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| 1 | Colorectal cancer of the young displays distinct features of aggressive tumor biology:A single-center cohort study显示文摘BACKGROUND In recent years,a decrease in incidence and mortality of colorectal cancer(CRC)has been observed in developed nations,presumably through public disease awareness and increased screening efforts.However,a rising incidence of CRC in young patients below the age of 50 years has been reported in several studies.AIM To study tumor biology in CRC patients below 50 years of age.METHODS All patients with CRC were prospectively enrolled in our single-center oncologic database from January 2013 to December 2018 and were grouped and analyzed according to age(≥50 and<50 years).Clinical as well as histopathological features were analyzed and compared.The study was approved by the local Ethics Committee.Fisher’s exact test or t-test was used to test for differences between the groups,as appropriate.All statistical analysis was performed with IBM SPSS software Version 25(SPSS Inc,Armonk,NY,United States)and with RStudio using R Version 3.4.1(RStudio,Boston,MA,United States).RESULTS Seventeen percent of the 411 patients were younger than 50 years.Young patients were more often diagnosed with locally advanced T4-tumors and lymph node metastases(36.6%and 62%vs 17.7%and 42%;P<0.01).In addition,a higher frequency of poorly differentiated(G3)tumors(40%vs 22.4%P<0.05)was observed.More than every second patient below 40 years of age(51.8%)had distant metastases at diagnosis with a significant higher rate ring of signet cell differentiation compared to patients≥50 years(14.8%,P<0.05).Mutational status(KRAS,NRAS,BRAF,MSI)as well as selected behavioral risk factors showed no significant differences.CONCLUSION Distinct histopathologic features of increased biologic aggressiveness are found in patients with CRC of young-onset.Those patients present more frequently with more advanced tumor stages compared to older patients.Features of aggressive tumor biology underscore the need for earlier uptake of routine screening measures. | Matteo Mueller Marcel Andre Schneider Barla Deplazes Daniela Cabalzar-Wondberg Andreas Rickenbacher Matthias Turina | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 2 | Comparing apical preparaions of root canals shaped by nicklcel-titanium rotary instruments and nickel-titanium hand instruments 显示文摘 | Deplazes P Peters O Barbakow F | 2001 | Endod2001，27，30： | 1 |
| 3 | Single nucleotide variation in rDNA ITS-2 differentiates Psoroptes isolates from sheep and rabbits from the same geographical area显示文摘 | Ochs H Mathis A Deplazes P | 1999 | Parasitology1999，119，： | 1 |
| 4 | Generalized Tacnia cras- siceps cysticereosis in a chinchilla ( Chinchilla lanigera ) 显示文摘 | Basso W ROtten M Deplazes P ctal | 2014 | VetParasltol2014，199，2： | 1 |
| 5 | A monoclonal antibody against Ech-inococcus multilocularis Em2 antigen 显示文摘 | Gottstein B | 1991 | Parasitol1991，103，1： | 1 |
| 6 | Biological,epidemiological,and clinical aspects of echinococcosis,a zoonosis of increasing concern显示文摘 | JOHANNES ECKERT PETER DEPLAZES | 2004 | Clinical Microbiology Reviews2004，17，1： | 1 |
| 7 | Age, season and spatio-temporal factors affecting the prevalence of Echinococcus muhilocularis and Taenia taeniaeformis in Arvicola terrestris显示文摘 | Pierre Burlet Peter Deplazes and Daniel Hegglin | 2011 | Parasites & Vectors2011，，4： | 1 |
| 8 | F-18-Fluorodeoxyglucose (FDG) Positron-Emission Tomography of Echinococcus multilocularis Liver Lesions: Prospective Evaluation of its Value for Diagnosis and Follow-up during Benzimidazole Therapy显示文摘 | K. D. M. Stumpe E. C. Renner-Schneiter A. K. Kuenzle F. Grimm Z. Kadry P.-A. Clavien P. Deplazes G. K. Schulthess B. Muellhaupt R. W. Ammann E. L. Renner | 2007 | Infection2007，，1： | 1 |
| 9 | Global socioeconomic impact of cystic echinococcosis显示文摘 | Budke CM Deplazes P Torgerson PR | 2006 | Emerg Infect Dis2006，12，2： | 1 |
| 10 | Global socioeconomic im- pact of cystic echinococcosis 显示文摘 | Budke CM Deplazes P Torgerson PR | 2006 | Emerg Infect Dis2006，12，2： | 1 |
| 11 | Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves显示文摘 | M. Schnyder L. Kohler A. Hemphill P. Deplazes | 2008 | Veterinary Parasitology2008，，1： | 1 |
| 12 | Ribosomal and mitochondrial DNA analysis of Trichuridae nematodes of carnivores and small mammals显示文摘 | Guardone L Deplazes P Macchioni F | 2013 | Vet Parasitol2013，197，12： | 1 |
| 13 | Zoonotic potential of the microsporidia显示文摘 | Mathis A Weber R Deplazes P | 2005 | Clin Microbiol Rev2005，18，3： | 1 |
| 14 | Comparing apical preparations of root canals shaped by nickel-titanium rotary instruments and nickel-titanium hand instruments显示文摘 | Deplazes P Peters 0 Barbakow F | 2001 | J Endod2001，27，3： | 1 |
| 15 | Comparing apical prepara-tions of root canals shaped by nickel-titanium rotary instru-ments and nickel-titanium hand instruments显示文摘 | Deplazes P Peters O Barbakow F | | 0，，3： | 1 |
| 16 | Diagnostic idenlification of Taenia saginata with the polymerase chain reaction显示文摘 | Gottstein B Deplaze P Tanner I | 1991 | Trans R Soc Trop Med Hyg1991，85，2： | 1 |
| 17 | Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern显示文摘 | Eckert J Deplazes P | 2004 | Clin Microbiol Rev2004，17，1： | 1 |
| 18 | Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease显示文摘 | Kraft C Deplazes A Sohrmann M | 2008 | Nat Cell Biol2008，10，： | 1 |
| 19 | Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern 显示文摘 | Eckert J Deplazes P | 2004 | Clinical Microbiology Reviews2004，17，1： | 1 |
| 20 | A monoclonal antibody against Echinococcus multilocularis Era2 antigen 显示文摘 | Deplazes P Gottstein B | 1991 | Parasitology1991，103，1： | 1 |
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