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| 1 | β5整合素在造血细胞上的表达和诱导细胞凋亡的作用显示文摘目的 研究整合素 (integrins)αvβ5对造血细胞功能的影响。 方法 用逆转录病毒载体系统将αv、β5基因转染K5 6 2细胞 ,观察αv、β5亚基的表达 ;用去除血清的方法 ,观察造血细胞凋亡和分化时αvβ5和αvβ3的变化 ;用抗αvβ5单抗屏蔽造血细胞上αvβ5时对凋亡和增殖的影响。 结果 将含有 β5基因的逆转录病毒导入K5 6 2细胞 ,β5亚基没有得到表达 ;诱导造血细胞分化和凋亡时 ,αvβ5表达升高 ,而αvβ3表达下降 ;用单抗封闭细胞表面的αvβ5 ,可抑制去血清诱导的细胞凋亡。 结论 造血细胞αvβ5的过度表达可抑制细胞增殖并与细胞凋亡有关。 | 殷莲华 赵新永 付四清 F Garacia-Sanchez AB Deisseroth | 2001 | 中华血液学杂志2001，22，1： | 3 |
| 2 | Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials显示文摘 | Mermelstein PG Bito H Deisseroth K | 2000 | J Neurosci2000，20，1： | 1 |
| 3 | Use of safety-modified reroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer:a pilot trial显示文摘 | Deisseroth AB Holmes F Hortobagyi G | 1996 | Hum Gene Ther1996，7，3： | 1 |
| 4 | Reversi- ble online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex 显示文摘 | SMITH K S VIRKUD A DEISSEROTH K | 2012 | Proc Natl Acad Sci U S A2012，109，18： | 1 |
| 5 | Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model显示文摘 | ZALOCUSKY K DEISSEROTH K | 2013 | Optogenetics2013，1，： | 1 |
| 6 | Catalase:physical and chemical properties, mechanism of catalysis, and physiological role 显示文摘 | Deisseroth A Dounce A | 1970 | Physiol Rev1970，50，： | 1 |
| 7 | Polymorphism at codon 72 of the P53 gene in human acute myelogenous leukemia显示文摘 | Zhang W Hu GY Deisseroth A | 1992 | Gene1992，117，27： | 1 |
| 8 | Spaced stimulistabilize MAPK pathway activation and its effects on dendriticmorphology显示文摘 | Wu GY Deisseroth K Tsien RW | 2001 | Nat Neurosci2001，4，2： | 1 |
| 9 | Optogcnetics 显示文摘 | Deisseroth K | 2011 | Nat Methods2011，8，1： | 1 |
| 10 | Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology显示文摘 | Wu G Y Deisseroth K Tsien R W | 2001 | Nat Neurosci2001，4，2： | 1 |
| 11 | Tumor vascular targeting therapy with viral vectors显示文摘 | Liu YZ Deisseroth A | | 0，，： | 1 |
| 12 | Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons显示文摘 | Deisseroth K Heist EK Tsien RW | 1998 | Nature1998，392，： | 1 |
| 13 | Activity-dependent CREB phosphorylation:Convergence of a fast,sensitive calmodulin kinase pathway and a slow,less sensitive mitogen-activated protein kinase pathway显示文摘 | Wu G Y Deisseroth K Tsien R W | 2001 | PNAS2001，98，： | 1 |
| 14 | BCR-ABL protein ex- pression in peripheral blood cells of chronic myelogenous leukemia pa- tients undergoing therapy显示文摘 | Guo JQ Lian JY Xian YM Lee M-S Deisseroth AB Stass SA Champ- lin RE Talpas M Wang JYJ Arlinghaus RB | 1994 | Blood1994，，83： | 1 |
| 15 | Millisecond-timescale,genetically targeted optical control of neural activity显示文摘 | Boyden E S Nagel G Deisseroth K | 2005 | Nat Neu-rosci2005，8，9： | 1 |
| 16 | Signaling from synapse to nucleus: the logic behind the mechanisms 显示文摘 | Deisseroth K Mermelstein PG Xia H | 2003 | Curr Opin Neurobio12003，13，3： | 1 |
| 17 | Chronic myelogenous leukemia:a concise update显示文摘 | Kantarjian HM Deisseroth A Kurzrock R | 1993 | Blood1993，82，： | 1 |
| 18 | Light microscopy mapping of connections in the intact brain 显示文摘 | Kim SY Chung K Deisseroth K | 2013 | Trends Cogn Sci2013，17，12： | 1 |
| 19 | Optogenetics 显示文摘 | Deisseroth K | 2011 | Nature methods2011，8，1： | 1 |
| 20 | CREB phosphorylation and dephosphorylation:a Ca(2+)-and stimulus duration-dependent switch for hippocampal gene expression显示文摘 | BITO H DEISSEROTH K TSIEN R W | 1996 | Cell1996，87，7： | 1 |
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