| 1 | C-Glycoside Synthesis Enabled by Nickel Catalysis显示文摘Comprehensive Summary,C-Glycosides are critical,naturally occurring products and medicinal candidates,and extensive efforts have been made to explore efficient approaches for creating C-glycosidic bonds.Transition-metal-catalysis,particularly nickel-catalyzed C-glycosylation reactions constitute a promising strategy.However,achieving a stereoselective synthesis ofα-andβ-C-glycosides has been a long-standing challenge.To address this problem,a variety of nickel-mediated strategies have been developed.This review highlights recent developments in the nickel-catalyzed diastereoselective C-glycosylation reactions and briefly summarizes the mechanistic understandings of these methods. | Weidong Shang Rong Shi Dawen Niu | 2023 | Chinese Journal of Chemistry2023，41，17： | 1 |
| 2 | Structural and functional insights into sorting nexin 5/6 interaction with bacterial effector IncE显示文摘The endosomal trafficking pathways are essential for many cellular activities.They are also important targets by many intracellular pathogens.Key regulators of the endosomal trafficking include the retromer complex and sorting nexins(SNXs).Chlamydia trachomatis effector protein IncE directly targets the retromer components SNX5 and SNX6 and suppresses retromer-mediated transport,but the exact mechanism has remained unclear.We present the crystal structure of the PX domain of SNX5 in complex with IncE,showing that IncE binds to a highly conserved hydrophobic groove of SNX5.The unique helical hairpin of SNX5/6 is essential for binding,explaining the specificity of SNX5/6 for IncE.The SNX5/6–IncE interaction is required for cellular localization of IncE and its inhibitory function.Mechanistically,IncE inhibits the association of CI-MPR cargo with retromer-containing endosomal subdomains.Our study provides new insights into the regulation of retromer-mediated transport and illustrates the intricate competition between host and pathogens in controlling cellular trafficking. | Qingxiang Sun Xin Yong Xiaodong Sun Fan Yang Zhonghua Dai Yanqiu Gong Liming Zhou Xia Zhang Dawen Niu Lunzhi Dai Jia-Jia Liu Da Jia | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 1 |
| 3 | Response of water-use efficiency to phenology in the natural forest and grassland of the Loess Plateau in China显示文摘Ecosystem water use efficiency(WUE)is an integrated physiological metric for the coupling cycle between terrestrial carbon,water,and energy.How WUE responds to vegetation phenology(e.g.,SOS,EOS-start,end of growing season,and GSL-growing season length)shifting in temperate semi-arid regions is a hot spot in relative research fields.Based on remotesensing products and in-situ measured climate data,this study discussed how gross primary productivity(GPP),evapotranspiration(ET),and WUE(quantified by GPP/ET)would change with the altering vegetation phenology and climate in the untouched semi-arid forests and grasslands of the Chinese Loess Plateau during 2001–2020.Our results show that vegetation tended to green-up earlier and brown-down later from 2001 to 2020,causing an extended GSL.The forests had an earlier SOS,later EOS,and longer GSL than the grasslands,but the latter had a bigger variation amplitude.The WUE in the study area decreased significantly during spring and summer,while the grassland WUE increased in autumn;the annual mean reduction rate in grassland WUE was approximately twice that of woodland.Earlier SOS could increase forest WUE but reduce grassland WUE in spring,mainly because leaf unfolding has a more pronounced limitation on soil evaporation beneath the forest canopy.EOS had less impact on WUE,and no apparent difference existed between these two ecosystems.Climate change could affect WUE directly by changing GPP and ET and indirectly by regulating vegetation phenology.Warming can increase GPP and ET,causing an earlier SOS,further promoting GPP and ET(except forest ET).Precipitation significantly affected forest GPP and ET in spring,grassland GPP and ET in summer,and grassland ET in autumn;precipitation affects spring grassland WUE mainly via regulating SOS.Enhanced solar radiation could suppress grassland GPP in spring,promote forest ET in autumn,and regulate grassland WUE by affecting phenology.This study is meaningful for improving the process-based vegetation model and studying arid and semi-arid ecosystems’responses to a changing climate. | Xingyan TAN Yangwen JIA Cunwen NIU Dawen YANG Wen LU Chunfeng HAO | 2023 | Science China Earth Sciences2023，66，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员