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| 1 | Stem cell therapy as an emerging paradigm for stroke ( STEPS) Ⅱ显示文摘Cell-based therapies represent a new therapeutic approach for stroke.In 2007,investigators from academia,industry leaders,and members of the National Institutes of Health crafted recommendations to facilitate the | Savitz SI Chopp M Deans R Carmichael ST Phinney D Wechsler L | 2011 | 中华神经外科疾病研究杂志2011，10，3： | 5 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘Acute pancreatitis is of one the most common gastroenterology-related indications for hospital admissions worldwide.With the widespread reliance on endoscopic retrograde cholangiopancreatography(ERCP)for the management of pancreaticobiliary conditions,post-ERCP pancreatitis(PEP)has come to represent an important etiology of acute pancreatitis.Despite many studies aiming to better understand the pathogenesis and prevention of this iatrogenic disorder,findings have been heterogeneous,and considerable variation in clinical practice exists.Herein,we review the literature regarding PEP with the goal to raise awareness of this entity,discuss recent data,and present evidence-based best practices.We believe this manuscript will be useful for gastrointestinal endoscopists as well as other specialists involved in the management of patients with PEP. | Simcha Weissman Mohamed Ahmed Matthew R Baniqued Dean Ehrlich James H Tabibian | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，6： | 2 |
| 4 | Low potential for climatic stress adaptation in a rainforest drosophila species显示文摘 | Hoffmann A A Hallas R J Dean J A | 2003 | Science2003，301，： | 2 |
| 5 | Posterior interosseous nerve localization within the proximal forearm-a patient normalized parameter显示文摘AIM To provide a 'patient-normalized' parameter in the proximal forearm. METHODS Sixty-three cadaveric upper extremities from thirty-five cadavers were studied. A muscle splitting approach was utilized to locate the posterior interosseous nerve(PIN) at the point where it emerges from beneath the supinator. The supinator was carefully incised to expose the midpoint length of the nerve as it passes into the forearm while preserving the associated fascial connections, thereby preserving the relationship of the nerve with the muscle. We measured the transepicondylar distance(TED), PIN distance in the forearm's neutral rotation position, pronation position, supination position, and the nerve width. Two individuals performed measurements using a digital caliper with inter-observer and intraobserver blinding. The results were analyzed with the Wilcoxon-Mann-Whitney test for paired samples. RESULTS In pronation, the PIN was within two confidence intervals of 1.0 TED in 95% of cases(range 0.7-1.3 TED); in neutral, within two confidence intervals of 0.84 TED in 95% of cases(range 0.5-1.1 TED); in supination,within two confidence intervals of 0.72 TED in 95% of cases(range 0.5-0.9 TED). The mean PIN distance from the lateral epicondyle was 100% of TED in a pronated forearm, 84% in neutral, and 72% in supination. Predictive accuracy was highest in supination; in all cases the majority of specimens(90.47%-95.23%) are within 2 cm of the forearm position-specific percentage of TED. When comparing right to left sides for TEDs with the signed Wilcoxon-Mann-Whitney test for paired samples as well as a significance test(with normal distribution), the P-value was 0.0357(significance-0.05) indicating a significant difference between the two sides.CONCLUSION This 'patient normalized' parameter localizes the PIN crossing a line drawn between the lateral epicondyle and the radial styloid. Accurate PIN localization will aid in diagnosis, injections, and surgical approaches. | Srinath Kamineni Crystal R Norgren Evan M Davidson Ellora P Kamineni Andrew S Deane | 2017 | World Journal of Orthopedics2017，8，4： | 2 |
| 6 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 7 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 8 | In-vitro testing for assessing oral bioaccessibility of trace metals in soil and food samples显示文摘 | INTAWONGSE M DEAN J R | 2006 | Trends in Analytical Chemistry2006，25，9： | 1 |
| 9 | The Human ATP- Binding Cassette ( ABC ) Transporter Superfamily 显示文摘 | Dean M Rzhetsky A Allikmets R | 2001 | GENOME RESEARCH2001，11，7： | 1 |
| 10 | G Protein α Subunit Genes Control Growth, Development, and Pathogenicity of Magnaporthe grisea显示文摘 | LIU S H DEAN R A | 1997 | Mol Plant-Microbe Interact1997，10，9： | 1 |
| 11 | Neostigmine combined with bupivacaine, clonidine, and sufentanil for spinal labor analgesia显示文摘 | D'Angelo R Dean LS Meister GC | 2001 | Anesth Analg2001，93，6： | 1 |
| 12 | Extraction of Polyeyelie Aromatic Hydrocarbons from Highly Contaminated Soils Using Microwave Energy显示文摘 | Ramabas I J Dean J R | 1995 | Analyst1995，120，： | 1 |
| 13 | Mesenchymal stem cells: biology and potential clinical uses显示文摘 | Deans R J Moseley A B | 2000 | Exp Hematol2000，28，： | 1 |
| 14 | The dimen-sionality of the Maslach Burnout Inventory across small business owners and educators 显示文摘 | BOLES J S DEAN D H XAVIER J M R | 2000 | Journal of Vocational Behavior2000，，： | 1 |
| 15 | Boron nitride substrates for high-quality graphene electronics显示文摘 | Dean C R Young A F Meric I | 2010 | Nat Nnotechn2010，5，10： | 1 |
| 16 | The management of intrauterine synechiae显示文摘 | Thomson A J Abbott JA Deans R | 2009 | Curt Opin Obstet Gynecol2009，2，4： | 1 |
| 17 | A muhimodal RAGE-specific inhi- bitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease 显示文摘 | Deane R Singh I Sagare AP | 2012 | J Clin Invest2012，122，4： | 1 |
| 18 | Mesenchymal stem cell: Biology and potential clinical uses 显示文摘 | DEANS R J MOSELEY A B | 2008 | Exp Hematol2008，28，8： | 1 |
| 19 | Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of prote in kinase C-α expression显示文摘 | Mckay R Miraglia L | 1996 | Cancer Res1996，56，10： | 1 |
| 20 | The management of intrauterine synechiae 显示文摘 | Thomson AJ Abbott JA Deans R | 2009 | Curr Opin Obstet Gynecol2009，21，4： | 1 |
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