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| 1 | 最新治疗可延迟艾森门格综合征患者需要移植的时间显示文摘Aims: Advanced therapies(prostacyclin analogues, endothelin receptor antagonists) are successfully used in the treatment of idiopathic pulmonary arterial hypertension. In addition, patients with the Eisenmenger syndrome(ES) seem to benefit from these news drugs regarding symptoms, but there is still no evidence for changes in outcome. Methods and results: The clinical course of 43 patients(M/F 13/30, age 34.0±12.7 years), registered with unstable ES in our database, was retrospectively analysed. These patients were divided into two groups: those treated with and those treated without advanced therapy. The primary endpoint was defined as death from any cause. Death or inscription on the active waiting list of heart-lung transplantation was considered as secondary endpoint. Kaplan-Meier survival and log rank testing were performed to determine differences in outcome between the two groups. The total cohort was followed for a median period of 4.9(range 0.2-14.9) years. Mean survival time for patients treated with(n=26) and without(n=17) advanced therapy therapies were 8.5±1.5 and 8.5±0.9 years, respectively(log rank testing, P=0.31). However, the mean time to death or inscription on the active waiting list was significantly longer for patients treated with advanced therapy when compared with those without(7.8±1.0 vs. 3.4±0.9 years, P=0.006). Conclusion: For the given follow-up period, no improvement in survival time could be documented in adult patients with unstable ES treated with advanced therapy. However, we might suggest with these data that the need for heart-lung transplantation can be substantially delayed with new drugs. | Adriaenssens T. Delcroix M. Van Deyk K. Budts W. 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 2 | Percutaneous closure of a patent foramen ovale: single-centre experience using different types of devices and midterm outcome显示文摘 | Post MC Van Deyk K Budts W | 2005 | J Acta Cardiol2005，60，5： | 1 |
| 3 | Individual quality of life in adults with congenital heart disease:a paradigm shift显示文摘 | Moons P Van Deyk K Marquet K | 2005 | Eur Heart J2005，26，3： | 1 |
| 4 | Patient knowledge ofand adherence to oral anticoagulation therapy after mechanicalheart - valve replacement for congenital or acquired valve defects显示文摘 | Van Damme S Van Deyk K Budts W | 2011 | Heart Lung2011，40，： | 1 |
| 5 | Patient knowledge of and adherence to oral anticoagulation therapy after mechanical heart-valve replacement foreongenital or acquired valve defects 显示文摘 | Van Damme S Van Deyk K Budts W | 2011 | Heart Lung2011，40，2： | 1 |
| 6 | Patient knowledge of and adherence to oral anticoagulation therapy after mechanical heart-valve replacement for congenital or acquired valve defects显示文摘 | Sara Van Damme Kristien Van Deyk Werner Budts Peter Verhamme Philip Moons | 2011 | Heart & Lung - The Journal of Acute and Critical Care2011，，2： | 1 |
| 7 | Prevention of stroke by percutaneous left atrial appendage closure: short term follow-up 显示文摘 | De Meester P Thijs V Van Deyk K | 2010 | Int J Cardiol2010，142，2： | 1 |
| 8 | Repair for partial and complete atrioventricular septal defect: single centre experience and long-term results显示文摘 | Souffiet V Daenen W Van Deyk K | 2005 | Acta Clin Belg2005，60，5： | 1 |
| 9 | Behavior of Ebstein′s anomaly:single-center experience and midterm follow-up显示文摘 | Tegius B van De Bruaene A van Deyk K | 2010 | Cardiology2010，17，2： | 1 |
| 10 | Patient knowledge of and adherence to oral anticoagulation ther- apy after mechanical heart-valve replacement forcongeni- tal or acquired valve defects显示文摘 | Van Damme S Van Deyk K Budts W | 2011 | Heart Lung2011，40，2： | 1 |
| 11 | The future of adult patients after Mustard or Senning repair for transposition of the great arteries显示文摘 | Werner Budts Chris Scheurwegs An Stevens Philip Moons Kristien Van Deyk Luc Vanhees | 2005 | International Journal of Cardiology2005，，2： | 1 |
| 12 | Patient knowledge of and adherence to oral anticoagulation therapy after mechanical heart-valve replacement for congenital or acquired valve defects显示文摘 | Van Damme S Van Deyk K Budts W | 2011 | Heart Lung2011，40，2： | 1 |
| 13 | Individual quality of life in adults with congenital heart disease: a paradigm shift显示文摘 | Moons P Van Deyk K Marquet K | 2005 | Eur Heart J2005，26，： | 1 |
| 14 | Behavior of Ebstein's anomaly:single-center experience and midterm follow-up显示文摘 | Leqius B Van De Bruaene A Van Deyk K | | 0，，02： | 1 |
| 15 | Profile of adults with congenital heart disease having a good, moderate, or poor quality of life: a cluster analytic study显示文摘 | Moons P Van Deyk K Marquet K | 2009 | Eur J Cardiovasc Nurs2009，8，： | 1 |
| 16 | Behavior of Eb- stein' s anomaly: single-center experience and midterm follow-up 显示文摘 | Leqius B van De Bruaene A van Deyk K | 2010 | Cariology2010，117，2： | 1 |
| 17 | Individual quality of life in adults with congenital heart disease: a paradigm shift 显示文摘 | Moons P Van Deyk K Marquet K | 2005 | Fur Heart J2005，26，3： | 1 |
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