|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 新辅助免疫治疗可以为MMR表达以及MMR缺失型早期结肠癌患者带来病理缓解显示文摘PD-1联合CTLA-4阻滞剂对晚期错配修复蛋白(MMR)缺失(dMMR)型结直肠癌患者的治疗非常有效,但对MMR表达(pMMR)的患者无效。我们假设在早期结肠癌患者中新辅助免疫疗法具有更好的疗效。在探索性NICHE研究中(Clinical Trials.gov:NCT03026140),dMMR或pMMR患者在手术前接受单剂量伊匹单抗(ipilimumab)和两剂量纳武单抗(nivolumab)治疗,pMMR患者联合或者不联合使用塞来昔布。本研究的主要观察指标是安全性和可行性。在纳入分析的40例患者中,包括21例dMMR患者和19例pMMR患者,他们均接受了治疗,其中3例经安全性讨论后仅接受了纳武单抗单药治疗。患者治疗耐受性良好,所有患者均接受了根治性切除且未延期进行,符合主要观察指标的观察预期。在接受伊匹单抗+纳武单抗治疗的患者(20例dMMR患者和15例pMMR患者)中,共35例可进行疗效和转化效果评估。在20例dMMR患者中,病理缓解率为100%(95%CI:86%~100%),有19例患者达到主要病理缓解(MPRs,残留存活肿瘤≤10%),其中包括12例患者达到完全病理缓解。在15例pMMR患者中,有4例达到病理缓解,其中包括3例主要病理缓解和1例部分缓解。CD8+PD-1+T细胞浸润情况可预测pMMR患者的治疗应答。基于这些数据认为,如果新辅助免疫治疗效果能被基于至少3年无病生存数据的更加大型的临床研究结果支持,那么其则有望作为特定结肠癌患者的标准治疗方案。 | 张荣欣 CHALABI M FANCHI L F DIJKSTRA K K | 2020 | 结直肠肛门外科2020，26，6： | 87 |
| 2 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 3 | cd显示文摘 | Nardini M Dijkstra B W | 1999 | Current Opinion in Structural Biology1999，9，： | 1 |
| 4 | Kinetics and mechanism of L - lactide polymerization using two different yttrium alkoxides as initiators 显示文摘 | Stevels W M Ankone M J K Dijkstra P J | 1996 | Macromolecules1996，29，： | 1 |
| 5 | Glutaraldehyde as a crosslinking agent for collagen-based biomaterials 显示文摘 | Damink L H H O Dijkstra P J Van Luyn M J | 1995 | Journal of Materials Science: Materials in Medicine1995，8，6： | 1 |
| 6 | Recent clinical developments in pathophysiology,epidemiology,diagnosis and treatment of intra abdominal adhesions显示文摘 | Dijkstra FR Nieuwenhuijzen M Keijnen MM | 2000 | Scand J Gastroenterol Suppl2000，232，35： | 1 |
| 7 | Kinetic and spectral studies on the redox forms of methanol dehydrogenase from Hyphomicrobium X显示文摘 | FRANK J JR DIjKSTRA M DUINE JA | 1988 | Eur J Biochem1988，174，2： | 1 |
| 8 | Assessment of oral mueositis in clinical trials:impact of lraining on evaluators in a multi-centre trial 显示文摘 | Stokman M A Sonis S T Dijkstra P U | 2005 | Eur J Cancer2005，41，12： | 1 |
| 9 | Bacterial biocatalysis:Molecular biology,three-dimensional structures,and biotechnological applications of lipases显示文摘 | Jaeger K-E Dijkstra B W Reetz M T | 1999 | Annual Review of Microbiology1999，53，1： | 1 |
| 10 | Statistical evaluation of mathematical models for microbial growth Intematonal显示文摘 | S Lopez M prieto J Dijkstra | 2004 | Jourmal of Food Microbiology2004，96，： | 1 |
| 11 | Health and nursing problems of elderly patients related to bio-psycho-social need deficiencies and functionalassessment显示文摘 | Muszalik M Dijkstra A Kedziora-Kornatowska K | 2012 | Arch Gerontol Geriatr2012，55，1： | 1 |
| 12 | Therapy-re- sistant complex regional pain syndrome type Ⅰ , to amputate or not? 显示文摘 | Bodde M I Dijkstra P U den Dunnen W F | 2011 | J Bone Joint Surg Am2011，93，19： | 1 |
| 13 | Percutaneous ver- tebroplasty in very severe osteoporotic vertebral compression fractures: feasible and beneficial显示文摘 | Nieuwenhuijse M J van Erkel AR Dijkstra PD | 2011 | J Vasc Interv Radiol2011，22，7： | 1 |
| 14 | Recent clinical developments in pathophysiology, epidemiology, diag- nosis and treatment of intra-abdominal adhesions 显示文摘 | Dijkstra FR Nieuwenhuijzen M Reijnen MM | 2000 | Seand J Gastroenterol Suppl2000，，232： | 1 |
| 15 | MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia显示文摘 | Jongen-Lavrencic M Sun SM Dijkstra MK | 2008 | Blood2008，111，10： | 1 |
| 16 | Sea- sonal Variation in the Dutch Bovine Raw Milk Composition显示文摘 | HECK J M L VAN VALENBERG H J F DIJKSTRA J | 2009 | Jour- nal of Dairy Science2009，92，10： | 1 |
| 17 | miRNA analysis in B-cell chronic lymphocytic leukemia:proliferation centres characterized by low miR-150 and high BIC/miR-155expression显示文摘 | Wang M Tan L P Dijkstra M K | 2008 | J Pathol2008，215，： | 1 |
| 18 | Thermosensitive micelle-forming block copolymers of poly ( ethylene glycol ) and poly ( N-isopropylacrylamide) 显示文摘 | Topp M D C Dijkstra P J | 1997 | Macromolecules1997，30，： | 1 |
| 19 | Multiple sclerosis and vitamin D:an update显示文摘 | VanAmerongen B M Dijkstra C D Lips P | 2004 | Eur J Clin Nutr2004，58，8： | 1 |
| 20 | Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD显示文摘 | Dijkstra AE Boezen HM van den Berge M | 2015 | Eur RespirJ2015，45，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员