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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Targeting angiogenic processes by combination rofecoxib and ionizing radiation显示文摘 | Dicker AP Williams TL Grant DS | 2001 | Am J Clin Oncol2001，24，： | 1 |
| 3 | Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade(bortezomib,PS-341)显示文摘 | Kamer S Ren Q Dicker AP | 2009 | Arch Gynecol Obstet2009，279，1： | 1 |
| 4 | Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade (bortezomib,PS-341)显示文摘 | Kamer S Ren Q Dicker AP | 2009 | Arch Gynecol Obstet2009，279，1： | 1 |
| 5 | Microsugical Inguinal Varicocelectomy with Delivery of the Testis: an artery and lymphatic sparing technigue 显示文摘 | Goldstein M Gibert BR Dicker AP | 1992 | J Urol1992，148，6： | 1 |
| 6 | The meaning of p16(ink4a)expression in tumors:functional significance,clinical associations and future developments显示文摘 | Witkiewicz AK Knudsen KE Dicker AP | 2011 | Cell Cycle2011，10，15： | 1 |
| 7 | Differential radiation sensitiza?tion of human cervical cancer cell lines by the proteasome in?hibitor velcade (bortezomib, PS- 341)显示文摘 | Kamer S Ren Q Dicker AP | 2009 | Arch Gynecol Ob?stet2009，279，： | 1 |
| 8 | Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary results 显示文摘 | Forsberg F Dicker AP Thakur ML | 2002 | Ultrasound Med Biol2002，28，4： | 1 |
| 9 | lnhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis 显示文摘 | Kater AP Dicker F Mangiola M | 2005 | Blood2005，106，5： | 1 |
| 10 | Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents:exploring mechanisms of interaction显示文摘 | Wachsberger P Burd R Dicker AP | | 0，，06： | 1 |
| 11 | Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: Preliminary results显示文摘 | Forsberg F Dicker AP Thakur ML | 2002 | UItrasound Med Biol2002，28，4： | 1 |
| 12 | Comparing con- trast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: prelimi- nary results 显示文摘 | Forsberg F Dicker AP Thakur ML | 2002 | Ultrasound Med Biol2002，28，4： | 1 |
| 13 | Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents:exploring mechanisms of interaction显示文摘 | Wachsberger P Burd R Dicker AP | 2003 | Clin Cancer Res2003，9，6： | 1 |
| 14 | Microsurgical inguinal varicocelectomy with delivery of the testis : an artery and lymphatic sparing technique显示文摘 | Goldstein M Gilbert BR Dicker AP | 1992 | J Urol1992，148，6： | 1 |
| 15 | Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction显示文摘 | Wachsberger P Burd R Dicker AP | 2003 | Clin Cancer Res2003，9，6： | 1 |
| 16 | Assessment of epidermal growth factor receptor (EGFR) expression in human meningioma 显示文摘 | Wemicke AG Dicker AP Whiton M | 2010 | Radiation Oncology2010，5，： | 1 |
| 17 | Biologically conformal treatment: biomarkers and functional imaging in radiation oncology 显示文摘 | Lawrence YR Werner-Wasik M Dicker AP | 2008 | Future Oncnl2008，4，5： | 1 |
| 18 | Microsurgical inguinal varicoeeleetomy with delivery of the testis an artery and lymphatic sparing technique显示文摘 | Goldstein M Gilbert BR Dicker AP | 1992 | J Urol1992，148，6： | 1 |
| 19 | Tumor response to ionizing radiationcombined Burd with antiangiogenesis or vascular targeting agents:exploring mechanisms of interaction显示文摘 | Wachsberger PR Dicker AP | | 0，，06： | 1 |
| 20 | Comparing contrast-enhanced ultrasound to immunohlstochemical markers of angiogenesis in a human melanoma xenograft model: Preliminary results显示文摘 | Forsberg F Dicker AP Thakur ML | 2002 | Ultrasound Med Biol2002，28，4： | 1 |
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