|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effectiveness of probiotics in irritable bowel syndrome:Updated systematic review with meta-analysis显示文摘AIM:To investigate the efficacy of probiotics in irritable bowel syndrome(IBS) patients.METHODS:Pub Med,Cochrane library,Scopus,Google Scholar,and Clinicaltrial.gov databases were searched for literature published between September 2007 and December 2013.The applied Mesh terms were 'probiotics,' 'irritable bowel syndrome,' and 'irritable bowel syndrome treatment.' The collected data contained24 clinical trials,of which 15 were eligible for meta-analysis and nine were reviewed systematically.All studies were randomized placebo-controlled trials in patients with IBS that investigated the efficacy of probiotics in IBS improvement.The Jadad score was used to assess the methodological quality of trials.The quality scale ranges from 0 to 5 points,with a score ≤ 2 indicating a low quality report,and a score of ≥3 indicating a high quality report.Relative risk(RR),standardized effect size,and 95%CI were calculated using the Der Simonian-Laird method.The Cochran Q test was used to test heterogeneity with P < 0.05.Funnel plots were constructed and Egger's and BeggMazumdar tests were performed to assess publication bias.RESULTS:A total of 1793 patients were included in the meta-analysis.The RR of responders to therapies based on abdominal pain score in IBS patients for two included trials comparing probiotics to placebo was 1.96(95%CI:1.14-3.36;P = 0.01).RR of responders to therapies based on a global symptom score in IBS patients for two included trials comparing probiotics with placebo was 2.43(95%CI:1.13-5.21;P = 0.02).For adequate improvement of general symptoms in IBS patients,the RR of seven included trials(six studies) comparing probiotics with placebo was 2.14(95%CI:1.08-4.26;P = 0.03).Distension,bloating,and flatulence were evaluated using an IBS severity scoring system in three trials(two studies) to compare the effect of probiotic therapy in IBS patients with placebo,the standardized effect size of mean differences for probiotics therapy was-2.57(95%CI:-13.05--7.92).CONCLUSION:Probiotics reduce pain and symptom severity scores.The results demonstrate the beneficial effects of probiotics in IBS patients in comparison with placebo. | Tina Didari Shilan Mozaffari Shekoufeh Nikfar Mohammad Abdollahi | 2015 | World Journal of Gastroenterology2015，21，10： | 51 |
| 2 | Calcium-Dependent Protein Kinase CPK21 Functions in Abiotic Stress Response in Arabidopsis thaliana显示文摘钙依赖者蛋白质 kinases (CDPK ) 包括察觉到领域和 kinase 受动器领域的钙在一个分子以内在被联合的植物 serine/threonine 蛋白质 kinases 的一个家庭。到目前为止,在不能生活的应力发信号的生物功能仅仅为很少 CDPK isoforms 被报导了,而为这些 CDPK 的内在的生物化学的机制主要仍然是未知的。这里,我们证明从 Arabidopsis thaliana 的 CPK21 生物化学地响应 hyperosmotic 应力在 vivo 被激活。cpk21 的 Loss-of-function 幼苗对 hyperosmotic 应力更容忍,变异的植物关于标记基因表示和代谢物累积显示出增加的压力回答。在互补在 cpk21 异种背景衬里的转基因的 Arabidopsis,在哪个任何一个 CPK21 野类型,或带氨基酸的替换的全身的酶变体稳定地被表示,压力 responsitivity 被 CPK21 然而并非与 kinase 恢复不活跃的变体。生物化学的描述在 planta,综合并且净化的 CPK21 蛋白质表明在钙绑定领域以内,与 C 终端 EF3 主题和 EF4 主题相比的 N 终端 EF1 主题和 EF2 主题在他们对调整钙的 kinase 活动的贡献不同,为 N 终端 EF 手对建议一个关键角色。我们的数据为在不能生活的应力发信号作出贡献的 CPK21 提供证据并且建议 N 终端 EF 手对是控制 CPK21 的特性的一个察觉到钙的决定因素函数。 | Sandra Franz Britta Ehlert Anja Liese Joachim Kurth Anne-Claire Cazale Tina Romeis | 2011 | Molecular Plant2011，4，1： | 27 |
| 3 | Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease显示文摘It has been presumed that aberrant immune response to intestinal microorganisms in genetically predisposed individuals may play a major role in the pathogenesis of the inflammatory bowel disease, and there is a good deal of evidence supporting this hypothesis. Commensal enteric bacteria probably play a central role in pathogenesis, providing continuous antigenic stimulation that causes chronic intestinal injury. A strong biologic rationale supports the use of probiotics and prebiotics for inflammatory bowel disease therapy. Many probiotic strains exhibit anti-inflammatory properties through their effects on different immune cells, proinflammatory cytokine secretion depression, and the induction of anti-inflammatory cytokines. There is very strong evidence supporting the use of multispecies probiotic VSL#3 for the prevention or recurrence of postoperative pouchitis in patients. For treatment of active ulcerative colitis, as well as for maintenance therapy, the clinical evidence of efficacy is strongest for VSL#3 and Escherichia coli Nissle 1917. Moreover, some prebiotics, such as germinated barley foodstuff, Psyllium or oligofructose-enriched inulin, might provide some benefit in patients with active ulcerative colitis or ulcerativecolitis in remission. The results of clinical trials in the treatment of active Crohn's disease or the maintenance of its remission with probiotics and prebiotics are disappointing and do not support their use in this disease. The only exception is weak evidence of advantageous use of Saccharomyces boulardii concomitantly with medical therapy in maintenance treatment. | Rok Orel Tina Kamhi Trop | 2014 | World Journal of Gastroenterology2014，20，33： | 27 |
| 4 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 5 | 社会化搜索研究进展综述显示文摘首先,引入互联网群体协作的思想,对社会化搜索的概念进行初步界定;随后,在宏观与微观两个层面上,重点从动因(why)、用户(who)、目标(what)、形式(how)4个维度对社会化搜索的概念进行深入解析,并分别从行为、技术、应用、资源4个视角对当前社会化搜索的主要研究内容和主题进行归纳,试图从理论上明晰社会化搜索今后的研究思路与方向;最后阐述当前社会化搜索的研究不足和发展趋势。 | 孙晓宁 朱庆华 赵宇翔 Jia Tina Du | 2014 | 图书情报工作2014，58，17： | 18 |
| 6 | 新西兰典型雨水管理政策剖析与启示显示文摘大力发展雨水利用事业,除技术支持以外,还需要完善的雨水利用制度和管理措施。介绍了新西兰雨水利用政策的整体框架及雨水管理政策,如雨水基础设施政策、私人地区雨水管理政策、雨水排放和处置政策、雨水灾害与地表径流政策、河流管理政策等。其次介绍了新西兰的雨水管理,主要包括洪水管理、河流管理、污染物管理等。在对新西兰雨水政策剖析的基础上,提出了对我国城市雨水管理的建议。 | 刘洋 李俊奇 刘红 孟光辉 Frank Tina | 2007 | 中国给水排水2007，23，20： | 18 |
| 7 | 乌苏酸联合吉西他滨对胰腺癌PANC-1细胞增殖和凋亡的影响显示文摘目的:探讨乌苏酸联合吉西他滨对胰腺癌PANC-1细胞增殖和凋亡的影响。方法:以乌苏酸、吉西他滨单独用药作用于体外培养的胰腺癌细胞PANC-1细胞,采用细MTT法检测细胞半抑制浓度(IC_(50)),确定药物给药浓度;以乌苏酸(2μmol/L)、吉西他滨(0.2μmol/L)单独及联合作用于PANC-1细胞,采用锥虫蓝染色法检测PANC-1细胞存活率,PI染色后PANC-1细胞中检测细胞凋亡,采用细胞划痕实验检测PANC-1细胞迁移和伤口愈合情况,采用Western blotting检测对照组、乌苏酸组与吉西他滨组单独及联合用药组细胞中P-JNK、Bcl-2、IL-6、P-Stat 3、NF-κB和Cox-2蛋白的表达。结果:乌苏酸和吉西他滨对胰腺癌PANC-1细胞均有较强的抑制作用,其IC_(50)分别是13.67和2.78μmol/L,据此选择它们的实验浓度分别为2和0.2μmol/L。两者联合用药比分别单独用药能更显著抑制癌细胞的增殖活性[(46.47±5.07)%vs(78.38±8.65)%、(76.12±3.23)%,均P<0.05],能更明显诱导癌细胞凋亡[(39.78±7.01)%vs(20.35±8.51)%、(20.35±8.51)%,均P<0.01]和抑制细胞迁移能力(P<0.01),同时更显著抑制凋亡相关蛋白Bcl-2、IL-6的表达及促进P-JNK的表达。结论:乌苏酸和吉西他滨协同增强抑制胰腺癌PANC-1细胞的增殖和迁移以及促凋亡作用,其机制可能与抑制Bcl-2、IL-6、P-Stat 3和促进P-JNK蛋白表达有关。 | 江森 郑希 何燕 Tina LIAO 张焜 | 2018 | 中国肿瘤生物治疗杂志2018，25，3： | 11 |
| 8 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 9 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 10 | Microscopic colitis: A review of etiology, treatment and refractory disease显示文摘Microscopic colitis is a common cause of chronic,nonbloody diarrhea. Microscopic colitis is more common in women than men and usually affects patients in their sixth and seventh decade. This article reviews the etiology and medical management of microscopic colitis. The etiology of microscopic colitis is unknown, but it is associated with autoimmune disorders, such as celiac disease, polyarthritis, and thyroid disorders. Smoking has been identified as a risk factor of mi-croscopic colitis. Exposure to medications, such as non-steroidal anti-inflammatory drugs, proton pump inhibitors, and selective serotonin reuptake inhibitors, is suspected to play a role in microscopic colitis, although their direct causal relationship has not been proven. Multiple medications, including corticosteroids, anti-diarrheals, cholestyramine, bismuth, 5-aminosalicylates, and immunomodulators, have been used to treat microscopic colitis with variable response rates. Budesonide is effective in inducing and maintaining clinical remission but relapse rate is as high as 82% when budesonide is discontinued. There is limited data on management of steroid-dependent microscopic colitis or refractory microscopic colitis. Immunomodulators seem to have low response rate 0%-56% for patients with refractory microscopic colitis. Response rate 66%-100% was observed for use of anti-tumor necrosis factor(TNF) therapy for refractory microscopic colitis. Anti-TNF and diverting ileostomy may be an option in severe or refractory microscopic colitis. | Tina Park David Cave Christopher Marshall | 2015 | World Journal of Gastroenterology2015，21，29： | 9 |
| 11 | 靶区和剂量控制下125Ⅰ粒子治疗颅内恶性肿瘤的再评价显示文摘目的再次评价靶区和剂量控制下125I粒子治疗颅内恶性肿瘤的疗效和并发症。方法回顾分析2003年11月—2016年5月青岛大学附属医院、山东省滕州市中心人民医院、山东省邹平中医院等12家医院310例颅内恶性肿瘤患者412次手术的临床资料,分析靶区和剂量控制下125I粒子治疗颅内恶性肿瘤的技术,评价疗效和并发症。对颅内恶性肿瘤进行分层研究,行靶区和剂量控制下125I粒子治疗。结果单发脑转移瘤、低级别胶质瘤、高级别胶质瘤、手术后复发、放疗后复发、其他(脑膜瘤、垂体瘤等)中位生存期分别是19、67、41、26、23、46个月;中位无进展生存时间分别是19、42、6、9、11、12个月。并发症种类多,发生率低,总并发症发生率10.4%;术后7~45 d死亡3例。结论靶区和剂量控制下125I粒子治疗颅内恶性肿瘤可以取得较好的疗效,而并发症较低,与外科切除、外放射治疗各具特点,应该进一步研究,并形成临床路径。 | 胡效坤 彭丽静 刘士锋 张开贤 刘院生 张福君 朱旭东 巩秀珍 高阳 王德峰 Tina Kapur 李子祥 | 2017 | 中华医学杂志2017，97，19： | 9 |
| 12 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 13 | Data Management Planning:How Requirements and Solutions are Beginning to Converge显示文摘Effective stewardship of data is a critical precursor to making data FAIR.The goal of this paper is to bring an overview of current state of the art of data management and data stewardship planning solutions(DMP).We begin by arguing why data management is an important vehicle supporting adoption and implementation of the FAIR principles,we describe the background,context and historical development,as well as major driving forces,being research initiatives and funders.Then we provide an overview of the current leading DMP tools in the form of a table presenting the key characteristics.Next,we elaborate on emerging common standards for DMPs,especially the topic of machine-actionable DMPs.As sound DMP is not only a precursor of FAIR data stewardship,but also an integral part of it,we discuss its positioning in the emerging FAIR tools ecosystem.Capacity building and training activities are an important ingredient in the whole effort.Although not being the primary goal of this paper,we touch also the topic of research workforce support,as tools can be just as much effective as their users are competent to use them properly.We conclude by discussing the relations of DMP to FAIR principles,as there are other important connections than just being a precursor. | Sarah Jones Robert Pergl Rob Hooft Tomasz Miksa Robert Samors Judit Ungvari Rowena I.Davis Tina Lee | 2020 | Data Intelligence2020，2，1： | 7 |
| 14 | Efficient first-principles prediction of solid stability:Towards chemical accuracy显示文摘The question of material stability is of fundamental importance to any analysis of system properties in condensed matter physics and materials science.The ability to evaluate chemical stability,i.e.,whether a stoichiometry will persist in some chemical environment,and structure selection,i.e.what crystal structure a stoichiometry will adopt,is critical to the prediction of materials synthesis,reactivity and properties.Here,we demonstrate that density functional theory,with the recently developed strongly constrained and appropriately normed(SCAN)functional,has advanced to a point where both facets of the stability problem can be reliably and efficiently predicted for main group compounds,while transition metal compounds are improved but remain a challenge.SCAN therefore offers a robust model for a significant portion of the periodic table,presenting an opportunity for the development of novel materials and the study of fine phase transformations even in largely unexplored systems with little to no experimental data. | Yubo Zhang Daniil A.Kitchaev Julia Yang Tina Chen Stephen T.Dacek Rafael A.Sarmiento-Pérez Maguel A.L.Marques Haowei Peng Gerbrand Ceder John P.Perdew Jianwei Sun | 2018 | npj Computational Materials2018，，1： | 7 |
| 15 | 反蛋白石结构的g-C_(3)N_(4)可控合成及其优异的光催化产氢性能显示文摘日渐严重的能源短缺和环境失衡问题已经阻碍了人类社会的进一步和长远可持续发展。能够将太阳能转化为可储存化学能的半导体基光催化技术被广泛的理解为一种经济和清洁的解决方式,比如光催化分解水。虽然被认为是有前途的光催化剂,g-C_(3)N_(4)低的比表面积极大地限制了其光催化性能。大孔-介孔结构可以为物质的传输和光的充分利用提供有效通道,从而提高光催化反应效率。本文中,具有反蛋白石(IO)结构的g-C_(3)N_(4)合理地通过紧密堆积的SiO_(2)作为模板来制备得到。并且显示出超高比表面积(450.2 m~2·g^(-1)),表现出更好的光催化产氢速率(21.22μmol·h^(-1)),约为体相g-C_(3)N_(4) (3.65μmol·h^(-1))的六倍。相对于体相g-C_(3)N_(4),IO g-C_(3)N_(4)表现了更好的可见光吸收能力,这得益于3D多孔结构的多重光散射效应。同时,较低的荧光强度、更长的荧光寿命、更小的Nyquist半圆环和更强的光电流响应协同地抑制了光生载流子的复合,降低了界面电荷传输的电阻,促进了光生电子的形成。此外,氮空位的存在能够增强局部电子密度,氮气吸-脱附测试揭示了IO g-C_(3)N_(4)中存在丰富的中孔和大孔,高比表面积暴露更多的活性边界和催化中心。正如光学性质、电子顺磁共振和电化学表征结果所揭示的那样,那些有利因素,包括增强的光利用率、提高的光生电荷的分离、延长的荧光寿命都赋予具有反蛋白石结构的IO g-C_(3)N_(4)优越的光催化性能。这项工作为结构设计和光催化性能调制做出了重要贡献。 | 陈一文 李铃铃 徐全龙 Tina Düren 范佳杰 马德琨 | 2021 | 物理化学学报2021，37，6： | 7 |
| 16 | Shoot-Specific Down-Regulation of Protein Farnesyltransferase (α-Subunit) for Yield Protection against Drought in Canola显示文摘Canola (Brassica 马来麝 L.) 是在世界和它的种子收益上的最重要的 oilseed 庄稼之一,质量被干旱应力显著地影响。作为对水赤字的天生、适应的回答,陆地植物由植物激素 abscisic 酸(骆驼毛的织物) 的快速的生合成避免潜在的损坏,它触发有气孔的闭合减少 transpirational 水损失。调停骆驼毛的织物的有气孔的反应是一个剂量依赖者过程;因此,为完成干旱回避的一条遗传工程途径能是敏化警卫房间的应答到这荷尔蒙。最近的基因研究作为在警卫房间控制骆驼毛的织物敏感的一个关键否定管理者指出了蛋白质 farnesyltransferase。我们以前证明了编码 farnesyltransferase (ERA1 ) 的 Arabidopsis 子单元的基因的下面规定提高植物的敏感到骆驼毛的织物和干旱忍耐。尽管 farnesyltransferase (AtFTA ) 的子单元也在骆驼毛的织物察觉到被含有,使用如此的一个基因目标在庄稼植物改进干旱忍耐的有效性没被验证。这里,我们报导 Arabidopsis hydroxypyruvate reductase (AtHPR1 ) 的倡导者的鉴定和描述,它在射击并且不在象根那样的非光合的纸巾明确地表示。AtHPR1 的倡导者区域包含元素和我们证实了的很好描绘的脱水应答的行动 cis 的核心主题那 AtHPR1 表情由干旱应力是可诱导的。在用驾驶 RNAi 构造的 AtHPR1 倡导者的 canola 的 FTA 的有条件、特定的下面规定在这块地里对干旱应力导致了收益保护。用这分子的策略,我们在在这重要庄稼种设计干旱忍耐取得了重要进步。 | Yang Wang Michelle Beaith Maryse Chalifoux Jifeng Ying Tina Uchacz Carlene Sarvas Rebecca Griffiths Monika Kuzma Jiangxin Wan Yafan Huang | 2009 | Molecular Plant2009，2，1： | 7 |
| 17 | 浅谈中式实木软体沙发设计显示文摘沙发作为客厅中必不可少的家具配置,在人们的生活中起到了越来越重要的作用,中式风格的沙发在日常生活中越来越普遍。本文通过对中式沙发的起源,及中式沙发的类型、设计进行了介绍,指出中式沙发顺应了当前重视文化的时代背景和现代的生活方式,弘扬了中国传统文化和民族特色。 | Tina | 2014 | 家具与室内装饰2014，21，9： | 6 |
| 18 | DNA杂交鉴定血吸虫种株的研究显示文摘曼氏血吸虫及日本血吸虫成虫基因组DNA经内切酶BglII、BamHI、XbaI、或EcoRI消化后,与^(32)P标记的pSM889探针杂交,或经EcoRI消化后与pSM389探针杂交。上述两种情况下的杂交带型在两种血吸虫之间均有明显区别。日本血吸虫湖北、湖南、江西、浙江及云南隔离群成虫基因组DNA经EcoRI消化后与探针pSM389的杂交带型显示各隔离群间主带相同,而次要带则有不同程度的区别。其中湖南、湖北及浙江隔离群的次要带型互相接近,而江西及云南隔离群的次要带型与前3个隔离群有明显区别,它们二者之间亦显著不同。本工作表明非主要杂交带型可作为日本血吸虫种下分类的依据。 | 曾宪芳 David Rollinson Tina K Walker 易新元 | 1993 | 中国寄生虫学与寄生虫病杂志1993，11，1： | 6 |
| 19 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 20 | 运用卫星数据和来自国家森林清查的野外数据进行全国森林变量估计显示文摘瑞典约有55%的土地面积被森林所覆盖。目前,瑞典的森林覆盖没有统一的和地理学上明晰的描述。现存的独立性数据源是Landsat TM和SPOT HRV卫星数据、地图蒙片(map mask)和森林清查样地。它们在一起,使森林变量(如材积和林分年龄)的计算机估计成为可能。这些估计的精确度在像素水平上是低的,但在林分水平上较高。在规划木材资源应如何加以利用或出于监测目的时,这类基于栅格的森林数据对政府来说是有帮助的。本文描述了以有效成本建立森林变量估计全国数据库的生成流程。我们在林分水平上评价了瑞典西南部某地森林变量估计的精确度。结果表明,总材积估计的整体均方根误差为33%,年龄估计的整体均方根误差为23%。 | Heather Reese Mats Nilsson Tina Granqvist Pahlén Olle Hagner Steve Joyce Ulf Tingelf Mikael Egberth Hkan Olsson 王胜 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员