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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | SELECTIVE DIMERIZATION OF BUTANAL TO BUTYL BUTYRATE CATALYZED BY LANTHANOCENE/n-BuLi SYSTEMS显示文摘SELECTIVEDIMERIZATIONOFBUTANALTOBUTYLBUTYRATECATALYZEDBYLANTHANOCENE/n-BuLiSYSTEMS￥FanXU,LiLuZHANG,MingYAO,YuanChenDING,ZhiMi... | Xu, F Zhang, LL Yao, YM Ding, YC Bai, ZM Shen, Q | 1995 | Chinese Chemical Letters1995，6，7： | 2 |
| 3 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | J Phys Chem B2000，104，19： | 1 |
| 4 | Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopausal women显示文摘 | Ding Q F Hayashi T Zhang X J | 2007 | J Diabetes Complications2007，21，5： | 1 |
| 5 | Simulation of stationary Gaussian stochastic wind velocity field显示文摘 | Ding Q S Zhu L D Xiang H F | 2006 | Wind and Structures2006，9，3： | 1 |
| 6 | Biomacromolecules显示文摘 | Chen Y Ding D Mao Z Q He Y F Hu Y Wu W Jiang X Q | 2008 | 9(10):2609-26142008，9，10： | 1 |
| 7 | Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats 显示文摘 | Ding Y F Brower G L Zhong Q | 2008 | Clin Exp Pharmacol Physiol2008，35，7： | 1 |
| 8 | Drug use evaluation of cefepime in the first affiliated hospital of Bengbu medical college: a retrospective and prospective analysis显示文摘 | Shi Q Ding F Sang R | 2013 | BMC Infect Dis2013，13，： | 1 |
| 9 | Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide aynthase for naphthoate biosynthesis 显示文摘 | Zhao Q F He Q L Ding W | 2008 | Chem Biol2008，15，1： | 1 |
| 10 | Shrimp zircon geochronological and geochemical evidence for Neo - Proterozoic arc - related magmatism along the western of the Yangtze Block, South China 显示文摘 | Zhou M F Yah D P Kennedy A K Li Q I and Ding J | 2002 | Earth Planet Sci Lett2002，196，： | 1 |
| 11 | Separation and determination of three phenylpropanoids in the traditional Chinese medicine and its preparations by capillary electrophoresis显示文摘 | Li F Cao Q Ding Z T | 2007 | J Chromatogr Sci2007，45，14： | 1 |
| 12 | Combustion synthesis of graphene oxide-TiO2 hybrid materials for photodegradation of methyl orange 显示文摘 | Gao Y Y Pu X P Zhang D F Ding G Q Shao X Ma J | 2012 | Carbon2012，50，： | 1 |
| 13 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | JPhys Chem B2000，104，19： | 1 |
| 14 | Coupled buffeting response analysis of long-span bridges by the CQC approach 显示文摘 | Ding Q S Chen A R Xiang H F | 2002 | Structural Engineering and Mechanics2002，14，5： | 1 |
| 15 | Electrochromic properties of ZnO thin films prep ared by pulsed laser deposition 显示文摘 | Fu Z W Qin Q Z | 1999 | Electrochem Solid-State Lett1999，2，8： | 1 |
| 16 | High-response elec-tromagnetic actuator with twisting axis for gravure sys-tems显示文摘 | FANG P DING F LI Q P | 2009 | IEEE Transactions on Magnetics2009，45，1： | 1 |
| 17 | 显示文摘 | Li Q Ding D Li F | 2002 | J Crystal Growth2002，236，： | 1 |
| 18 | N546 in 1318 1319 loop is important for binding and toxicity of the Bacillus thuringiensis CrylAc toxin显示文摘 | Wang F X Xia L Q Ding X Z | 2009 | Journal of Invertebrate Pathology2009，101，2： | 1 |
| 19 | Fatigue damage variable and evolution of rock subjected to cyclic load- ing显示文摘 | Xiao J Q Ding D X Jiang F L | 2010 | International Journal of Rock Mechanics and Mining Sciences2010，47，3： | 1 |
| 20 | Microstructure and corrosion resistance of phytic acid conversion coatings for magnesium alloy 显示文摘 | CUI X LI Q LI Y WANG F JIN G DING M | 2008 | Applied Surface Science2008，255，： | 1 |
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