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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Direct electrochemical reduction of titanium dioxide to titanium in molten calcium chloride显示文摘 | George Z Chen Derek J Fray Tom W Farthing | 2000 | Nature2000，407，21： | 1 |
| 3 | Novel pharmacologicapproaches to the management of sepsis: targeting the host in- flammatory response显示文摘 | Derek SW Basilia Z William JW | 2009 | Recent Pat Inflamm Allergy Drug Dis- coy2009，3，2： | 1 |
| 4 | Bandwidth skinning:A technique for cost-effective video-on-demand显示文摘 | Mary V John Z | 2000 | Proc Multimedia Computing and Networking2000，，1： | 1 |
| 5 | Toward optimisation of electrolytic reduction of solid chromium oxide to chromium powder in molten chloride salts显示文摘 | Gordo Elena Chen George Z Fray Derek J | 2004 | Electrochimica Acta2004，49，： | 1 |
| 6 | Recent advances in our understanding of insulin action and insulin resistance显示文摘 | Derek LR Yehiel Z | 2001 | Diabetes Care2001，24，3： | 1 |
| 7 | Bandwidth skimming:A technique for cost-effective video-on-demand显示文摘 | DEREK E MARY V JOHN Z | 2000 | Proc Multimedia Computing and Networking2000，2000，： | 1 |
| 8 | Scale up study of retreat curve impeller stirred tanks using LDA measurements and CFD simulation显示文摘 | Li M Z Graeme W Derek W | 2005 | Chemical Engineering Journal2005，108，： | 1 |
| 9 | Toward Optimisation of Electrolytic Reduction of Solid Chromium Oxide to Chromium Powder in Molten Chloride Salts显示文摘 | Gordo Elena Chen George Z Fray Derek J | 2004 | Electrochimica Acta2004，49，： | 1 |
| 10 | Sintering effects on dielectric properties of (Ba,Sr)TiO 3 ceramics显示文摘 | L Szymczak Z Ujma J Ha?derek J Kapusta | 2004 | Ceramics International2004，，6： | 1 |
| 11 | Circadian expression of clock-and tumor suppressor genes in human oral mucosa 显示文摘 | Derek Z Isabel J Ingmar K | 2010 | Cell Physiol Biochem2010，26，2： | 1 |
| 12 | Volta metric studies of the oxygen-titanium binary system in molten calcium chloride 显示文摘 | George Z Chen Derek J Fray | 2002 | J Electrochemical Soc2002，149，11： | 1 |
| 13 | Recent advances in our understanding of insulin action and insulin resistance显示文摘 | Derek LR Yehiel Z | 2001 | Diabetes Care2001，24，3： | 1 |
| 14 | Volta metric Studies of the Oxygen-Titanium Binary System in Molten Calcium 显示文摘 | Chen George Z Fray Derek J | 2002 | Chloride Journal of the Electrochemical Society2002，149，11： | 1 |
| 15 | Direct electrochemical reduction of titanium dioxide to titanium in molten calcium chloride显示文摘 | George Z C Derek J F Tom W F | 2000 | Nature2000，407，： | 1 |
| 16 | Direct electrochemical reduction of titanium dioxide to titanium in molten calcium chloride显示文摘 | George Z C Derek J F Tom W F | 2000 | Nature2000，407，： | 1 |
| 17 | Direct Electrolytic Prepatation of Chromium Power显示文摘 | Gordo Elena Fray Derek J | 2004 | Metallurgical and Matericals Transaction B2004，35，： | 1 |
| 18 | Volta metric studies of the oxygen-titanium binary system in molten calcium chloride显示文摘 | George Z Chen Derek J Fray | 2002 | J Electrochemical Soc2002，149，11： | 1 |
| 19 | cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise显示文摘 | Derek Z Elvira F Janko D | 2005 | Physiol Genomics2005，23，： | 1 |
| 20 | To- ward optimisation of electrolytic reduction of solid chromium oxide to chromium powder in molten chloride salts 显示文摘 | Elena Gordo George Z Chen Derek J Fray | 2004 | Electrochimica Acta2004，49，： | 1 |
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