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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Development of vascularendothelial growth factor receptor (VEGFR) kinase inhibitors asantiangiogenic agents in cancer therapy显示文摘 | Underiner TL Ruggeri B Gingrich DE | 2004 | Curr Med Chem2004，11，6： | 1 |
| 3 | Regulatory role of p27kip1 in the mouse and human testis显示文摘 | Beumer TL Kiyokawa H Roepers-Gajadien HL van den Bos LA Lock TM Gademan IS Rutgers DH Koff A de Rooij DG | | 0，，： | 1 |
| 4 | The molecular pathogenesis of prostate cancer:implications for prostate cancer prevention显示文摘 | Nelson WG De Marzo AM Deweese TL | 2001 | Urology2001，57，4： | 1 |
| 5 | Using remote photography in wildlife ecology: a review显示文摘 | Cutler TL Swann DE | 1999 | Wildlife Soc Bull1999，27，： | 1 |
| 6 | Panel discussion:cosmetic surgery of the buttocks region显示文摘 | Roberts TL De La Pena JA Toledo LS | 2003 | Aesthetic Surg J2003，23，5： | 1 |
| 7 | Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice显示文摘 | Barton DE Yang-feng TL Mason AJ | 1989 | Genomics1989，5，1： | 1 |
| 8 | Sitagliptin more effec- tively achieves a composite endpoint for A1C reduction, lack of hypogly- cemia and no body weight gain compared with glipizide 显示文摘 | Seek TL Engel SS Williams-Herman DE | 2011 | Diabetes Res Clin Pract2011，93，1： | 1 |
| 9 | Current uses of isolated limb perfusion in the clinic and a model system for new strategies显示文摘 | Eggermont AM de Wil JH ten Hagen TL | 2003 | Lancet Oncol2003，4，： | 1 |
| 10 | Preneoplastic prostate lesions: an opportunity for prostate cancer prevention 显示文摘 | Nelson WG De Matzo AM Deweese TL | 2001 | Ann N Y Acad Sci2001，952，： | 1 |
| 11 | Complications ofendotracheal intubation in the critically ill 显示文摘 | Griesdale DE Bosma TL Kurth T | 2008 | IntensiveCare Med2008，34，10： | 1 |
| 12 | Current uses of iso- lated limb perfusion in the clinic and a model system for new strategies显示文摘 | Eggermont AM de Wilt JH ten Hagen TL | 2003 | Lancet Oncol2003，4，7： | 1 |
| 13 | Minimal extracorpo- real circulation (MECC) does riot result in less hypertrophic scar formation as compared to conventional extracorporeal circulation (CECC) with dexamethasone 显示文摘 | Soykan EA Butzelaar L de Kroon TL | 2014 | Perfusion2014，29，3： | 1 |
| 14 | Preneoplastic prostate lesions:an opportunity for prostate cancer prevention 显示文摘 | Nelson WG De Marzo AM Deweese TL | 2001 | Ann NY Acad Sci2001，952，： | 1 |
| 15 | Current uses of isolated limgb perfusion in the clinic and a model system for new strategies显示文摘 | Eggeront AM de Wil JH ten Hagen TL | 2003 | Lancet Oncol2003，4，： | 1 |
| 16 | Capacitance effects 显示文摘 | De Levie tL On porous electrodes in electrolyte solutions: I | 1963 | Electrochim Acta1963，8，10： | 1 |
| 17 | Complicat! ons and consequences of endotracheal intubation and tracheotomy显示文摘 | Olson DE Petty TL | 1981 | Am J Med1981，70，1： | 1 |
| 18 | Nateglinide therapy for type 2 diabetes mellitus显示文摘 | Levien TL Baker DE Campbell RK | 2001 | Ann Pharmacother2001，35，11： | 1 |
| 19 | Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease显示文摘 | De Calignon A Spires-Jones TL Hyman BT | 2010 | Med Sci (Paris)2010，26，10： | 1 |
| 20 | Relationship between total bilirubin and endothelial function, inflammation and oxidative stress in HIV ‐infected adults on stable antiretroviral therapy显示文摘 | CO Hileman CT Longenecker TL Carman GL Milne DE Labbato NJ Storer CA White GA McComsey | 2012 | HIV Med2012，，10： | 1 |
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