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| 1 | Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs显示文摘 | Floriane Pez Ana?s Lopez Miran Kim Jack R. Wands Claude Caron de Fromentel Philippe Merle | 2013 | Journal of Hepatology2013，，： | 3 |
| 2 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 4 | Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder显示文摘 | Alicia Flausse Christel Henrionnet Manuel Dossot Dominique Dumas Sébastien Hupont Astrid Pinzano Didier Mainard Laurent Galois Jacques Magdalou Evelyne Lopez Pierre Gillet Marthe Rousseau | 2013 | J. Biomed. Mater. Res2013，，11： | 2 |
| 5 | Activation of the hepatic LDL receptor promoter by thyroid hormone显示文摘 | Dayami Lopez Jose F. Abisambra Socarrás Mohini Bedi Gene C. Ness | 2007 | BBA - Molecular and Cell Biology of Lipids2007，，9： | 2 |
| 6 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 7 | Examining the relationship between executive functions and restricted, repetitive symptoms of autistic disorder 显示文摘 | Lopez BR Lincoln AJ Ozonoff S | 2005 | Journal of Autism & Developmental Disorders2005，35，4： | 1 |
| 8 | Renal and perirenal abscess显示文摘 | Lopez Alcina E Arlandis Guzman S Monserrat Monfort JJ | 1999 | Actas Urol Esp1999，23，2： | 1 |
| 9 | New Cytotoxic Indolic Metabolites from a Marine Streptomyces显示文摘 | Jose M Lopez S Jensen PR | 2003 | J Nat Prod2003，66，： | 1 |
| 10 | Phytoplankton and Zooplankton Response to Ultraviolet Radiation in a High-Altitude Andean Lake:Short-Versus Long-Term Effects显示文摘 | Cabrera S Lopez M Tartarotti B | 1997 | Journal of Plankton Research1997，19，： | 1 |
| 11 | Determination of nitrofuran residues in milk of dairy cows using liquid chromatography-tandem mass spectromeU'y显示文摘 | CHU P S LOPEZ M I | 2007 | J Agric Food Chem2007，55，6： | 1 |
| 12 | Cholinergic afferents to the locus coeruleus and noradrenergic afferents to the medial septum mediate LTP - reinforcement in the dentate gyms by stimulation of the amyg- dale显示文摘 | Bergado JA Frey S Lopez J | 2007 | Neurobiol Learn Mem2007，88，： | 1 |
| 13 | Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study显示文摘 | Douglas S Berkman Andres G Lescano Robert H Gilman Sonia L Lopez Maureen M Black | 2002 | The Lancet2002，，9306： | 1 |
| 14 | Scarlet fever outbreak in a public school in Granada in 2012显示文摘 | FERNNDEZ-PRADA M MART COLINA LOPEZ A | 2014 | An Pedialr (Barc)2014，80，4： | 1 |
| 15 | Osmotic response in Lactobacillus casei ATCC 393:biochemical and biophysical characteristics of membrane显示文摘 | Machado M C Lopez C S Heras H | 2004 | Arch Biochem Biophy2004，422，： | 1 |
| 16 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCl solution显示文摘 | Vanessa Vasconcelos Torres Roberto Salgado Amado Camila Faia de Sá Tatiana Lopez Fernandez Carlos Alberto da Silva Riehl Alexandre Guedes Torres Eliane D’Elia | 2011 | Corrosion Science2011，，7： | 1 |
| 17 | Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis 显示文摘 | Mokdad A A Lopez A D Shahraz S | 2014 | Bmc Medicine2014，12，1： | 1 |
| 18 | Colloidal microgels as transdermal delivery systems显示文摘 | Lopez V C Raghavan S L Snowden M J | 2004 | React Funct Polym2004，58，3： | 1 |
| 19 | of wear resistant high chromium, high carbon cast irons显示文摘 | Maldonado-ruiz S I lopez Mierostruetural evaluation D Velasco A Colas R | 2004 | Material Science and Technology2004，20，3： | 1 |
| 20 | Automatic design and optimization of wind turbine blades显示文摘 | Díaz Casás V Lopez Pea F Duro R J | 2006 | Computer Society2006，，1： | 1 |
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