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| 1 | Molecular mechanisms of coronavirus RNA capping and methylation显示文摘The 5′-cap structures of eukaryotic m RNAs are important for RNA stability, pre-m RNA splicing,m RNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2′-Oposition of the first nucleotide, which help viral RNAs escape recognition by the host innate immune system. The RNA genomes of coronavirus were identified to have 5′-caps in the early1980 s. However, for decades the RNA capping mechanisms of coronaviruses remained unknown.Since 2003, the outbreak of severe acute respiratory syndrome coronavirus has drawn increased attention and stimulated numerous studies on the molecular virology of coronaviruses. Here, we review the current understanding of the mechanisms adopted by coronaviruses to produce the 5′-cap structure and methylation modification of viral genomic RNAs. | Yu Chen Deyin Guo | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | PTEN-L promotes type I interferon responses and antiviral immunity显示文摘Phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human cancer.Our previous work has demonstrated that PTEN also plays a vital role in type I interferon responses and antiviral innate immunity.Recently,a translational variant of PTEN with a long N-terminal extension(PTEN-L)has been discovered that is secreted into the extracellular environment and enters recipient cells,where it exerts a phosphatase function antagonistic to PI3K/Akt signaling and tumorigenesis.In this study,we demonstrate that PTEN-L promotes type I interferon responses and antiviral innate immunity during viral infection in a phosphatase activity-dependent manner.Compared with canonical PTEN,PTEN-L also exerts its antiviral function when it is applied exogenously in protein form.This finding was confirmed in cell cultures and mouse infection models.Furthermore,PTEN-L enhances the responses of both type I interferon and proinflammatory cytokines,thus suggesting that PTEN-L might possess additional functions compared with those of PTEN.Thus,the antiviral function of PTEN-L may open an avenue for the use of PTEN-L in antiviral therapy,particularly in patients with PTEN-deficient tumors. | Yuanyuan Cao Hongyun Wang Liu Yang Zhen Zhang Chenlin Li Xu Yuan Lang Bu Lang Chen Yu Chen Chun-Mei Li Deyin Guo | 2018 | Cellular & Molecular Immunology2018，15，1： | 3 |
| 3 | Fabrication and performance of PET mesh enhanced cellulose acetate membranes for forward osmosis显示文摘Polyethylene terephthalate mesh(PET) enhanced cellulose acetate membranes were fabricated via a phase inversion process. The membrane fabrication parameters that may affect the membrane performance were systematically evaluated including the concentration and temperature of the casting polymer solution and the temperature and time of the evaporation, coagulation and annealing processes. The water permeability and reverse salt flux were measured in forward osmosis(FO) mode for determination of the optimal membrane fabrication conditions. The optimal FO membrane shows a typical asymmetric sandwich structure with a mean thickness of about 148.2 μm. The performance of the optimal FO membrane was tested using 0.2 mol/L Na Cl as the feed solution and 1.5 mol/L glucose as the draw solution. The membrane displayed a water flux of 3.47 L/(m2·hr) and salt rejection of95.48% in FO mode. While in pressure retarded osmosis(PRO) mode, the water flux was4.74 L/(m2·hr) and salt rejection 96.03%. The high ratio of water flux in FO mode to that in PRO mode indicates that the fabricated membrane has a lower degree of internal concentration polarization than comparable membranes. | Guoliang Li Jun Wang Deyin Hou Yu Bai Huijuan Liu | 2016 | Journal of Environmental Sciences2016，28，7： | 2 |
| 4 | Electron microscopy studies of the coronavirus ribonucleoprotein complex显示文摘 | Gui, Miao Liu, Xin Guo, Deyin Zhang, Zhen Yin, Chang-Cheng Chen, Yu Xiang, Ye | 2017 | Protein & Cell2017，8，3： | 2 |
| 5 | Adaptive sliding mode control of multi-agent relay tracking systems with disturbances显示文摘This paper studies the switching topologies and tracking agent replacements for a class of nonlinear multi-agent systems with external disturbances.In particular,it is assumed that a number of monitoring agents are randomly deployed in a two-dimensional space.The agents are committed to tracking any intrusion targets in this area.When one of the following agents exits tracking for some reasons,the agent closer to the target joins the tracking team to ensure the number of tracking agents does not change.In order to achieve the successful tracking of the target,this paper designs a sliding mode controller for the relay multi-agent system with tracking agent replacements.Furthermore,an adaptive law is proposed to estimate the upper bound of disturbance in the relay tracking process.Next,the stability of the overall system will be analysed by applying the multiple Lyapunov function method based on the average dwell time.Finally,the effectiveness of the tracking strategy is verified by numerical simulations. | Deyin Yu Lijing Dong Hao Yan | 2021 | Journal of Control and Decision2021，8，2： | 1 |
| 6 | The sumoylation of zinc‐fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity显示文摘 | Shuliang Chen Xiao Yu Quan Lei Lixin Ma Deyin Guo | 2013 | J Cell Biochem2013，，10： | 1 |
| 7 | Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc(and STAT) interactor显示文摘Severe acute respiratory syndrome coronavirus(SARS-Co V) encodes eight accessory proteins, the functions of which are not yet fully understood. SARS-Co V protein 6(P6) is one of the previously studied accessory proteins that have been documented to enhance viral replication and suppress host interferon(IFN) signaling pathways. Through yeast two-hybrid screening, we identified eight potential cellular P6-interacting proteins from a human spleen c DNA library. For further investigation, we targeted the IFN signaling pathway-mediating protein, N-Myc(and STAT) interactor(Nmi). Its interaction with P6 was confirmed within cells. The results showed that P6 can promote the ubiquitin-dependent proteosomal degradation of Nmi. This study revealed a new mechanism of SARS-Co V P6 in limiting the IFN signaling to promote SARS-Co V survival in host cells. | Weijia Cheng Shiyou Chen Ruiling Li Yu Chen Min Wang Deyin Guo | 2015 | Virologica Sinica2015，30，2： | 1 |
| 8 | A Fast Two-Stage Black-Box Deep Learning Network Attacking Method Based on Cross-Correlation显示文摘Deep learning networks are widely used in various systems that require classification.However,deep learning networks are vulnerable to adversarial attacks.The study on adversarial attacks plays an important role in defense.Black-box attacks require less knowledge about target models than white-box attacks do,which means black-box attacks are easier to launch and more valuable.However,the state-of-arts black-box attacks still suffer in low success rates and large visual distances between generative adversarial images and original images.This paper proposes a kind of fast black-box attack based on the cross-correlation(FBACC)method.The attack is carried out in two stages.In the first stage,an adversarial image,which would be missclassified as the target label,is generated by using gradient descending learning.By far the image may look a lot different than the original one.Then,in the second stage,visual quality keeps getting improved on the condition that the label keeps being missclassified.By using the cross-correlation method,the error of the smooth region is ignored,and the number of iterations is reduced.Compared with the proposed black-box adversarial attack methods,FBACC achieves a better fooling rate and fewer iterations.When attacking LeNet5 and AlexNet respectively,the fooling rates are 100%and 89.56%.When attacking them at the same time,the fooling rate is 69.78%.FBACC method also provides a new adversarial attack method for the study of defense against adversarial attacks. | Deyin Li Mingzhi Cheng Yu Yang Min Lei Linfeng Shen | 2020 | Computers, Materials & Continua2020，，7： | 0 |
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