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| 1 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 2 | Impact of eoleopteran- active Bt corn on non-target nematode communities in soil and decomposing corn roots显示文摘 | Deborah A N Agnes W N M Galen P D | 2014 | Soil Biology & Biochemistry2014，76，： | 1 |
| 3 | The Role of MITF Phosphorylation Sites During Coat Color and Eye Development in Mice Analyzed by Bacterial Artificial Chromosome Transgene Rescue显示文摘 | Bauer Georg L Praetorius Christian Bergsteinsdóttir Kristín Hallsson Jón H Gísladóttir Bryndís K Schepsky Alexander Swing Deborah A O’Sullivan T Norene Arnheiter Heinz Bismuth Keren Debbache Julien Fletcher Colin Warming S?ren Copeland Neal | 2009 | Genetics2009，，2： | 1 |
| 4 | Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia显示文摘 | Michael A Beardslee Deborah L Lerner Peter N Tadros James G Laing Eric C Beyer Kathryn A Yamada André G Kléber Richard B Schuessler Jeffrey E Saffitz | 2000 | Circulation Research: Journal of the American Heart Association2000，，： | 1 |
| 5 | Smart-grid security issues显示文摘 | Hadley M Lu N Deborah A | 2010 | IEEE Security and Privacy2010，8，1： | 1 |
| 6 | Transforming technological pioneering into competitive advantage 显示文摘 | ZAHRA S A SARAH N DEBORAH J B | 1995 | Academy of Management Executive1995，9，： | 1 |
| 7 | Framework for COPD forecasting in the UK using weather and climate change predictions显示文摘 | Deborah Hemming A Colman P James N Kaye P Marno D McNeall R McCarthy T Laing-Morton E Palin P Sachon C Sarran I Taylor | 2009 | IOP Conference Series: Earth and Environmental Science2009，，14： | 1 |
| 8 | Is treatment-associated hypomania rare with duloxetine: Secondary analysis of controlled trials in non-bipolar depression显示文摘 | David Dunner A Deborah N | 2005 | Journal of Affective Disorders2005，87，： | 1 |
| 9 | Is treatment-associated hypomania rare with duloxetine : Secondary analysis of controlled trials in non-bipolar depression 显示文摘 | David L Dunner A Deborah N | 2005 | Journal of Affective Disorders2005，87，： | 1 |
| 10 | Blood Gases and Retinopathy of Prematurity: The ELGAN Study显示文摘 | Hauspurg Alisse K Allred Elizabeth N Vanderveen Deborah K Chen Minghua Bednarek Francis J Cole Cynthia Ehrenkranz Richard A Leviton Alan Dammann Olaf | 2011 | Neonatology2011，，： | 1 |
| 11 | A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study显示文摘Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive disease.BCG induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor elimination.We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment biopsies.Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by immunohistochemistry.TME polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+eosinophils.In addition,PD-1/PD-L1 staining was quantified.The results correlated with BCG response.In most non-responders,Th1/Th2 markers were compared in pre-and post-BCG biopsies.ORR was 65.6%in the study population.BCG responders had a higher G/T ratio and a greater number of degranulated EPX+cells.Variables combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower specificity.Relapse-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of response.PD-L1/PD-1 expression was not associated with the response to BCG.Our results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity. | GUSTAVO MARTÍN VILLOLDO MARÍA TERESA POMBO MARIANA ARIS JOAQUÍN CHEMI PABLO MANDÓ SUPRIYA NAGARAJU JUAN CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA AMAT JOSÉLEÓN MELLADO JOSÉMORDOH ALBERTO VILLARONGA MARÍA MARCELA BARRIO | 2023 | Oncology Research2023，31，2： | 0 |
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