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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 3 | Development of a Rapid and Sensitive Method Combining a Cellulose Ester Mierofilter and a Real-Time Quantitative PCR Assay To Detect Campylobacter jejuni and Campylobacter eoli in 20 Liters of Drinking Water or Low-Turbidity Waters显示文摘 | Tissie A Denis M Hartemann P | 2012 | Applied and environmental microbiology2012，78，3： | 1 |
| 4 | miR-203 modulates epithelial d- ifferentiation of human embryonic stem ceils towards epidermal strati- fication显示文摘 | X Nissan J A Denis M Saidani | 2011 | Dev Biol2011，356，2： | 1 |
| 5 | Design of a new photonic cover to increase antenna directivity 显示文摘 | THEVENOT M DENIS M S REINEIX A | 1999 | Microwave and Optical Technology Letters1999，22，2： | 1 |
| 6 | Saturated faTTy acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus:implications for the pathogenesis of obesity显示文摘 | Milanski M Degasperi G Coope A Morari J Denis R Cintra D E Tsukumo D M Anhe G | | 0，，02： | 1 |
| 7 | Synthesis and sorption properties of a polyarnpholyte 显示文摘 | DENIS M F L CARBALLO R R SPIAGGI A J | 2008 | Reactive & Functional Polymers2008，68，： | 1 |
| 8 | Influence of aminosilane surface fimctionalization of rare earth hydride-forraing alloys on palladium treatment by electroless deposition and hydrogen sorption kinetics of composite materials 显示文摘 | WILLIAMS M NECHAEV A N LOTOTSKY M V YARTYS V A SOLBERG J K DENYS R V PINEDA C LI Q LINKOV V M | 2009 | Mater Chem Phys2009，115，1： | 1 |
| 9 | Mathematical model coupling phased transformation and temperature evolution dur- ing quenching of steels 显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technolo- gy1985，1，10： | 1 |
| 10 | Nonoperative management of traumatic splenic injuries : is there a role for proximal splenic artery embolization? 显示文摘 | Bessoud B Denys A Calmes J M | 2006 | Am J Roentgenol2006，186，3： | 1 |
| 11 | Parachordoma:a rare sarcoma with clonal chromosomal changes显示文摘 | Limon J Babinska M Denis A | 1998 | Cancer Genet Cytogenet1998，102，： | 1 |
| 12 | High LET radiation combined with oxaliplatin in duce autophagy in U-87 glioblastoma cells显示文摘 | Benzina S Altmeyer A Malek F Dufour P Denis J M Gueu lette J | 2008 | Cancer Lett2008，264，： | 1 |
| 13 | Prospective longitudinal assessment of change in health-related quality of life after adjustable gastric banding显示文摘 | Robert M Denis A Badol-Van Straaten P | 2013 | Obes Surg2013，23，10： | 1 |
| 14 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives) : a new class of antibacterials highly potent against macrolide-resistant and-susceptible respiratory pathogens 显示文摘 | Agouridas C Denis A Auger J M | 1998 | J Med Chem1998，41，21： | 1 |
| 15 | Prevalence of parameter indicators of obesity and its relationship with metabolic syndrome in urban Moroccan women显示文摘 | Mohammedel A Mohamed M Denis L | 2008 | Am J Hum Biol2008，20，4： | 1 |
| 16 | Mathematical Model Coupling Phase Transformation and Temperature Evolution During Quenching of Steels显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technology1985，1，10： | 1 |
| 17 | Risk of occupational blood exposure in a cohort of 24000 hospital healthcare workers:position and environment analysisover three years 显示文摘 | DENIS M A ECOCHARD R BEMADET A | 2003 | JOEM2003，45，3： | 1 |
| 18 | Validation of pulsed-field gel electrophoresis and spa typing for longterm, nationwide epidemiologieal surveillance studies of Staphylococcus aureus infections 显示文摘 | Hallin M Deplano A Denis O | 2007 | J Clin Microbiol2007，45，1： | 1 |
| 19 | A modeling approach for evaluating process uniformity during batch high hydrostatic pressure processing:combination of numerical heat transfer model and enzyme inactivation kinetics 显示文摘 | Denys S Van Loey A M Hendrickx M E | 2000 | Innovative Food Science and Emerging Technologies2000，1，1： | 1 |
| 20 | Modeling conductive heat transfer and process uniformity during batch high pressure processing of foods 显示文摘 | Denys S Ludikhuyze L R Van Loey A M | 2000 | Biotechnology Prog2000，16，1： | 1 |
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