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199篇 您的检索式：作者名="Dean L A"

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	题名	作者	年代	出处	被引量
1	Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells显示文摘Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system.	Benita L McVicker Dean J Tuma Carol A Casey	2007	World Journal of Gastroenterology2007，13，37：	2
2	p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘	Dean J L Brook M Clark A R	1999	J Biol Chen1999，274，：	1
3	Web search for a planet: The Google cluster architecture显示文摘	Barroso L A Dean J Holzle U	2003	IEEE Micro2003，23，2：	1
4	Geochemical and climatic effects of increased marine organic carbon burial at the Cenomanian/Turonian boundary显示文摘	ARTHUR M A DEAN W PRATT L M	1988	Nature1988，335，：	1
5	Altered imprinted gene methylation and expression in completely ES cell derived mouse fetuses: association with aberrant phenotypes 显示文摘	Dean W Bowden L Aitchison A	1998	Development1998，125，12：	1
6	Removing heavy metals from waste water 显示文摘	Dean J G Bosqui F L Bermond A	1972	Environ Sci Technol1972，6，6：	1
7	Age related differences in behavior across the life span of the C57BL/6J mouse显示文摘	Dean R L Scozafava J Goas J A	1981	Exp Aging Res1981，7，：	1
8	Web search for a planet: the googlecluster architecture 显示文摘	Barroso L A Dean J Holzle U	2003	IEEE Micro2003，232，：	1
9	Removing heavy metals from waste water显示文摘	Dean J G Bosqui F L Bermond A	1972	Environ Sci Technol1972，6，6：	1
10	Modification of the coding sequence enhances plant expression of insect control protein genes显示文摘	Perlak F J Fuchs R L Dean D A	1991	Proc Natl Acad Sci USA1991，88，8：	1
11	Information needs, uncertainty, and anxiety in women who had a breast biopsy with benign outcome显示文摘	Deane K A Degner L F	1998	Cancer Nuts1998，21，2：	1
12	Web Search for a Planet: The Google Cluster Architecture 显示文摘	Barroso L A Dean J Holzle U	2003	IEEE Micro2003，23，2：	1
13	Modification of the coding sequence enhance plant expression of insect control protein genes显示文摘	Perlak F J Fuchs R L Dean D A	1991	Proc Natl Acad Sci USA1991，88，8：	1
14	Combined microautographic and histopathologic analysis of the fate of challenge Schistosoma rnansoni schistosomula in mice immunized with irradiated cercariae显示文摘	Kassim O O Dean D A Mangold B L	2002	Am J Trop Med Hyg2002，47，：	1
15	Di- versity in organizations: Where are we now and where are we going?显示文摘	Shore L M Chung-Herrera B G Dean M A	2009	Human Resource Management Re- view2009，19，2：	1
16	Modification of the coding sequences plant expressing of insect control protein genes 显示文摘	Perlak F J Fuchs R L Dean D A	1991	Proc Natl Acad Sci USA1991，88，：	1
17	RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response显示文摘	Ertel A Dean J L Rui H	2010	Cell Cycle2010，9，20：	1
18	Cell-specific nitrogen responses mediate developmental plasticity显示文摘	Gifford M L Dean A Gutierrez R A	2008	Proc Nail Acad Sci USA2008，105，2：	1
19	Cadmium accumulation by a Citrobacter sp显示文摘	Macaskie L E Dean A C R	1984	Journal of general microbiolo- gy1984，130，1：	1
20	Magnetic resonance imaging of cervical ectopic pregnancy in the second trimester显示文摘	Le T Poder L Deans A	2012	J Comput Assist Tomogr2012，36，24：	1

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