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| 1 | Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures显示文摘BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy. METHODS: Consecutive patients were included as follows: difficult stones(group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures(group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate(group 1) and diagnostic accuracy(group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1(n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15(71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17(81.0%) patients. One serious adverse event occurred(bile duct perforation). Group 2(n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures. | Athanasios D Sioulas Muhammad A El-Masry Stefan Groth Guido Schachschal Mario Anders Thomas Rosch Ulrike Denzer | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 2 |
| 2 | Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography显示文摘 | ZINGER O ANSELME K DENZER A HABERSETZER P WIELAND M JEANFILS J HARDOUIN P LANDOLT D | 2004 | Biomaterials2004，25，14： | 1 |
| 3 | Subclinical hypothyroidism and dyslipidemia in children and adolescents with type 1 diabetes mellitus显示文摘 | Denzer C Karges B Nake A | 2013 | EurJ Endocrinol2013，168，： | 1 |
| 4 | Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography显示文摘 | Zinger O Anselme K Denzer A | 2004 | Biomaterials2004，25，14： | 1 |
| 5 | Metabotropic glutamate mGlu1receptor mRNA expression in dorsal root ganglia of rats after peripheral nerve injury显示文摘 | Hofmann HA Siegling A Denzer D | 2001 | Eur J Pharmacol2001，429，13： | 1 |
| 6 | Pubertal development inobese children and adolescents显示文摘 | Denzer C Weibel A Muche R | 2007 | Int J Obes(Lond)2007，31，10： | 1 |
| 7 | Rela- tionship between fracture toughness, fracture path, and mi- crostructure of 7050 aluminum alloy: Part I Quantitative characterization显示文摘 | Deshpande N U Gokhale A M Denzer D K | 1998 | Metall Mater Trans A1998，29，4： | 1 |
| 8 | Cellular and humoral immune response against autoreactive T cells in multiple sclerosis patients after T cell vaccination显示文摘 | Hermans G Denzer U Lohse A | 1999 | J Autoimmu1999，，： | 1 |
| 9 | Relationship between fracture toughness, fracture path, and mierostructure of 7050 aluminum alloy, part I: quantitative characterization显示文摘 | DESHPANDE N U C OKHALE A M DENZER D K etal | 1998 | Metall Mater Trans A1998，29，： | 1 |
| 10 | Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathie pain 显示文摘 | Siegling A Hofmann HA Denzer D | 2001 | Eur J Pharmacol2001，415，： | 1 |
| 11 | Time- dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography显示文摘 | ZINGER O ANSELME K DENZER A | 2004 | Biomaterials2004，25，： | 1 |
| 12 | Relationship between fracture toughness,fracture path and microstructure of 7050 aluminum alloy (Part Ⅰ):Quantitative characterization显示文摘 | Deshpasde N Q Gorhale A M Denzer D K | 1998 | Metall Trans A1998，29，4： | 1 |
| 13 | Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale- resolved topography显示文摘 | Zinger O Anselme K Denzer A et td | 2004 | Biomaterials2004，25，14： | 1 |
| 14 | Pubertal development in obese children and adolescents显示文摘 | Denzer C Weibel A Muche R | | 0，，10： | 1 |
| 15 | Pubertal development in obese children and adolescents显示文摘 | Denzer C Weibel A Muche R | 2007 | Int J Obes (Lond)2007，31，10： | 1 |
| 16 | Pubertal development in obese children and adolescents显示文摘 | Denzer C Weibel A Muche R | 2007 | Int J Obes (Lond)2007，31，： | 1 |
| 17 | Cellular and humoral immune responses against autoreactive T cells in multiple sclerosis patients after T cell vaccination显示文摘 | Hermans G Denzer U Lohse A | 1999 | J Autoimmun1999，13，2： | 1 |
| 18 | Time - dependent morphology and adhesion of osteoblastic ceils on titanium model surfaces featuring scale - resolved topography 显示文摘 | Zinger O Anselme K Denzer A | 2004 | Biomaterials2004，25，： | 1 |
| 19 | Subclinical hypothyroidismand dyslipidemia in children and adolescents with type 1 diabetesmellitus显示文摘 | Denzer C Karges B Nike A | 2013 | Eur J Endocrinol2013，168，4： | 1 |
| 20 | Time dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography 显示文摘 | Zinger O Anselme K Denzer A | 2004 | Bilmaterials2004，5，： | 1 |
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