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9篇 您的检索式：作者名="Demuynck L"

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		题名	作者	年代	出处	被引量
	1	Zygomycosis in neutropenie patients with past AspergiUus infection: a role for posaconazole? 显示文摘	IDE L BUYSSCHAERT I DEMUYNCK H	2004	Clin Microbiol Infect2004，10，9：	1
	2	Zygomycosis in neutropenic patients with past Aspergillus infection: a role for posaconazole? 显示文摘	IDE L BUYSSCHAERT I DEMUYNCK H	2004	Clin Microbiol Infect2004，10，9：	1
	3	Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.	Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet	2022	Bone Research2022，10，1：	1
	4	Mechanisms of CVD diamond nucleation and growth on mechanically scratched and virgin Si(100) surfaces 显示文摘	Demuynck L Amault J C Speisser C	1997	Diamond Relat Mater1997，6，：	1
	5	The potential of methanol as a fuel for flex-fuel and dedicated sparkignition engines显示文摘	Vancoillie J Demuynck J Sileghemetal L	2013	Applied Energy2013，102，2：	1
	6	Results of intraperitoneal chemotherapy of ovarian cancer 显示文摘	de Gramont A Marpeau L Demuynck B	1991	J Gynecol Obstet Biol Reprod ( Paris)1991，20，3：	1
	7	Compari son of the renewable transportation fuels, hydrogen and methanol formed from hydrogen, with gasoline -Engine efficiency study 显示文摘	Vancoillie J Demuynck J Sileghem L	2012	Hydrogen Energy2012，37，：	1
	8	Infrared diode laser spectra of MgH and MgD显示文摘	LEMOINE B DEMUYNCK K DESTOMBES J L	1988	Journal of Chemical Physics1988，89，：	1
	9	The potential of methanol as a fuel for flex-fuel and dedicated spark-ignition engines显示文摘	Vancoillie J Demuynck J Sileghem L	2013	Applied Energy2013，102，：	1

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