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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Novel approaches for the treatment of ventricular tachycardia显示文摘Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications. | Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis | 2018 | World Journal of Cardiology2018，10，7： | 2 |
| 3 | Distribution of endocrine disruptors in the Llobregat River basin (Catalonia,NE Spmn)显示文摘 | Raquel Céspedes Sílvia Lacorte Demetrio Raldúa | 2005 | Chemosphere2005，61，11： | 1 |
| 4 | Theory of stimula- ted Raman scattering cancellation in wavelength-division- ultiplexed systems via spectral inversion 显示文摘 | Alexandra G G Demetrios N C Jean T | 1999 | Photonics Technology Letters1999，11，10： | 1 |
| 5 | Beitrage zur Pilzflora von Missouri显示文摘 | Demetrio C H | | Hedwigia0，24，： | 1 |
| 6 | Planktic foraminifera from the southwestern Atlantic(30°-60°S):species-specific patterns in the upper 50m显示文摘 | ESTEBAN B DEMETRIO B NANCY C | 1996 | Mar Micropaleontology1996，28，： | 1 |
| 7 | Overdispersion: models and estimation显示文摘 | HINDE J DEMETRIO C G B | 1998 | Computational Statistics and Data Analysis1998，27，2： | 1 |
| 8 | Study of conductivity of dEPDM rubber and PAni blends显示文摘 | DANIELA A A JOSE C M DEMETRIO A W S | 2007 | Macromolecular Symposia2007，，1： | 1 |
| 9 | Approach to the management of complex hepatic injuries显示文摘 | Juan AA Demetrios D Santiago C | | 0，，01： | 1 |
| 10 | A Score Test for Testing a Zero - inflated Poisson Regression Model Against Zero - inflated Negative Alternatives显示文摘 | Ridout M Hinde J Demetrio C G B | 2001 | Biometrics2001，，57： | 1 |
| 11 | Synthesis and antiproliferativeactivity of 3-amino-N-phenyl- 1H-indazole- 1- carboxamides 显示文摘 | Demetrio R Benedetta M Stella C A | 2009 | European Journal of Medicinal Chemistry2009，44，1： | 1 |
| 12 | A Score test for testing a zero-inflated poisson regression model against zero-inflated negative binomial alternatives显示文摘 | RIDOUT M HINDE J DEMETRIO C G B | 2001 | Biometrics2001，57，： | 1 |
| 13 | Standardization of a duplex RT-PCR for the detection of Influenza A and Newcastle disease viruses in migratory birds显示文摘 | Soares P B Demetrio C Sanfilippo L | 2005 | J Virol Methods2005，123，2： | 1 |
| 14 | Life Support for Trauma and Transport: a mobile ICU for safe in-hospital transport of critically injured patients 1 1 No competing interests declared.显示文摘 | George C Velmahos Demetrios Demetriades Mariano Ghilardi Peter Rhee Patrizio Petrone Linda S Chan | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 15 | Over-dispersion: models and estimation显示文摘 | HINDE J DEMETRIO C | 1998 | Computational Statistics & Data Analaysis1998，27，2： | 1 |
| 16 | Occurrence, fate, and behavior of brominated flame retardants in Ebro river basin (Spain) 显示文摘 | ETHEL E AGUSTINA C DEMETRIO R | 2005 | Environ Pollut2005，133，3： | 1 |
| 17 | Introduction to organic thin film transistors and design of n-Channel organic Semiconductors显示文摘 | Newman Christopher R Frisbie C Daniel da Silva Filho Demetrio A | 2004 | Chem Mater2004，16，： | 1 |
| 18 | Standardization of a duplex RT-PCR for the detection of Influenza A and Newcastle disease viruses in migratory birds 显示文摘 | Soares P B Demetrio C San- filippo L | 2005 | Virol Methods2005，123，： | 1 |
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