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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference显示文摘 | Rubinson D A Dillon C P Kwiatkowski A V | 2003 | Nat Genet2003，33，3： | 1 |
| 3 | Alentivirus-based system to functionally silence genes in primarymammalian cells, stem cells and transgenic mice by RNAinterference 显示文摘 | Rubinson D A Dillon C P Kwiatkowski A J | 2003 | Nat Genet2003，33，3： | 1 |
| 4 | Separation and charac- terization of Nom by high - performance liquid chromatography and on - line three - dimensional excitation emission matrix fluo- rescence detection 显示文摘 | Wu F C Evans R D Dillon P J | 2003 | Environmental Science & Technology2003，37，16： | 1 |
| 5 | Metal oxide nano-particles for improved electrochromic and lithium battery technologies显示文摘 | DILLON A C MAHAN A H DESHPANDE R PARILLA P A JONES K M LEE K H | 2008 | Thin Solid Films2008，516，： | 1 |
| 6 | A Lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference显示文摘 | Rubinson D A Dillon C P Kwiatkowski A V | 2003 | Nat Genet2003，33，3： | 1 |
| 7 | The first true inorganic fullerenes?显示文摘 | Parilla P A Dillon A C Jones K M | 1999 | Nature1999，397，： | 1 |
| 8 | A lentivirus-based system to functionally silence genes in primary mammalian cells,stem cells and transgenic mice by RNA interference显示文摘 | Rubinson D A Dillon C P Kwiatkowski A V | 2003 | Nat Genet2003，33，3： | 1 |
| 9 | Cre-lox-regulated conditional RNA interference from transgenes显示文摘 | Ventura A Meissner A Dillon C P | 2004 | Proc Nati Acad Sci2004，101，10： | 1 |
| 10 | Variable-density modeling of multiple-cycle aquifer storage and recovery (ASR):importance of anisotropy and layered heterogeneity in brackish aquifers显示文摘 | WARD J D SIMMONS C T DILLON P J | | 0，，06： | 1 |
| 11 | Eft~ct of load shape on relationship between dissipated energy and resid-ual excess pore pressure generation in cyclic triaxial tests 显示文摘 | POLITO C P GREEN R A DILLON E | 2013 | Canadian Geotechnical Journal2013，50，11： | 1 |
| 12 | Mitoehondrial DNA transcription regulation and nucleoid organiza- tion显示文摘 | Rebelo A P Dillon L M Moraes C T | 2011 | Journal of inherited metabolic disease2011，34，4： | 1 |
| 13 | Mechanism of apoptosis induction by inhibition of the anti-apoptotic Bcl-2 proteins 显示文摘 | Jerry E Chipuk John C Fisher Christopher P Dillon | 2008 | Nat Acad Sci USA2008，105，20： | 1 |
| 14 | A lentivirus-based system to functionally silence genes in primary mammalian cells,stem cells and transgenic mice by RNA interference显示文摘 | Rubinson D A Dillon C P Kwiatkowski A V | 2003 | Nature Genetics2003，33，： | 1 |
| 15 | 显示文摘 | Hornyak G L Dillon A C Parilla P A | 1999 | Nanostructured Materials1999，12，： | 1 |
| 16 | Separation and characterization of NOM by high-performance liquid chromatography and on-line three-dimensional excitation emission matrix fluorescence detection 显示文摘 | WU F C EVANS R D DILLON P J | 2003 | Environmental Science & Technology2003，37，： | 1 |
| 17 | The first true inorganic fullerenes?显示文摘 | DILLON A C JONES K M | 1999 | Nature1999，397，6715： | 1 |
| 18 | Acute toxicity ofcadmium,lead,zinc,and their mixtures to stream-resident fishand invertebrates 显示文摘 | Mebane C A Dillon F S Hennessy D P | 2012 | Environmental Toxicology and Chemistry2012，31，6： | 1 |
| 19 | A theoretic- cal analysis of mixed convection in aquifer storage and recovery: How important are density effects?显示文摘 | WARD J D SIMMONS C T DILLON P J | 2007 | Journal of Hydrology2007，343，3： | 1 |
| 20 | A lentivir- us-based system to functionally silence genes in primary mamma- lian cells, stem cells and transgenic mice by RNA interference显示文摘 | Rubinson D A Dillon C P Kwialkowski A V | 2003 | Nat Genet2003，33，： | 1 |
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