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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair 显示文摘 | Kuhn B del Monte F Hajjar R J | 2007 | Nat Med2007，13，8： | 1 |
| 3 | Prospects for gene therapy for heart failure显示文摘 | Hajjar RJ del Monte F Matsui T | 2000 | Circ Res2000，86，6： | 1 |
| 4 | Adenoviral gene transfer of SERCA2a improves left- ventricular function in aortic- banded rats in transition to heart failure 显示文摘 | Miyamoto MI del Monte F Schmidt U | 2000 | Pro Natl Acad Sci USA2000，97，2： | 1 |
| 5 | Adenoviral gene transfer of activated phosphatidylinositol 3-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro 显示文摘 | Matsui T Li L del Monte F | 1999 | Circulation1999，100，23： | 1 |
| 6 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair显示文摘 | Kuhn B del Monte F Hajjar R J | 2007 | Nat Med2007，13，8： | 1 |
| 7 | Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo显示文摘 | Matsui T Tao J del Monte F | 2001 | Circulation2001，104，： | 1 |
| 8 | Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro显示文摘 | Matsui T Li L del Monte F | 1999 | Circulation1999，100，23： | 1 |
| 9 | Muhiple endocrine neoplasia type 2 显示文摘 | Marini F Fah'hetti A Del Monte F | 2006 | Orphanel J Rar Dis2006，1，： | 1 |
| 10 | Optimization of HS–SPME/GC–MS analysis and its use in the profiling of illicit ecstasy tablets(Part 1)显示文摘 | Bonadio F Margot P Delémont O | 2009 | Forensic Science International2009，187，13： | 1 |
| 11 | Multiple endocrine neoplasia type 2显示文摘 | Marini F Falchetti A Del Monte F | 2006 | Orphanet J Rare Dis2006，1，： | 1 |
| 12 | Overwhehning evidence of the beneficial effects of SERCA gene transfer in heart failure 显示文摘 | del Monte F Hajjar RJ Harding SE | 2001 | CircRes2001，88，11： | 1 |
| 13 | Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in viva显示文摘 | Matsui T Tan J del Monte F | 2001 | Circulation2001，104，3： | 1 |
| 14 | Adenoviral gene transfer of SERCA2a improves left ventricular function in aortic-banded rats in transition to heart failure显示文摘 | Miyamoto MI del Monte F Schmidt U | 2000 | Proc Natl Acad Sci USA2000，97，2： | 1 |
| 15 | Adenoviral gene transfer of activated phosphatidylinositol 3'-Kinase and Akt inhibits apoptosis of hypoxic cardio-myocytes in vitro显示文摘 | Matsui T Li L del Monte F | 1999 | Circulation1999，100，23： | 1 |
| 16 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair显示文摘 | Kuhn B del Monte F Hajjar R J | 2007 | Nat Med2007，13，8： | 1 |
| 17 | Adenoviral gene transfer of activated PI 3-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro显示文摘 | Li L del Monte F | 1999 | Circulation1999，100，： | 1 |
| 18 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair显示文摘 | Kühn B del Monte F Hajjar RJ | 2007 | Nature Med2007，13，： | 1 |
| 19 | Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo显示文摘 | MATSUI T TAO J DEL MONTE F | 2001 | Circulation2001，104，： | 1 |
| 20 | Targeting Phospholamban by Gene Transfer in human Heart Fai lure显示文摘 | del Monte F Harding S E Dec G W | 2002 | Circulation2002，105，： | 1 |
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