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| 1 | Endogenous rhythms in axial length and choroidal thickness in chicks:implications for ocular growth regulation显示文摘 | Debora L Christine F David T | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
| 2 | Autohydrolysis of Almond Shells for the Production of Xylo-oligosaccharides :Product Characteristics and Reaction Kinetics 显示文摘 | Debora N Xavier F Daniel M | 2005 | Ind Eng Chem Res2005，44，20： | 1 |
| 3 | Psyehosocial perspectives of the partners of breast cancer patients treated with a mastectomy显示文摘 | Luiza AK Debora S Aretuzza F | 2008 | Cancer Nursing2008，31，4： | 1 |
| 4 | Effects of acetate on the growth and fermentation performance of Escherichia coli KOll 显示文摘 | Takahashi Carohne M Takahashi Debora F Maria L C | 1999 | Applied Biochemistry and Bioteclmology1999，81，3： | 1 |
| 5 | S100B and NSE serum levels in patients with Parkinson's disease 显示文摘 | Debora VS Adriano BL Daniele F | 2005 | Parkinsonism and Re- lated Disorders2005，1，1： | 1 |
| 6 | The role of suprafacial oxygen in some perovskites for thecatalytic combustion of soot显示文摘 | DEBORA F NUNZIO R GUIDO S | 2003 | Journal of Catalysis2003，217，2： | 1 |
| 7 | Toxic Effect s of singlewalled carbon nanotubes in the development of E coli biofilm显示文摘 | Debora F Rodrigues Elimelech M | | 0，，12： | 1 |
| 8 | The ex utero intrapartum treatment( EXIT) pro-cedure for fetal head and neck masses 显示文摘 | Debora F Lourdes A | 2009 | AORN Journal2009，90，5： | 1 |
| 9 | Estrogenic activity removal of 17β-estradiol by ozonation and identification of by-products 显示文摘 | Danlele Bila Antonio F Montalveto Debora de A Azevedo | 2007 | Chemosphere2007，69，5： | 1 |
| 10 | Trypanocidal tetrahydrofuran lignans from Peperomia blanda 显示文摘 | Lidiane G F Debora C B Massuo J K | 2008 | Phytochemistry2008，69，： | 1 |
| 11 | Antibacteral effects of carbon nanombes: size does matter显示文摘 | Kang S Herznerg M Debora F | 2008 | Langmuir2008，24，： | 1 |
| 12 | Effects of acetate on the growth and fermentation performance of Escherichia coli kol 1显示文摘 | Takahashi Caroline M Takahashi Debora F Maria L C | 1999 | Applied Biochemistry and Biotechnology1999，81，： | 1 |
| 13 | Estrogenic activity removal of 17β-estradiol by ozonation and identification of by-products显示文摘 | Daniele Bila Antonio F Montalvao Debora de A | 2007 | Chemosphere2007，69，： | 1 |
| 14 | Maleated and non-maleated polyethylene-montmori-llonite layered silicate blown films: Creep, dispersionand crystallinity显示文摘 | AJIT R KASINATH N DEBORA F | 2005 | Polymer2005，46，8： | 1 |
| 15 | The role of suprafacial oxygen in some perovskites for the catalytic combustion of soot显示文摘 | DEBORA F NUNZIO R GUIDO S | 2003 | Journal of Catalysis2003，217，2： | 1 |
| 16 | The Role of Suprafacial Oxygen in Some Perovskites for the Catalytic Combustion of Soot显示文摘 | Debora F Nunzio R Guido S | 2003 | J Catal2003，217，2： | 1 |
| 17 | B-1 cells modulate the murine macrophage response to Leishmania major infection显示文摘AIM To investigate the modulatory effect of B-1 cells on murine peritoneal macrophages infected with Leishmania major(L. major) in vitro.METHODS Peritoneal macrophages obtained from BALB/c andBALB/c XID mice were infected with L. major and cultured in the presence or absence of B-1 cells obtained from wild-type BALB/c mice. Intracellular amastigotes were counted, and interleukin-10(IL-10) production was quantified in the cellular supernatants using an enzymelinked immunosorbent assay. The levels of the lipid mediator prostaglandin E2(PGE2) were determined using a PGE2 enzyme immunoassay kit(Cayman Chemical, Ann Arbor, MI), and the number of lipid bodies was quantified in the cytoplasm of infected macrophages in the presence and absence of B-1 cells. Culturing the cells with selective PGE2-neutralizing drugs inhibited PGE2 production and confirmed the role of this lipid mediator in IL-10 production. In contrast, we demonstrated that B-1 cells derived from IL-10 KO mice did not favor the intracellular growth of L. major.RESULTS We report that B-1 cells promote the growth of L. major amastigotes inside peritoneal murine macrophages. We demonstrated that the modulatory effect was independent of physical contact between the cells, suggesting that soluble factor(s) were released into the cultures. We demonstrated in our co-culture system that B-1 cells trigger IL-10 production by L. major-infected macrophages. Furthermore, the increased secretion of IL-10 was attributed to the presence of the lipid mediator PGE2 in supernatants of L. major-infected macrophages. The presence of B-1 cells also favors the production of lipid bodies by infected macrophages. In contrast, we failed to obtain the same effect on parasite replication inside L. major-infected macrophages when the B-1 cells were isolated from IL-10 knockout mice. CONCLUSION Our results show that elevated levels of PGE2 and IL-10 produced by B-1 cells increase L. major growth, as indicated by the number of parasites in cell cultures. | Angelica F Arcanjo Marise P Nunes Elias B Silva-Junior Monique Leandro Juliana Dutra Barbosa da Rocha Alexandre Morrot Debora Decote-Ricardo Celio Geraldo Freire-de-Lima | 2017 | World Journal of Biological Chemistry2017，8，2： | 0 |
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