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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Risk factor management and depression post-stroke: The value of an integrated model of care显示文摘 | Jacques Joubert Chris Reid Lynette Joubert David Barton Denise Ruth David Jackson John O’. Sullivan Stephen M. Davis | 2005 | Journal of Clinical Neuroscience2005，，1： | 2 |
| 3 | C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study显示文摘 | Sohail Q. Khan Onkar S. Dhillon Russell J. O’Brien Joachim Struck Paulene A. Quinn Nils G. Morgenthaler Iain B. Squire Joan E. Davies Andreas Bergmann Leong L. Ng | 2007 | Circulation2007，，16： | 2 |
| 4 | Stress hormone and blood glucose response follow acute stroke in the elderly显示文摘 | O Neill PA Davies I Fullerton K J | 1991 | Stroke1991，22，7： | 2 |
| 5 | Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database显示文摘 | Jacqueline A. Crosby MD Charles N. Catton MD Aileen Davis PhD Jean Couture MD Brian O'Sullivan MD Rita Kandel MD Carol J. Swallow MD PhD | 2001 | Annals of Surgical Oncology2001，，1： | 2 |
| 6 | The Preparation and Characterization of Poly(lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation Technique显示文摘 | Hayley Jeffery Stanley S. Davis Derek T. O’Hagan | 1993 | Pharmaceutical Research1993，，3： | 2 |
| 7 | Bose-Einstein condensation in a gas of sodium atoms显示文摘 | DAVIES K B MEWES M O ANDERSON M R | 1995 | Phys Rev Lett1995，75，22： | 2 |
| 8 | Impact of Premorbid Undernutrition on Outcome in Stroke Patients显示文摘 | James P. Davis Andrew A. Wong Philip J. Schluter Robert D. Henderson John D. O’Sullivan Stephen J. Read | 2004 | Stroke: Journal of the American Heart Association2004，，8： | 2 |
| 9 | Quantitativemonitoring of gene expression patterns with a complementary DNA microarray显示文摘 | Schena M Shalon D Davis R W Brown P O | 1995 | Science1995，270，： | 1 |
| 10 | Proton shock acceleration in laser-plasma interactions显示文摘 | Silva L O Marti M Davies J R | 2004 | Phys Rev Lett2004，92，01： | 1 |
| 11 | Taylor-Vaisey A:Impact of formal continuing medical education-Do conferences,work shops,rounds,and other traditional continuing education activities change physician behavior or health care outcomes?显示文摘 | Davis D O'Brien MAT Fseemantle N | 1999 | Jama-Joumal of the American Medical Association1999，282，9： | 1 |
| 12 | The Nature and Biosynthesis of the Carotenoids of Different Color Varieties of Capsicum annuum显示文摘 | B H Davies S Matthew J T O Kirk | 1970 | Phytochemistry1970，，9： | 1 |
| 13 | DNA methylation, cancer susceptibility, and nutrient interactions 显示文摘 | DAVIS C D UTHUS E O | 2004 | Experimental Biology and Medicine2004，229，10： | 1 |
| 14 | The Effects of Enhanced Milieu Teaching and a Voice Output Communication Aid on the Requesting of Three Children with Autism显示文摘 | Melissa L. Olive Berenice Cruz Tonya N. Davis Jeffrey M. Chan Russell B. Lang Mark F. O’Reilly Sarah M. Dickson | 2007 | Journal of Autism and Developmental Disorders2007，，8： | 1 |
| 15 | Work stress and well-being in the hotel industry显示文摘 | O' Neill J W Davis K | 2011 | International Journal of Hospitality Management2011，30，： | 1 |
| 16 | Functional movement screening: Predicting injuries in officer candi- dates 显示文摘 | O' Connor FG Deuster PA Davis J | 2011 | Medicine & Science in Sports & Exercise2011，43，12： | 1 |
| 17 | The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change显示文摘 | J.M. O’Neil T.W. Davis M.A. Burford C.J. Gobler | 2011 | Harmful Algae2011，，： | 1 |
| 18 | Genistein induces radioprotection by hematopoietic stem cell quiescence 显示文摘 | Davis TA Mungunsukh O Zins S | 2005 | Int J Radiat Biol2005，84，9： | 1 |
| 19 | Chemoprevention of aflatoxin B1 induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seeds显示文摘 | Farombi E O Adepoju B F Ola Davies O E | 2005 | Eur J Cancer Prey2005，14，3： | 1 |
| 20 | Hyperspectral remote sensing technology(HRST) program and the Naval Earth Map Observer (NEM) satellite 显示文摘 | WILSON T H DAVIS C O | 1998 | SPIE1998，3437，： | 1 |
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