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| 1 | Population dynamics of cancer cells with cell state conversions显示文摘 | Da Zhou Dingming Wu Zhe Li Minping Qian Michael Q. Zhang | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，3： | 6 |
| 2 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts显示文摘The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch.Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis. | Ling Ye Feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen Bo Gao Dingming Huang Peng Liu | 2018 | Bone Research2018，6，4： | 3 |
| 3 | Efficient retrieval of the top-k most relevant spatial Web objects 显示文摘 | Cong G Jensen C S Wu Dingming | 2009 | Proceedings of the VLDB Endowment2009，2，1： | 1 |
| 4 | 1994, A Continuously and Healthfully Developing Year for CNPC显示文摘1994,AContinuouslyandHealthfullyDevelopingYearforCNPCXuDingmingandWuFengshuo(PlanningBureau,CNPC)Keywords:Commodity,Explorati... | Xu Dingming and Wu Fengshuo(Planning Bureau,CNPC) | 1995 | China Oil & Gas1995，2，1： | 0 |
| 5 | Survey of Distributed Computing Frameworks for Supporting Big Data Analysis显示文摘Distributed computing frameworks are the fundamental component of distributed computing systems.They provide an essential way to support the efficient processing of big data on clusters or cloud.The size of big data increases at a pace that is faster than the increase in the big data processing capacity of clusters.Thus,distributed computing frameworks based on the MapReduce computing model are not adequate to support big data analysis tasks which often require running complex analytical algorithms on extremely big data sets in terabytes.In performing such tasks,these frameworks face three challenges:computational inefficiency due to high I/O and communication costs,non-scalability to big data due to memory limit,and limited analytical algorithms because many serial algorithms cannot be implemented in the MapReduce programming model.New distributed computing frameworks need to be developed to conquer these challenges.In this paper,we review MapReduce-type distributed computing frameworks that are currently used in handling big data and discuss their problems when conducting big data analysis.In addition,we present a non-MapReduce distributed computing framework that has the potential to overcome big data analysis challenges. | Xudong Sun Yulin He Dingming Wu Joshua Zhexue Huang | 2023 | Big Data Mining and Analytics2023，6，2： | 0 |
| 6 | Expert consensus on difficulty assessment of endodontic therapy显示文摘Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics. | Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou | 2024 | International Journal of Oral Science2024，16，1： | 0 |
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