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| 1 | Comparison of the liver stiffness measurement by transient elastography with the liver biopsy显示文摘AIM: To compare the liver stiffness (LS) measurement by transient elastography (TE) to the liver biopsy (LB)-considered the 'gold standard' in the evaluation of patients with chronic hepatitis C. METHODS: During a period of 12 mo, we evaluated 199 consecutive patients with chronic hepatitis due to hepatitis C virus (HCV), in which LB and LS assessments (by means of TE) were performed during the same session. RESULTS: Out of 199 patients, a valid measurement of the LS could not be obtained in 8. The mean value of LS in the cohort of 191 valid measurements was 8.45 ± 4.96 kPa, ranging from 2.3 to 38 kPa. The mean value of LS in patients with signifi cant fi brosis at biopsy (161 patients with F ≥ 2 according to Metavir) was 9.02 ± 5.15 kPa, significantly higher than in patients with no or mild fi brosis (30 patients with F < 2 Metavir): 5.39 ± 1.81 kPa (P < 0.0001). For a cut- off value of 6.8 kPa, the LS had a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6% and a specificity of 93.3% for the presence of signifi cant fi brosis (at least F2 Metavir), with a diagnostic performance of 77.3% (AUROC 0.773). Using this cut-off value, we reached the best discrimination between absence of fibrosis/ mild fibrosis (F < 2 Metavir) and the presence ofmoderate to severe fi brosis (F ≥ 2 Metavir). CONCLUSION: In patients with chronic hepatitis due to HCV, a cut-off value of 6.8 kPa measured by TE can differentiate between significant fibrosis and absent or mild fi brosis, with a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6%, a specificity of 93.3%, and a diagnostic performance of 77.3%. | Ioan Sporea Roxana ■irli Alexandra Deleanu Adriana Tudora Manuela Curescu Marioara Cornianu Daniela Lazǎr | 2008 | World Journal of Gastroenterology2008，14，42： | 20 |
| 2 | Liver stiffness measurements in patients with HBV vs HCV chronic hepatitis:A comparative study显示文摘AIM:To assess the values of liver stiffness (LS) in pa-tients with hepatitis B virus (HBV) chronic hepatitis and to compare them with those in patients with hepatitis C virus (HCV) chronic hepatitis. METHODS: The study included 140 patients with HBV chronic hepatitis, and 317 patients with HCV chronic hepatitis, in which LS was measured (FibroScan-Echo-sens) and liver biopsy was performed in the same session (assessed according to the Metavir score). RESULTS:According to the Metavir score of the 140 HBV patients: one had F0,32 had F1, 67 had F2,33 had F3 and 7 had F4. Of the 317 HCV patients:5 had F0, 34 had F1, 146 had F2, 93 had F3 and 39 had F4. For the same severity of fibrosis, the mean values of LS in HBV patients were similar to those in HCV patients:F1,6.5±1.9 kPa vs 5.8±2.1 kPa (P=0.0889); F2,7.1±2 kPa vs 6.9±2.5 kPa (P = 0.3369); F3,9.1±3.6 kPa vs 9.9±5 kPa (P=0.7038); F4,19.8± 8.6 kPa vs 17.3±6.1 kPa (P=0.6574). A signif icant direct correlation between LS measurements and fibrosis was found in HCV patients (Spearman’s r=0.578, P<0.0001), as well as in HBV patients (r=0.408, P<0.0001). The correlation was more signif icant in HCV than in HBV patients (Fisher’s Z-test,Z= 2.210,P=0.0271). CONCLUSION:In our group, the mean values of LS in patients with chronic B hepatitis were similar to those in patients with chronic HCV hepatitis, for the same stage of f ibrosis. Also, LS was correlated with the severity of fibrosis both in HBV and HCV chronic hepatitis patients. | Ioan Sporea Roxana Sirli Alexandra Deleanu Adriana Tudora Alina Popescu Manuela Curescu Simona Bota | 2010 | World Journal of Gastroenterology2010，16，38： | 19 |
| 3 | 经皮冠状动脉介入的遥控操作:概念、验证和首次人体临床试验显示文摘OBJECTIVES: This study was designed to assess the feasibility and safety of a Remote Navigation System(RNS, NaviCath, Haifa, Israel) in which the angioplasty guidewire, the balloon, and the stent are navigated via a computerized system. BACKGROUND: Percutaneous coronary interventions(PCIs) are manually performed under fluoroscopic guidance, requiring lead protection for the operators. A system in which the operator can remotely, safely, and precisely navigate the procedure during PCI would have clear advantages. METHODS: The RNS involves a computer-controlled wire and delivery system navigator. Following preclinical validation, the system was assessed in patients undergoing single-vessel PCI. RESULTS: The study involved 18 patients(age 55.9 years, 16% women). The RNS successfully crossed lesions with the guidewire in 17 patients. The stent was then advanced by the advance/rotate mode and adequately positioned in 15 of 17 cases. Technical malfunction was encountered in three patients in whom the procedure was successfully completed manually. Direct stenting was employed in 10 of 18 patients,pre-dilation in 7 patients, and after-stent balloon dilation in 5 patients. The total fluoroscopy time for 17 RNS patients was compared with the corresponding time of 20 consecutive patients who underwent standard single lesion PCI. Fluoroscopy time was similar for both procedures, with 8.8± 4.8 min with the RNS versus 9.1± 3.5 min with the standard techniques(p=NS). Clinical success was 100% and technical success 94% for the guidewire and 83% for the overall procedure. CONCLUSIONS: The use of the RNS for guidewire, balloon, and stent manipulation during PCI appears safe and feasible for the treatment of patients with coronary stenosis. The system offers operator radiation safety and may enhance precision of stent placement and balloon dilation strategies. | Beyar R Gruberg L Deleanu D. 徐永城 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 3 |
| 4 | Liver stiffness evaluated through transient elastography in patients chronicaly infected with HBV 显示文摘 | Sporea I Sirli R Deleanu A | 2009 | Hepatology2009，50，： | 1 |
| 5 | Existence of the Adams completion for objects of cocomplete categories显示文摘 | DELEANU A | 1973 | J of Pure and Appl Algebra1973，6，： | 1 |
| 6 | Existenee of the Adams completion for CW- complexes显示文摘 | DELEANU A | 1974 | J of Pure and Appl Algebra1974，4，： | 1 |
| 7 | Probiotics determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters 显示文摘 | Stancu C S Sanda G M Deleanu M | 2013 | Molecular Nutrition & Food Research2013，58，3： | 1 |
| 8 | Comparative study of the sol-gel processes starting with different substituted Si-alkoxides显示文摘 | Andrei Jitianu Alina Britchi Calin Deleanu | 2003 | J Non-Cryst Solid2003，319，3： | 1 |
| 9 | 显示文摘 | Andrei Jitianu Alina Brutchi Calin Deleanu | 2003 | Journal of Non-Crystalline Solid2003，319，3： | 1 |
| 10 | Determination of the epoxide equivalent weight (EEW) of epoxy resins with different chemical structure and functionality using GPC and 1H-NMR 显示文摘 | Garea S A Corbu A C Deleanu C | 2006 | Polymer Testing2006，25，： | 1 |
| 11 | Local thrombolytic treatment for renal arterial embolism 显示文摘 | Gluck G Croitoru M Deleanu D | 2000 | Eur Urol2000，38，3： | 1 |
| 12 | Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications显示文摘Obstructive sleep apnea syndrome(OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular disease, stroke, metabolic disorders, occupational errors, motor vehicle accidents and even death. Thus, OSAS has severe consequences and represents a significant economic burden. However, some of the consequences, as well as their costs can be reduced with appropriate detection and treatment. In this context, the recent advances that were made in stem cell biology knowledge and stem cell- based technologies hold a great promise for various medical conditions, including respiratory diseases. However, the investigation of the role of stem cells in OSAS is still recent and rather limited, requiring further studies, both in animal models and humans. The goal of this review is to summarize the current state of knowledge regarding both lung resident as well as circulating stem/progenitor cells and discuss existing controversies in the field in order to identify future research directions for clinical applications in OSAS. Also, the paper highlights the requisite for inter-institutional, multi-disciplinary research collaborations in order to achieve breakthrough results in the field. | Miruna Mihaela Micheu Ana-Maria Rosca Oana-Claudia Deleanu | 2016 | World Journal of Stem Cells2016，8，10： | 1 |
| 13 | Obstructive sleep apnea syndrome and arterial hypertension-a complicatod rela- tionship? The role of eontrolling blood pressure values in patients with OSAS显示文摘 | Deleanu O C Malaut A E Nebunuiu A M | 2014 | Pneumologia2014，63，1： | 1 |
| 14 | Acoustic radiation force impulse elastogrphy as compared to transient elastography and liver biopsy in patients with chronic hepatopathies 显示文摘 | Sporea I Sirli RL Deleanu A | 2011 | Uhrachall Med2011，32，1： | 1 |
| 15 | Comparative study of the sol-gel processes starting with different substituted Si-alkoxides显示文摘 | Andrei Jitianu Alina Britchi Calin Deleanu | 2003 | Journal of Non-Crystalline Solids2003，319，3： | 1 |
| 16 | What did we learn from thefirst 3,459 cases of liver stiffness measurement by transient elas-tography (FibroScan)? 显示文摘 | Sporea I Sirli RL Deleanu A | 2011 | Ultraschall Med2011，32，1： | 1 |
| 17 | Local thrombolytic treatment for renal arterial embolism显示文摘 | Cluck G Croitoru M Deleanu D | 2000 | Eur Urol2000，38，3： | 1 |
| 18 | What did we learn from the first 3,459 cases of liver stiffness measurement by transient elastography (FibroScan)? 显示文摘 | Sporea I Sirli R Deleanu A | 2011 | UltraschaU in der Medizin (Stuttgart Germany: 1980)2011，32，1： | 1 |
| 19 | Acute abdominalcomplications following hip surgery 显示文摘 | Deleanu B Prejbeanu H Vermesan D | 2014 | Chirurgia ( Bucur )2014，109，2： | 1 |
| 20 | Remote-controlpercutaneous coronary interventions:concept,validation,and first-in-humans pilot clinical trial显示文摘 | Beyar R Gruberg L Deleanu D | 2006 | Journal of the American College of Cardiology2006，47，2： | 1 |
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