3篇
您的检索式：作者名="Ding Songwei"
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| 1 | Detection and identification of 12-lead synchronous EGG waveform显示文摘 | Ning Xinbao Li Dehua Ding Songwei | 2004 | Journal of Nanjing University:Natural Sciences2004，40，1： | 1 |
| 2 | Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system显示文摘The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy(PDT).Hence,in this study,indocyanine green(ICG)-loaded lipid-coated zinc peroxide(ZnO_(2))nanoparticles(ZnO_(2)@Lip-ICG)was constructed to realize tumour microenvironment(TME)-responsive self-oxygen supply.Near infrared light irradiation(808 nm),the lipid outer layer of ICG acquires sufficient energy to produce heat,thereby elevating the localised temperature,which results in accelerated ZnO_(2)release and apoptosis of tumour cells.The ZnO_(2)rapidly generates O_(2)in the TME(pH 6.5),which alleviates tumour hypoxia and then enhances the PDT effect of ICG.These results demonstrate that ZnO_(2)@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics,and thus,achieve good tumour proliferation suppression. | Nan Wu Yaqin Tu Guorun Fan Jiahui Ding Jun Luo Wei Wang Chong Zhang Caiyan Yuan Handan Zhang Pei Chen Songwei Tan Hongjun Xiao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 0 |
| 3 | Co-delivery of luteolin and TGF-β1 plasmids with ROS-responsive virus-inspired nanoparticles for microenvironment regulation and chemo-gene therapy of intervertebral disc degeneration显示文摘Intervertebral disc degeneration(IDD)is closely related to inflammation and imbalance of synthesis/catabolism of extracellular matrix(ECM)in intervertebral disc(IVD).Considering this,luteolin(LUT),a kind of natural flavonoid with good anti-inflammatory effect and TGF-β1(a gene that promotes the regeneration of ECM)plasmid was co-loaded and co-delivered to nucleus pulposus cells(NPCs).Reactive oxygen species(ROS)responsive cationic copolymer,poly(β-amino ester)-poly(ε-caprolactone)(PBC),with high plasmid DNA(pDNA)compression affinity was synthesized.It can self-assemble into nano-sized polyplexes(pDNA@PBC)with virus-inspired structure and function through which it can transfect pDNA into NPCs with very high efficiency and negligible cytotoxicity.LUT was encapsulated in the hydrophobic core of pDNA@PBC.The co-delivery system,LUT-pTGFβ1@PBC,could enhance the cellular uptake of NPCs and manifest excellent sustained drug release in IVD.Real time quantitative polymerase chain reaction(RT-qPCR)and Western blot experiments reveal that the co-delivery system could inhibit inflammation in NPCs and restore the balance of anabolism and catabolism in vitro by activating TGF/SMAD3 and inhibiting NFkB/p65.Moreover,LUT-pTGF-β1@PBC retards IDD in vivo as detected by radiological and histological methods with good biosafety in rats.LUT-pTGF-β1@PBC may be a promising option for the treatment of IDD. | Yifan Ding Huan Wang Yunyun Wang Long Li Jiahui Ding Caiyan Yuan Tao Xu Haoran Xu Hui Xie Ning Zhu Xin Hu Huang Fang Songwei Tan | 2022 | Nano Research2022，15，9： | 0 |
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