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| 1 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | Postinjury multiple organ failure显示文摘 | Dewar D Moore FA Moore EE | 2009 | Injury2009，40，4： | 1 |
| 3 | Bile acid and lysolecithin concentration in the stomach of patients with gastric ulcer显示文摘 | Dewar P King R Johnston D | 1983 | Br Jsurg1983，73，： | 1 |
| 4 | Postinjury multiple organ failure显示文摘 | Dewar D Moore FA Moore EE | 2009 | Injury2009，40，9： | 1 |
| 5 | The adoption of radical and incremental innovations:An empirical analysis显示文摘 | Dewar R D Dutton J E | | 0，，11： | 1 |
| 6 | The adoption of radical and incremental innovations:An empirical analysis显示文摘 | Dewar R D Dutton J E | 1984 | Management Science1984，30，： | 1 |
| 7 | The adoption of radical and incremental innovations an empirical analysis 显示文摘 | DEWAR R D DUTTON J E | 1986 | Man- agement science1986，32，11： | 1 |
| 8 | Quantitative assessment of ischemic pathology in axons, oligodendrocytes, and neurons: attenuation of damage after transient ischemia显示文摘 | Valeriani V Dewar D Mcculloch J | 2000 | J Cereb Blood Flow Metab2000，20，： | 1 |
| 9 | Legacy System Reengineering and Business Process:A Pattern Perspective显示文摘 | FLOYD A D DEWAR R POOLEY R | 1999 | Communications of the Association of Information Systems1999，2，： | 1 |
| 10 | The Adoption of Radical and Incremental Innovations: An Empirical Analysis 显示文摘 | DEWAR R D DUTTON J E | 1986 | Management Science1986，32，11： | 1 |
| 11 | A radical approach to sroke therapy显示文摘 | McCulloch J Dewar D | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 12 | The adoption of radical and incremental innovations: an empirical analysis显示文摘 | Dewar R D | 1986 | Management Science1986，32，11： | 1 |
| 13 | Drug development for stroke: impor- tance of protecting cerebral white matter显示文摘 | Dewar D Yam P McCulloch J | 1999 | Eur J Pharmacol1999，375，13： | 1 |
| 14 | Postinjury multiple organ failure显示文摘 | Dewar D Moore FA Moore EE | 2009 | Injury2009，40，9： | 1 |
| 15 | White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat显示文摘 | Mccracken E Dewar D Hunter A J | 2001 | Brain Res2001，892，2： | 1 |
| 16 | The adoption of radical and incremental innovation: An empirical analysis显示文摘 | Dewar R D Dutton J E | 1986 | Man- agement Science1986，32，11： | 1 |
| 17 | Bile acid and Lysolecithin concentration in the Stomach of patients with gastric ulcer ; before and after treatment by highly selective vagotomy:Billroth partial gastrectomy and truncal vagotomy and pylorlplasty显示文摘 | King R Johnston D | 1983 | Br J Surg1983，70，： | 1 |
| 18 | The Adoption of Radical and Incremental Innovations: An Empirical Analysis显示文摘 | Dewar R D DuttonJ E | 1986 | Management Science1986，32，11： | 1 |
| 19 | Depletion of choline acetyltransferase activity but preservation of M《,1》 and M《,2》 musearinic receptor binding sites in temporal cortex following head injury:a preliminary human postmortem study显示文摘 | Dewar D Graham DI | 1996 | J Neurotrauma1996，13，4： | 1 |
| 20 | Oligodendrocytes and ischemic brain injury显示文摘 | Dewar D Underhill SM Goldberg MP | 2003 | J Cereb Blood Flow Metab2003，23，3： | 1 |
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