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| 1 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 2 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 3 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 4 | Human resource management, manufacturing strategy, and firm performance 显示文摘 | Youndt M A Snell S A Dean J W Lepak D P | 1996 | Academy of Management Journal1996，39，： | 1 |
| 5 | Condensation heat transfer within horizontal tubes显示文摘 | Akers W W Deans H A Crosser O K | 1959 | Chemical En- gineering Progress Symposium Series1959，55，29： | 1 |
| 6 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
| 7 | Epigenetie modification is central to genome reprogramming in somatic cell nuclear transfer显示文摘 | Lako M Dean W | 2006 | Stem Cells2006，24，4： | 1 |
| 8 | Screening for congenital adrenal hyperplasia:the Delfia Screening Test overestimates serum 17-hydroxyprogesterone in preterm infants显示文摘 | al Saedi S Dean H Dent W | 1996 | Pediatrics1996，97，1： | 1 |
| 9 | Integrated manufacturing and hu- man resource management: a human capital perspective 显示文摘 | Snell S A Dean J W | 1992 | Academy of Management Journal1992，35，： | 1 |
| 10 | The Adenylate Cyclase Gene MAC1of Magnaporthe grisea Controls Appressorium Formation and Other Aspects of Growth and Develoment 显示文摘 | CHOI W DEAN R A | 1997 | Plant Cell1997，9，11： | 1 |
| 11 | Nitro- gen-doped graphene and its application in electrochemical biosensing显示文摘 | WANG YING SHAOYUYAN MATSON DEAN W | 2010 | ACS Nano2010，4，4： | 1 |
| 12 | History of water- column anoxia in the Black Sea indicated by pyrite framboids size distributions显示文摘 | WILKIN R T ARTHUR M A DEAN W E | 1997 | Earth and Planetary Science Letters1997，148，34： | 1 |
| 13 | The interfacialheat transfer coeYcient in hot die forging of titaniumalloy显示文摘 | Hu Z M Brooks J W Dean T A | 1998 | Proceedings of the Institution of MechanicalEngineers Part C: Journal of Mechanical EngineeringScience1998，212，6： | 1 |
| 14 | Determination of earbonate and organic matter in calcareous sediments and sedimentary roeks by loss on ignition:ComParison with other methods 显示文摘 | DEAN W E | 1974 | Journal of Sedimentary Petrology1974，44，： | 1 |
| 15 | Determination of carbonate and organic matter in calcareous sediments and sedimentary rocks by loss on ignition:Comparison with other methods显示文摘 | DEAN W E Jr | 1974 | J Sed Petrol1974，44，： | 1 |
| 16 | Stress analysis of drillstring threaded connections using the finite element method显示文摘 | MACDONALD K A DEANS W F | 1995 | Engineering Failure Analysis1995，2，1： | 1 |
| 17 | Geochemical and climatic effects of increased marine organic carbon burial at the Cenomanian/Turonian boundary显示文摘 | ARTHUR M A DEAN W PRATT L M | 1988 | Nature1988，335，： | 1 |
| 18 | Altered imprinted gene methylation and expression in completely ES cell derived mouse fetuses: association with aberrant phenotypes 显示文摘 | Dean W Bowden L Aitchison A | 1998 | Development1998，125，12： | 1 |
| 19 | Characterization and reactivity of iron nanoparticlesprepared with added Cu, Pd, and Ni显示文摘 | DONALD R B DEAN W M JAMES E A | 2010 | Environmen-tal Science and Technology2010，44，： | 1 |
| 20 | The use of the splitHopkinson pressure bar techniques in high strain rate mate-rials testing显示文摘 | Al-Mousawi M M Reid S R Deans W F | 1997 | Proceedings of the Institution of MechanicalEngineers Part C:Journal of Mechanical Engineering Sci-ence1997，211，4： | 1 |
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