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| 1 | Review of the diagnosis,classification and management of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP)is a rare form of chronic pancreatitis,with as yet undetermined incidence and prevalence in the general population.Our understanding of it continues to evolve.In the last few years,2separate subtypes have been identified:type 1 AIP has been recognised as the pancreatic manifestation of a multiorgan disease,named immunoglobulin G4(IgG4)-related disease while type 2 AIP is a pancreas specific disorder not associated with IgG4.International criteria for the diagnosis of AIP have been defined:the HISORt criteria from the Mayo clinic,the Japan consensus criteria and,most recently,the international association of pancreatology'International Consensus Diagnostic Criteria'.Despite this,in clinical practice it can still be very difficult to confirm the diagnosis and differenti-ate AIP from a pancreatic cancer.There are no large studies into the long-term prognosis and management of relapses of AIP,and there is even less information at present regarding the Type 2 AIP subtype.Further studies are necessary to clarify the pathogenesis,treatment and long-term outcomes of this disease.Critically for clinicians,making the correct diagnosis and differentiating the disease from pancreatic cancer is of the utmost importance and the greatest challenge. | Derek A O'Reilly Deep J Malde Trish Duncan Madhu Rao Rafik Filobbos | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 14 |
| 2 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 3 | Massive polymorphism and natural selection in Donacilla cornea显示文摘 | DEREK A A W DENIS F O | 1997 | Biological Journal of the Linnean Society1997，62，： | 1 |
| 4 | Biopsy of solid liver tumors:adverse consequences显示文摘BACKGROUND:Percutaneous radiologically-guided liver biopsy is used routinely worldwide in all secondary- level hospital centers.While it has an undoubted role in the investigation and management of acute and chronic inflammatory conditions of the liver,its role in hepatic oncology is doubtful and probably dangerous. METHOD:We report on two patients who underwent preoperative biopsy of potentially resectable liver tumors. RESULTS:At the time of surgery,there was evidence of seeding at the biopsy site in both cases.In case 1,potentially curative liver resection was rendered incurable because of gross peritoneal carcinomatosis lying adjacent to the site of liver biopsy.In case 2,the patient underwent curative liver resection,but there was histopathological evidence of peritoneal disease beyond the liver capsule along the falciform ligament at the site of the previous biopsy. CONCLUSIONS:No patient with a suspicious liver tumor which is thought to be malignant and has any possibility of being a potential candidate for liver surgery,should be subjected to pre-operative diagnostic biopsy in a non- specialist center. | Dhya Al-Leswas Derek A O'Reilly Graeme J Poston | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 1 |
| 5 | Identification of patients with pancreatic adenocarcinoma due to inheritable mutation:Challenges of daily clinical practice显示文摘BACKGROUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma(PDAC) could impact on patient/family.AIM To assess the referral pathways for genetic consultations in PDAC.METHODS Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer(EUROPAC)criteria.RESULTS Four-hundred patients were eligible. Of 113 patients(28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population.CONCLUSIONEarlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments. | Alexander JP Fulton Angela Lamarca Christina Nuttall Lynne McCallum Rille Pihlak Derek O'Reilly Fiona Lalloo Mairéad G McNamara Richard A Hubner Tara Clancy Juan W Valle | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 0 |
| 6 | Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease显示文摘AIM: To investigate a possible role for a recently identified polymorphism in the gene of cytochrome P450 2E1, the presence of which is associated with high activity of the enzyme. METHODS: Two hundred and thirty-nine alcohol consumers, ICD 10.1/.2 (ALC), and 208 normal controls were studied. PCR amplification of the CYP2E1 gene region was performed to assess polymorphic variation. Fisher's exact test was used to assess the data.RESULTS: Twelve normal controls (5.8%) possessed the insertion. Five ALC (2.1%) had the insertion; of these 2 of 144 with,alcohol induced chronic pancreatitis, none of 28 with alcoholic liver disease and 3 of 67 without endorgan disease had the polymorphism. A significantly Lower frequency of subjects possessed the insertion than normal controls [P = 0.049 (genotype analysis P = 0.03)]. To further assess, if there was a relationship to alcohol problems per se or end-organ disease, we compared patients with alcohol induced end-organ disease vs alcoholic controls without end-organ disease vs normal controls which again showed a significant difference [P = 0.045 (genotype analysis,P = 0.011)], further sub-group analysis did not identify which group(s) accounted for these differences.CONCLUSION: We have shown the frequencies of this high-activity polymorphism in alcohol related patient groups for the first time. The frequency is significantly less in alcoholics than normal controls, as with high activity polymorphisms of alcohol dehydrogenase. The biological significance, and whether the relevance is solely for alcoholism or is there a relationship to end-organ disease,would benefit from the assessment in the populations with a greater frequency of this polymorphism. | Mark T Cartmell Hans-Ulrich Schulz Derek A O'Reilly Bing'Mei Yang Volker Kielstein Simon P Dunlop Walter Halangk Andrew G Demaine Andrew N Kingsnorth | 2005 | World Journal of Gastroenterology2005，11，41： | 0 |
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