| 1 | In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15显示文摘Dear Editor,As an emerging drug discovery paradigm,Proteolysis targeting chimeras(PROTACs)facilitate ubiquitination and degradation of the targets by cellular endogenous proteasome system.Compared with traditional small molecular inhibitors,PROTACs work like enzymes and can operate with or without functional inhibition of the targets,which endows this strategy to degrade drug targets,especially useful for“undruggable”ones. | Liang Li Dazhao Mi Haixiang Pei Qiuhui Duan Xinyue Wang Wenbo Zhou Jianping Jin Dali Li Mingyao Liu Yihua Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
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