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27篇 您的检索式:作者名="Dighe A S"
    题名 作者 年代 出处 被引量
1A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA.Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui 2016Bone Research2016,4,2:7
2Analysis of laboratory critical value reporting at a large academic medical center 显示文摘Dighe A S Rao A Coakley A B 2006Am J Clin Pathol2006,125,:1
3Analysis of labo- ratory critical value reporting at a large academic medical center显示文摘Dighe A S Rao A Coakley A B 2006Am J Clin Pathol2006,125,5:1
4Analysis of transmit-receive diversity in Rayleigh fading显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,4:1
5Regulation of the interleukin (IL)-12R beta 2 subunit expression in devdoping T helper 1 (Th1) and Th2 cells显示文摘Szabo S J Dighe A S Gubler U 1997J Exp Med1997,185,5:1
6Analysis of laboratory criti- cal value reporting at a large academic nledicalcenter显示文摘Dighe A S Rao A Coakley A B eta! 2006American Journal of Clinical Pathology''2006,125,5:1
7Analysis of Transmit-receive Diversity in Rayleigh Fading 显示文摘Dighe P A Mallik P K Jamuar S S 2003IEEE Transacations on Communications2003,51,4:1
8Computerized provider order entry in the clinical laboratory显示文摘Baron J M Dighe A S 2011J Pathol Inform2011,,2:1
9Analysis of laboratory critical value reporting at a large academic medical center显示文摘Dighe A S Rao A Coakley AB 2006Am J Clin Pathol2006,125,:1
10Analysis of transmit- receive diversity in Rayleigh fading显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,6:1
11Analysis of transmit-receive diversity in Rayleigh fading 显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,4:1
12Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway显示文摘Meraz M A White J M Sheehan K C Bach E A Rodig S J Dighe A S Kaplan D H Riley J K Greenlund A C Campbell D Carver-Moore K DuBois R N Clark R Aguet M Schreiber R D 0,,3:1
13Regulation of the interleukin (IL) -12R beta 2 subunit expression in develo- pingT helper 1 (Thl) and Th2 cells显示文摘Szabo S J Dighe A S Gubler U 1997J Exp Med1997,185,5:1
14Combined angiogenic and osteogenicfactor delivery for bone regenerative engineering显示文摘CUI Q DIGHE A S IRVINE J J 2013CurrPharm Des2013,19,19:1
15Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice显示文摘DIGHE A S KAPLAN D H SHANKARAN V 1998Proc Natl Acad Sci U S A1998,95,13:1
16Analysis of transmit-receive diversity in Rayleigh fading显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,4:1
17Analysis of laboratory critical value reporting at a large academic medical center显示文摘Dighe A S Rao A Coakley A B etal 2006Am J Clin Pathol2006,125,:1
18Analysis of transmit-receive diversity in Rayleigh fading显示文摘Dighe P A Mallik R K and Jamuar S S 2003IEEE ansactions on Communications2003,51,4:1
19Analysis of transmit-receive diversity in Raleigh fading显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,4:1
20Regulation of the interleukin (IL) 12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells显示文摘SZABO S J DIGHE A S GULBER U 1997J Erp Med1997,185,5:1
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