 | IEEE Trans on AES1996，32，1： | 1 |
| 19 | The human an- timierobial peptide LL - 37 is a multifunetional m,adulator of innate immune responses显示文摘 | SCOTT M G DAVIDSON D J GOLD M R | 2002 | J Immunol2002，169，7： | 1 |
| 20 | A Chirp Scaling Approach for Processing Squint Mode SAR Data显示文摘 | DAVIDSON G W CUMMING I G ITO M R | 1996 | IEEE Trans on Aerospace and Elec tronic Systems1996，32，1： | 1 |
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