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您的检索式：作者名="Domenick Zero"
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| 1 | Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface显示文摘To investigate how the biofilm three-dimensional(3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy. The enamel surface and mineral content characteristics were examined successively via optical profilometry and microradiography analyses. Sucrose-mediated biofilm formation created spatial heterogeneities manifested by complex networks of bacterial clusters(microcolonies). Acidic regions(pH<5.5) were found only in the interior of microcolonies,which impedes rapid neutralization(taking more than 120 min for neutralization). Glucose exposure rapidly re-created the acidic niches, indicating formation of diffusion barriers associated with microcolonies structure. Enamel demineralization(white spots),rougher surface, deeper lesion and more mineral loss appeared to be associated with the localization of these bacterial clusters at the biofilm-enamel interface. Similar 3D architecture was observed in plaque-biofilms formed in vivo in the presence of sucrose. The formation of complex 3D architectures creates spatially heterogeneous acidic microenvironments in close proximity of enamel surface, which might correlate with the localized pattern of the onset of carious lesions(white spot like) on teeth. | Jin Xiao Anderson T Hara Dongyeop Kim Domenick T Zero Hyun Koo Geelsu Hwang | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 2 | Topical fluoride for caries prevention显示文摘 | Robert J. Weyant Sharon L. Tracy Theresa (Tracy) Anselmo Eugenio D. Beltrán-Aguilar Kevin J. Donly William A. Frese Philippe P. Hujoel Timothy Iafolla William Kohn Jayanth Kumar Steven M. Levy Norman Tinanoff J. Timothy Wright Domenick Zero Krishna Aravam | 2013 | The Journal of the American Dental Association2013，，11： | 1 |
| 3 | 龋病预防和管理执行概要白皮书 疾病预防控制现状及关键措施概要 下显示文摘龋病预防合作(CPP)'龋病预防和管理白皮书'为牙医、其他口腔健康工作者和国家牙科协会(NDAs)提供了龋病预防和管理的知识方法.为患者龋病预防和管理带来最大利益。使用最好的方法来维持患者口腔健康是牙科专业人员的责任。尽管认识到龋病治疗的去腐和修复方法已经过时、成本高昂且无法确保患者获得最佳健康结果.但许多国家仍未采取预防龋病的方法。对于氟化物、封闭剂,其他控制糖摄入和预防保健方法,已有大量实证.已形成指南供专业人员掌握:优先预防,将修复方法作为最后手段。CPP白皮书中的13个关键问题,涵盖了以患者为中心和以证据为基础的龋病预防保健方法,并且提供了明确的行动措施要点。 | Nigel Pitts Domenick Zero 王晓燕(译) 岳林(审) | 2019 | 中国口腔医学继续教育杂志2019，22，6： | 0 |
| 4 | 龋病预防和管理执行概要白皮书疾病预防控制现状及关键措施概要·上显示文摘龋病预防合作(CPP)'龋病预防和管理白皮书'为牙医、其他口腔健康工作者和国家牙科协会(NDAs)提供了龋病预防和管理的知识方法,为患者龋病预防和管理带来最大利益。使用最好的方法来维持患者口腔健康是牙科专业人员的责任。尽管认识到龋病治疗的去腐和修复方法已经过时,成本高昂且无法确保患者获得最佳健康结果,但许多国家仍未采取预防龋病的方法。对于氟化物,封闭剂,其他控制糖摄入和预防保健方法,已有大量实证,已形成指南供专业人员掌握:优先预防,将修复方法作为最后手段。CPP白皮书中的13个关键问题,涵盖了以患者为中心和以证据为基础的龋病预防保健方法,并且提供了明确的行动措施要点。 | 王晓燕(译) 岳林(审) Nigel Pitts Domenick Zero | 2019 | 中国口腔医学继续教育杂志2019，22，3： | 0 |
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